Class 544/70 - Spiro

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which contain a spiro ring system.
No. of patents: 199
Last issue date: 10/11/2011

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Number	Title	Issue Date
8034928	Fluorescence assays with improved sensitivity Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more molecules of interest, such ...	10/11/2011
7619082	Process for the preparation of 3-spiro′cyclohexan-1,3′-′3H!indolin-2′-one! derivatives The invention relates to a process for the preparation of a compound of the formula (I) by reacting a compound of the formula (II) with a compound of the formula (III) characterized by dissolving the compounds of the formula (II) and formula (III) in a water-inmisci...	11/17/2009
7419969	HIV integrase inhibitors: cyclic pyrimidinone compounds The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates us...	09/02/2008
7332491	Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specificat...	02/19/2008
7309787	Kinase inhibitors The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ...	12/18/2007
7304081	Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases...	12/04/2007
7273859	HIV integrase inhibitors: cyclic pyrimidinone compounds The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates us...	09/25/2007
7262295	Indeno-fused photochromic naphthopyrans, naphthols and photochromic articles Described are photochromic materials of indeno [2′,3′:3,4]naphtho[1,2-b]pyran structure, characterized in that they have a nitrogen or sulfur containing substituent at the 11-position ring atom, are substantially free of spiro-substituents at the 13-position and...	08/28/2007
7250120	Benzo-, naphtho- and phenanthrochromene substituted by carbamated or ureated phenyls, preparation thereof and compositions and articles containing them Disclosed are novel benzo-, naphtho- and phenanthrochromenes substituted by carbamated or ureated phenyls having the following general formula (I): wherein R1 represents a group	07/31/2007
7214754	Polymerizable polyol (allyl carbonate) compositions A polymerizable composition is described, which composition comprises a major amount of a polyol(allyl carbonate) monomer, e.g., diethylene glycol bis(allyl carbonate) monomer, and a minor amount of a radically polymerizable second monomer represented by the general...	05/08/2007
7214676	Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are a...	05/08/2007
7147889	Organic photochromic compositions of improved kinetic performance Described are imbibition compositions that incorporate kinetic enhancing additive(s) into photochromic polymeric host material. Kinetic enhancing additives include organic polyol(s), epoxy-containing compound(s) or a mixture thereof that improves the performance of ...	12/12/2006
7144890	Spiro-pentacyclic compounds The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the treatment and/or prophyl...	12/05/2006
7144969	Impact resistant polyureaurethane and polyureaurethane prepolymer having low NCO/OH ratio The present invention relates to a polyureaurethane wherein the prepolymer comprising said polyureaurethane has a NCO to OH equivalent ratio of from 2.0 to less than 2.5. In an embodiment, the polyureaurethane prepolymer comprises a polyisocyanate and at least one O...	12/05/2006
7122662	Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e...	10/17/2006
7098290	Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups...	08/29/2006
7087698	Method of preparing an optical polymerizate The present invention is directed to a novel method of preparing a polymerizate, which includes the step of polymerizing a two-component composition, which includes: a first component containing at least one polycyanate reactant having at least two functional groups...	08/08/2006
7081457	Cyclothiocarbamate derivatives as progesterone receptor modulators Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have ...	07/25/2006
7008568	Photochromic naphthopyran compounds: compositions and articles containing those naphthopyran compounds A photochromic naphthopyran displays good color distribution when the naphthopyran has a central nucleus of the formula: wherein F is a 5-member, 6-member, or 7-member heterocyclic ring group ha...	03/07/2006
6995167	Arylkylamine spirofuropyridines useful in therapy A compound of formula I, wherein NRR1 is attached at the 5- or 6-position of the furopyridine ring; R is hydrogen, C1–C4 alkyl, or COR2; R1 is (CH2)	02/07/2006
6931713	Methods of making low loss, high frequency composite magnetic material A high frequency, low loss, power, laminated magnetic material includes alternating magnetic plates of low hysteresis loss material and electrically insulating films. The multi-layer structure allows for independently and simultaneously controlling and reducing hyst...	08/23/2005
