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Class 544/404 - N-hydrocarbyl piperazines


Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which a hydrocarbon substituent is bonded directly
No. of patents: 81
Last issue date: 01/08/2008


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NumberTitleIssue Date
7317101Antibacterial cephalosporins
A compound of formula wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent. ...
01/08/2008
7196033Advances in amination catalysis
Provided herein are catalysts useful in reductive amination, which include nickel, copper, zirconium and/or chromium, oxygen, and tin. The presence of the tin increases the selectivity of the catalyst in reductive aminations over the catalysts of the prior art. ...
03/27/2007
7022845Monomethylation of nitrogeneous heterocycles
A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×1...
04/04/2006
6943250Protected aminofunctionalized polymerization initiators and methods of making and using same
Anionic polymerization initiators useful in the preparation of polymers having a protected amine functional group. The amine functionality is part of a heterocyclic radical and includes a protecting group. ...
09/13/2005
6900313Chiral ionic liquids
The invention relates to chiral ionic liquids of the general formula [A]n+[Y]n−, whereby n=1 or 2, the anion [Y]n− is the anion of an organic or inorganic proton acid and the cation [A]+ ...
05/31/2005
6809202Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl gorup and 6-8 atoms in...
10/26/2004
6776911Methods for surface modification of silica for use in capillary zone electrophoresis and chromatography
The present invention refers to the use of novel molecules able to bind tenaciously to silica, borosilicate and silicate surfaces, and thus to modify their properties and characteristics. When applied to silica-based chromatography, it offers important advantages in...
08/17/2004
6734177Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said salts. ...
05/11/2004
6683181Pyrroloquinolones as antiviral agents
The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family....
01/27/2004
6603003Method for the preparation of piperazine and its derivatives
A novel method for the synthesis of piperazine and its derivatives of formula 1, ##STR1## wherein R is selected from hydrogen, or a lower alkyl group having 1 to 6 carbon atoms or a phenylalkyl group the alkyl of which has 1 to 4 carbon atoms; R...
08/05/2003
6441172Diketodiazacyclic compounds, diazacyclic compounds and combinatorial libraries thereof
The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring carbonyl group and 6...
08/27/2002
6384097Amine catalyst for producing rigid polyurethane foam
An amine catalyst for production of a polyurethane and a polyisocyanurate is provided which comprises a quaternary ammonium compound represented by General Formula (1): ##STR1## where R1 to R6 are independently a linear or branched s...
05/07/2002
6307102Amine catalyst for producing polyurethane and polyisocyanurate
An amine catalyst-for production of a polyurethane and a polyisocyanurate is provided which comprises a quaternary ammonium compound represented by General Formula (1): ##STR1## where R1 to R6 are independently a linear or branched s...
10/23/2001
6191277Hydroxypropylamide peptidomimetics as inhibitors of aspartyl proteases
Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathsepsin D. The compounds are useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred compounds ...
02/20/2001
5977359Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present
The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH
11/02/1999
5895816Preparation of alkylamines
In a process for preparing alkylamines by reacting amines and aliphatic aldehydes in the presence of free hydrogen on a fixed bed catalyst in a reactor in which amines and aldehydes are mixed in the catalyst bed after being fed in in separate streams, onl...
04/20/1999
58861757-(substituted)-8-(substituted)-9-(substitued amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents....
03/23/1999
5780470Melatonergic indanyl piperazines
Certain indanyl piperazines are useful as melatonergic agents and can treat various CNS disorders. They are use useful in treating sleep disorders and other conditions related to circadian rhythms....
07/14/1998
5626724Recovery of N-ethylpiperazine by distillation
In a process for the recovery of N-ethylpiperazine by distillation from mixtures with N,N'-diethylpiperazine, piperazine, ethanol, water and accompanying substances, water is added in a manner such that, at the location of the addition of the water, the p...
05/06/1997
5495032Process for producing 7-(substituted)-8-(substituted-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein, R, R3, R4, X and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted w...
02/27/1996
5495031Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with ...
02/27/1996
54950187-(substituted-9-(substituted amino)-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formulas ##STR1## which are useful as intermediates for the preparation of 6-demethyl-6-deotetracycline antibiotic agents....
02/27/1996
5463130Preparation of peralkylated amines
A process for the preparation of peralkylated amines of the general formula I ##STR1## in which R1, R2 denote C1 -C200 alkyl, C3 -C8 cycloalkyl, C4 -C20 alkylcycl...
10/31/1995
54202727-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formula: ##STR1## wherein R, R3, R4, X and W are defined in the specification. These compounds are useful as antibiotic agents....
