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| Number | Title | Issue Date |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7268124 | Geranylgeranyl pyrophosphate synthase inhibitors The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use. ... | 09/11/2007 |
| 7015217 | Cyclic sulfone derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) The present application describes novel cyclic sulfone derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α c... | 03/21/2006 |
| 6743798 | Substituted pyrazole derivatives condensed with six-membered heterocyclic rings The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which R1, R2, R3 and A are each as defined, and to processes for their preparation an... | 06/01/2004 |
| 6399782 | Benzimidazole inhibitors of fructose 1,6-bisphosphatase Novel benzimidazole compounds of the following structure and their use as fructose-1,6-bisphosphatase inhibitors is described ##STR1##... | 06/04/2002 |
| 6350749 | Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof The present invention is to provide a compound of the formula: ##STR1## wherein the ring A is an optionally substituted 5- to 6-membered aromatic heterocyclic ring, the ring B an optionally substituted 5- to 6-membered aromatic homocyclic ring or an optio... | 02/26/2002 |
| 6130231 | Integrin receptor antagonists This invention relates to novel fused heterocycles which are useful as antagonists of the v 댣 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compou... | 10/10/2000 |
| 6057304 | Quinoxaline-phosphonic acid derivatives The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R1, R4, R5, R6, R7 and R8 are as defined in the disclosure, as well as their production and use in medic... | 05/02/2000 |
| 6001832 | [1,2,4]triazolo[4,3-a]quinoxalinone derivatives, their preparation and use The present invention relates to [1,2,4]triazolo[4,3-a]quinoxalinone compounds of the formula ##STR1## wherein R1 is POX'X" or alkyl substituted with COX' or POX'X", and X' and X" independently are hydroxy or alkoxy, and R7 is ... | 12/14/1999 |
| 5962437 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus and herpes viruses, is disclosed. The method comprising administering to a subject in need of such treatment an infection-combating amount of a phospholipid or phospholipid ... | 10/05/1999 |
| 5955461 | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | 09/21/1999 |
| 5929236 | 2-substituted morpholine and thiomorpholine derivatives as GABA-B antagonists Disclosed are compounds of the formula I wherein: Y represents --CO2 H, --CO2 R6, --C(O)NHR7, --SO2 H, --SO3 H, --SO3 R6, --SO2 NHR7, --C(O)--N(OH)--R... | 07/27/1999 |
| 5914351 | Anti-viral aromatic hydrazones Compounds of the formula ##STR1## wherein Q is a hydrazone derivative; R1 is hydrogen, halogen, alkyl or alkoxy; R2 is hydrogen, halogen, alkyl, alkoxy, alkenoxy, alkynyloxy, halomethyl, trifluoromethoxy, alkylthio, nitro or cyano; a... | 06/22/1999 |
| 5580863 | Benzopyran derivatives and their use This invention relates to a compound represented by the formula: ##STR1## wherein B represents a hydrogen atom or a lower alkyl group; ring A represents a benzene ring which may have one or more substituents; .multidot..multidot..multidot..multidot..... | 12/03/1996 |
| 5556841 | Thiazine or thiomorpholine derivatives This invention relates to the compounds of the formula [I] which are useful for the treatment of cataracts, and the synthetic intermediates of the formula [II], ##STR1## wherein R1 is hydroxy which can be protected by a hydroxy protective ... | 09/17/1996 |
| 5543396 | Proline phosphonate derivatives Peptidyl derivatives of diesters of -aminoalkylphosphonic acids, particularly those with proline or related structures, their use in inhibiting serine proteases with chymotrypsin-like, trypsin-like, elastase-like, and dipeptidyl peptidase IV specif... | 08/06/1996 |
| 5536833 | Process for the preparation of intermediates useful in the preparation of pyranyl cyanoguanidine derivatives A process for preparing compounds of the formula ##STR1## where a, b, c, R1, R2, and R3 are as defined herein including the step of alkylating a phenol of formula ##STR2## with an acetylene of formula ##STR3... | 07/16/1996 |
| 5532226 | Trifluoromethybenzylphosphonates useful in treating osteoporosis Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.... | 07/02/1996 |
| 5457094 | Heterocyclic amidines useful for treating diseases associated with calcium metabolism Compounds of formula I ##STR1## wherein R, R1, R2 and q are as defined in the description, have valuable pharmacological properties and are especially effective as calcium metabolism regulators. They are prepared in a manner kno... | 10/10/1995 |
| 5413994 | Pharmaceutical compositions containing di-phosphonic acid amidines Compounds of formula I ##STR1## wherein R, R1, R2 and q are as defined in the description, have valuable pharmacological properties and are especially effective as calcium metabolism regulators. They are prepared in a manner kno... | 05/09/1995 |
