Class 544/58.6 - Ring nitrogen in the additional hetero ring, which is six-membered

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds having, in addition to the thiazine ring, a six-membered
No. of patents: 327
Last issue date: 10/28/2008

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Number	Title	Issue Date
7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R...	10/28/2008
7312212	Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ...	12/25/2007
7294629	Quinazoline derivatives A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a ...	11/13/2007
7196080	Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein ...	03/27/2007
7101874	Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is —S(═O)n—, —S(═NR8)—, or —S(═NR8)(═O)—; Z is �...	09/05/2006
7091200	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is...	08/15/2006
6992092	Anti-diabetic agents The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein R1, R2	01/31/2006
6964966	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydr...	11/15/2005
6921759	Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the prevention...	07/26/2005
6914058	Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotammers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceuti...	07/05/2005
6894046	IL-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 4; X is O, S, NR5	05/17/2005
6864368	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using the...	03/08/2005
6849732	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation The invention relates to compounds of the formula 1: wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and...	02/01/2005
6844347	Substituted 4-amino-2aryl-pyrimidines, their production and use and pharmaceutical preparations containing same The invention relates to compounds of formula I, in which R1, R2, R3 and R4 have the meanings given in the claims. Said compounds are valuable active ingredients for the trea...	01/18/2005
6770596	Fused tricyclic compounds, process for their preparation, and herbicidal compositions containing them Novel fused tricyclic compounds represented by formula (I) are described. Q, Y, —L—X—, A, A′, B, E, D, n and m are as defined in the disclosure. Also described are the processes for the manufacture of these compounds and agriculturally suitable compositions ...	08/03/2004
6743798	Substituted pyrazole derivatives condensed with six-membered heterocyclic rings The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation an...	06/01/2004
6683081	Triazolotriazinones and the use thereof The invention relates to novel triazolotriazinones of the general formula (I), to a method for their production and to the pharmaceutical use thereof. ##STR1##...	01/27/2004
6660732	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c...	12/09/2003
6656933	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c...	12/02/2003
6620810	4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents The invention provides a compound of formula I: ##STR1## wherein R1, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and in...	09/16/2003
6613772	Substituted 2-aryl-4-amino-chinazolines, method for the production and use thereof as medicaments Compounds of the formula I ##STR1## in which R1, R2, R3 and Ar have the meanings indicated in the claims, are suitable for the production of pharmaceuticals, for example for the prophylaxis and therapy of cardiovascular di...	09/02/2003
6608052	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut...	08/19/2003
6605608	Amino acid derivatives and drugs containing the same as the active ingredient The present invention relates to the compounds of the formula (I) and salts thereof (all the symbols are the same meanings as described in the specification). ##STR1## The compounds of the formula (I) possess inhibitory activity of N-type calcium cha...	08/12/2003
6583146	Thiazolopyrimidine compounds, its production and use Compounds represented by general formula (I): ##STR1## and salts thereof, exhibiting excellent adenosine A3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further substituted; and R1 is an optional...	06/24/2003
6579982	Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula ##STR1## wherein X, Y, Ar1, Z, R1, R2 and R3 are as defined in the specification, and to pharmaceutical compos...	06/17/2003
6559155	Pyrimidinone derivatives for the treatment of atherosclerosis Pyrimidones of formula (I) are inhibitors of the enzyme LpPLA2 and thereof use in treating inter alia atherosclerosis, ##STR1## in which: R1 is COOH or a salt thereof, COOR10, CONR11R.sup.12, CN or CH...	05/06/2003
6518423	Benzopiperidine derivatives Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: ##STR1## wherein the variables are as described in the specification. These compounds are useful as ...	02/11/2003
6509338	Pyrazolo[1,5-A]triazine corticotropin releasing factor antagonists The present invention describes novel pyrazolo[1,5-a]triazines of formula: ##STR1## wherein R3 is an alkyl, alkenyl, alkynyl, or cycloalkyl group, or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists....	01/21/2003
6509334	Cyclocarbamate derivatives as progesterone receptor modulators This invention provides compounds of Formula (I): ##STR1## wherein R1 and R2 may be single substituents or fused to form spirocyclic or hetero-spirocyclic rings; R3 is H, OH, NH2, C1 to C6 ...	01/21/2003
6500948	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof The invention relates to compounds of the formula 1: ##STR1## wherein: Z is O or S; V is a divalent radical which together with C* and N forms a ring having six ring atoms, where each of said ring atoms other than C* and N independently is unsubstituted o...	12/31/2002
6498158	Il-5 inhibiting 6-azauracil derivatives The present invention is concerned with the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 4; --A--B-- represents --(CH2...	12/24/2002
6479483	4-phenyl-pyridine derivatives Compounds of the present invention are 4-phenyl-pyridine derivatives with activity as NK-1 receptor antagonists....	11/12/2002
6458950	Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen,...	10/01/2002
6444809	Therapeutic heterocycles Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of as...	09/03/2002
6432947	N-heterocyclic derivatives as NOS inhibitors N-Heterocyclic derivatives of the formula (I): ##STR1## are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors o...	08/13/2002
6407103	Indeno [1,2-c] pyrazol-4-ones and their uses The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): ##STR1## that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and t...	06/18/2002
6380387	4-Pyrimidinyl-n-acyl-l phenylalanines Compounds of Formula I are disclosed, ##STR1## having activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells ...	04/30/2002
6358946	C-6 ring-substituted pyrido[1,2-a]benzimidazole derivatives useful in treating central nervous system disorders A C-6 ring-substituted pyrido[1,2-a]benzimidazole derivative of the formula: ##STR1## methods of preparation and pharmaceutical compositions containing a substituted pyrido[1,2-a]benzimidzole derivative as the active ingredient are disclosed. The sub...	03/19/2002
6358945	Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such c...	03/19/2002
6297258	Substituted 3-cyanoquinolines This invention provides compounds of formula I having the structure ##STR1## wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as...	10/02/2001

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Class 544/58.6 - Ring nitrogen in the additional hetero ring, which is six-membered