6916807	Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as ...	07/12/2005
6900201	N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G...	05/31/2005
6872719	Phenylalanine enamide derivatives Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a —CH3, —(CH2)3CH3, —CH2CH2OH, —CH2CH2	03/29/2005
6756371	Phthalazinone derivatives as PDE4 inhibitors The compounds of formula (I) in which R1, R2, A, B and Ar have the meanings as given in the description are novel effective PDe4 inhibitors ...	06/29/2004
6727247	Substituted benzothiazole amide derivatives A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A2 receptor system comprising administering a compound of formula to a person in need of such treatment.	04/27/2004
6720420	Photochromic oxazine compounds and methods for their manufacture The present invention provides oxazine compounds having aromatic, heteroaromatic, or aliphatic substituents at the 2 position of the oxazine moiety. Additionally, a one pot method with excellent yields is provided for producing the compounds ...	04/13/2004
6706878	Spiroazabicyclic heterocyclic compounds A compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, a...	03/16/2004
6703502	Spiroazo bicyclic heterocyclic A compound of formula ##STR1## wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H2 or F2 ; A is N or C(R2); G is N or C(R3); D is N or C(R4); wit...	03/09/2004
6686466	Photochromic oxazine compounds and methods for their manufacture The present invention provides photochromic oxazine compounds and methods for their manufacture, which compounds are useful as photochromic compounds. The compounds of the invention have aromatic substituents on the 2 position of the oxazine moiety....	02/03/2004
6683709	Photochromic pyran compounds Photochromic pyran compounds and their use in synthetic resin objects of all types, especially for ophthalmic applications, particularly spiro compounds having a fluorene structure derived from naphthopyrans, which are known as spirofluorenopyrans. By int...	01/27/2004
6627634	Bicyclic heterocycles, pharmaceutical compositions containing them, their use, and processes for preparing them Bicyclic heterocycles of general formula ##STR1## wherein: Ra to Rd, A to C and X are as defined herein, the tautomers, the stereoisomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorg...	09/30/2003
6600039	PROCESS FOR THE PREPARATION OF N-(1,1-DIMETHYLETHYL)-4-[[5'-ETHOXY-4-CIS[2-(4-MORPHOLINO)ETHOXY]-2'-OXOSP IRO[CYCLOHEXAN-1,3'[H]INDOL]1'(2'-H)-YL]-SULFONYL]-3-METHOXYBENZAMIDE AND ITS SALTS The invention relates to a process for the preparation of a compound of formula (I) and the salts thereof by reacting the compound of formula (II) with the compound of formula (III), which comprises carrying out the reaction in dimethyl sulfoxide, at a te...	07/29/2003
6548679	Antitumor agents The present invention provides compounds of general formula I or II: ##STR1## wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceu...	04/15/2003
6511975	Spiropiperidine derivatives A compound of the formula (I) ##STR1## wherein R1 and R2 is a substituted or unsubstituted aryl group, or a substituted or unsubstituted heteroaryl group. A is CH2, CO or SO2. B is a single bond, alkylene or alk...	01/28/2003
6509334	Cyclocarbamate derivatives as progesterone receptor modulators This invention provides compounds of Formula (I): ##STR1## wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 ...	01/21/2003
6479489	Substituted spiroheterocyclic 1H-3-arylpyrrolidine-2,4-dione derivatives, methods of preparing them and their use as pest-control agents Pesticidal and herbicidal substituted spirocyclic 1-H-3-aryl-pyrrolidine-2,4-dione derivatives of the formula (I) ##STR1## is which A and B together with the carbon atom to which they are bonded represent an unsubstituted or substituted 5-6-membered cycle...	11/12/2002
6472398	Spiropiperidine derivatives as melanocortin receptor agonists Certain novel spiropiperidine derivatives of structural formula Ia wherein the substituents are as defined herein are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). T...	10/29/2002
6469076	Chromene compounds A photochromic compound which by itself develops a color tone of a neutral tint, exhibits a large fading rate and offers a good photochromic light resistance. A novel chromene compound has a basic structure as shown below in which a condensed ring formed ...	10/22/2002
6451843	Arylphenyl-substituted cyclic keto enols The present invention relates to novel arylphenyl-substituted cyclic ketoenols, their preparation and the use of such ketoenols as pesticides and/or herbicides. The novel arylphenyl-substituted cyclic ketoenols are of the formula (I) ##STR1## in whic...	09/17/2002

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Class 544/70 - Spiro