| 5359064 | Salts of triazine derivatives with oxygenated acids of phosphorus This invention relates to salts of triazine derivatives with oxygenated as of phoshporus, having general formula (I): ##STR1## obtained by salification, with an acid containing phosphorus, of polycondensates of 2,4,6-triamino-1,3,5-triazine. The com... | 10/25/1994 |
| 5354753 | Methotrexate derivative Disclosed is a compound represented by the formula: ##STR1## wherein R1 : CH2, CH2 CH2, CH2 O, CH2 S, CH2 SO; R2 : hydrogen atom, a lower alkyl group having 1 to 4 ... | 10/11/1994 |
| 5308846 | Quinazolinones Substituted quinazolinones and pyridopyrimidines of structural formula 1 ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the renin-angiotensin system (RAS) such as hypertension, congestive heart failure, ocular... | 05/03/1994 |
| 5300687 | Trifluoromethylbenzylphosphonates useful in treating osteoporosis Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.... | 04/05/1994 |
| 5296598 | Derivatives of 2,4-diamino-1,3,5-triazinyl-6-phosphonic acid Derivatives of triazinylphosphonic acid having the general formula (I): ##STR1## obtained by means of the reaction of condensation of a cyanuric halide w an ester of phosphorous acid and subsequent reaction of substitution with a polyamine and an am... | 03/22/1994 |
| 5250521 | Substituted pyrazolopyrimidines as angiotensin II antagonists Novel substituted pyrazolopyrimidines of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##... | 10/05/1993 |
| 5202322 | Quinazolinone and pyridopyrimidine a-II antagonists Substituted quinazolinones and pyridopyrimidines of structural formula 1 ##STR1## are angiotensin II antagonists useful in the treatment of disorders related to the reninangiotensin system (RAS) such as hypertension, congestive heart failure, ocular ... | 04/13/1993 |
| 5187179 | Angiotensin II antagonists incorporating a substituted imidazo [1,2-b][1,2,4]triazole There are disclosed substituted imidazo[1,2-b][1,2,4]triazole derivatives of Formula I which are useful as angiotensin II antagonists. ##STR1##... | 02/16/1993 |
| 5162325 | Angiotensin II antagonists incorporating a substituted benzyl element Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##... | 11/10/1992 |
| 5120843 | Pharmaceutically active amines The aromatic amines (I), alkyl amines (II), bicyclic amines (III). ##STR1## cycloalkyl amines (IV), aromatic bicyclic amines (V), hydroquinone amines (VI), quinone amines (VII), amino-ethers (VIII) and bicyclic amino ethers (IX) are useful as pharmac... | 06/09/1992 |
| 5104985 | Labdane process Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 04/14/1992 |
| 5075293 | ((N-heterocyclyl)carbonyl)phosphoramidothioate ester insecticides O,S-Dialkyl ((nitrogen heterocyclyl)carbonyl)-phosphoramidothioates are prepared by the reaction of O,S-dialkyl phosphoroisocyanatidothioates with selected 5 and 6 membered nitrogen heterocycles, such as thiomorpholine and tetrahydroquinoline, and found t... | 12/24/1991 |
| 5071841 | Sulfur-containing heterocyclic compounds useful for the treatment of osteoporosis, and their production The present invention provides a sulfur-containing heterocyclic compound of the formula (I) ##STR1## wherein ring A is a benzene ring which may be substituted; R is a hydrogen atom or a hydrocarbon group which may be substituted; B is a carboxyl ... | 12/10/1991 |
| 5061813 | Substituted cyanoimino benzopyranes Novel compounds are disclosed having the formula ##STR1## and R1, R2, R3, R4, R5, R6 and R7 are as defined herein. These compounds are useful, for example, as cardiovascular... | 10/29/1991 |
| 5036152 | Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids Novel alkoxycarbonylalkylphospholipids, alkylaminocarbonylalkylphospholipids, processes for the preparation thereof, and methods for treating inflammation utilizing compounds or compositions thereof are disclosed.... | 07/30/1991 |
| 5030733 | Hydroxy-, alkoxy- and benzyloxy-substituted phospholipids Novel hydroxy-, alkoxy- and benzyloxy-substituted phospholipids, a process for the preparation thereof, and methods for treating pain, phospholipase, A2 mediated inflammation and similar conditions utilizing compounds or compositions thereof ar... | 07/09/1991 |
| 4992549 | Herbicidal compositions Aminotriazines of the formula ##STR1## wherein E is nitrogen, Z is oxygen or sulfur, R3 is hydrogen, C1 -C4 -alkyl, C3 -C4 -alkenyl or C1 -C4 -alkoxy, R4 is hydrogen, ... | 02/12/1991 |
| 4963538 | 5-oxygenated HMG-CoA reductase inhibitors Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) or (II): ##STR1## wherein position 5 of the polyhydronaphthyl ring is singly or doubly bonded to oxygen or incorporated in... | 10/16/1990 |
| 4952707 | Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes Chemiluminescent 1,2-dioxetane compounds are disclosed in which the molecule is stabilized at the 3-position on the dioxetane ring against decomposition prior to the molecule's coming in contact with a labile group-removing substance (e.g., an enzyme that... | 08/28/1990 |
| 4927835 | Acylphenol derivatives, useful as anti-inflammatory agents and pain suppressants Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R1 is cycloalkyl of 5 to 7 carbon atoms; aryl of 6 to 10 carbon atoms unsubstituted or substituted by straight or branched chain alkyl of 1 to 4... | 05/22/1990 |