05/30/1995
5414087Preparation of N-alkylpiperazines
Disclosed is a one-step method for preparing N-alkylpiperazines which eliminates the initial preparation and isolation of piperazine which comprises reacting a carbonyl compound and an amine in the presence of hydrogen over a metallic hydrogenation-dehydr...
05/09/1995
5347003Methods for regenerating a sulfur scavenging compound from a product of a sulfur scavenging reaction
Methods are provided whereby an N-C-N compound is regenerated from a product of a sulfur scavenging reaction, in which said N-C-N compound removes a sulfur atom from a sulfur compound, to form the original N-C-N compound. The N-C-N compound is represented...
09/13/1994
53289027-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
The invention provides compounds of the formula: ##STR1## wherein R, R3, R4 and W are defined in the specification. These compounds are useful as antibiotic agents....
07/12/1994
5296633HMTA preparation of methylated tertiary amines
The methylated tertiary amines are selectively prepared by reacting a primary or secondary amine, or a nitrile or aminonitrile, including an aminoalcohol, etheramine, a polyamine or fatty polyamine or amidoamine, or amidopolyamine or dinitrile, with hexam...
03/22/1994
5245032Catalytic processes for the preparation of N,N,N-trisubstituted nitrogen-containing compounds
A process for preparing N,N,N-trisubstituted nitrogen-containing compounds which comprises contacting a carboxylated N,N,N-trisubstituted nitrogen-containing compound with a mixed metal oxide catalyst under conditions effective to produce the N,N,N-trisub...
09/14/1993
5210193Piperazine derivatives
7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infec...
05/11/1993
5166433Catalyst and the amination of alcohols under hydrogenating conditions
Catalysts whose active material contains, in addition to from 20 to 85% by weight, calculated as ZrO2, of oxygen-containing zirconium compounds, from 1 to 30% by weight, calculated as CuO, of oxygen-containing compounds of copper and from 1 to ...
11/24/1992
5164497Decarboxylation processes using mixed metal oxide catalysts
A decarboxylation process which comprises contacting a carboxylated compound with a metal oxide catalyst under conditions effective to decarboxylate the carboxylated compound....
11/17/1992
49803771-(aminophenyl)-2-aminopropanone derivatives
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH2, Y is H or a halogen atom, Z is H or a halogen atom, R1 is C1 -C
12/25/1990
4911793Distillative isolation of N-ethylpiperazine in the presence of water
N-Ethylpiperazine is isolated by distillation from a mixture consisting per 100 kg of a=from 30 to 90 kg of N-ethylpiperazine b=from 7 to 40 kg of N,N'-diethylpiperazine c=from 3 to 20 kg of piperazine d=from 0 to 30 kg of ethanol e=from 0 to 40 kg of water and f=f...
03/27/1990
4876352Pressurized fluorination of hydroxy alkyl groups
There is disclosed a high yielding process for converting a hydroxy alkyl oxazolidine compound to the corresponding fluoro derivative by reacting the hydroxy compound with ଱, ଱-difluoroalkylamine under pressure....
10/24/1989
4845218Preparation of n-methylpiperazine
A process for the preparation of N-methylpiperazine from diethanolamine and methylamine, wherein the reaction is carried out at elevated temperature and superatmospheric pressure in the presence of hydrogen over a metal-containing catalyst....
07/04/1989
4774336Process for preparing N-substituted piperazines from ethylene glycol and amines
N,N'-dialkylpiperazines are prepared by contacting ethylene glycol and a primary amine in the presence of a homogeneous ruthenium-phosphine catalyst. For example, ethylene glycol and aniline are reacted in the presence of ruthenium trichloride and triphen...
09/27/1988
4757144Preparing tertiary amine from formaldehyde and primary and/or secondary amine
A tertiary amine is effectively prepared by reacting a primary or secondary amine with formaldehyde in the presence of a palladium or platinum catalyst at a hydrogen pressure of 3 to 50 kg/cm2 (gauge pressure) at a temperature of 80° to 180° C., by cont...
07/12/1988
4757143Catalytic method for the manufacture of triethylenediamine
Cyclic and acyclic hydroxyethyl ethylenepolyamines are converted to triethylenediamine when using a catalyst composed of zirconia or titania to which from about 0.5 to about 7 wt. % of phosphorous has been thermally chemically bonded in the form of phosph...
07/12/1988
4754036Conjoint production of C-methyl triethylene diamine and allyl piperazine
N-(hydroxypropyl) piperazine and/or N,N'-(dihydroxypropyl) piperazine can conjointly be converted to C-methyl-triethylenediamine and allyl piperazine with excellent conjoint yield and selectivity when using a catalyst composed of titania to which from abo...
06/28/1988
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