Class 544/381 - Piperazine ring bonded directly to the polycyclo-carbocyclic ring system

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the polycyclo-carbocyclic ring system
No. of patents: 32
Last issue date: 05/08/2007

Number	Title	Issue Date
7214673	Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independen...	05/08/2007
7186726	Preferentially substituted calcium channel blockers Certain piperazine substituted compounds are described which are useful in altering calcium channel activity. ...	03/06/2007
7125535	Method of preparing anhydrous manganese chloride An efficient process for forming anhydrous metal halides includes the reaction of a metal powder with a hydrogen halide under anhydrous conditions. In one example, manganese powder is reacted with hydrogen chloride under anhydrous reaction conditions. ...	10/24/2006
7087599	Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v...	08/08/2006
6951862	Calcium channel blockers comprising two benzhydril moieties Certain piperazine substituted compounds are described which are useful in altering calcium channel activity. ...	10/04/2005
6881841	Dibenzosuberanyl piperazine derivatives and drug-resistance overcoming agents containing the derivatives Dibenzosuberanyl piperazine derivatives represented by the following formula (I): wherein R represents an aliphatic hydrocarbon group, which may contain one or more heteroatom-containing substituent groups and may preferably cont...	04/19/2005
6624304	Process for preparing a 10,11-methanodibenzosuberane derivative This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]- 2-hydroxypropoxy}quinoline....	09/23/2003
6570016	Process for preparing a 10,11-methanodibenzosuberane derivative This invention provides a process to prepare (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]- 2-hydroxypropoxy}quinoline....	05/27/2003
6521755	Process for preparing 10,11-methanobenzosuberane derivatives This invention provides a process to prepare 10,11-(optionally substituted)methanodibenzosuberane derivatives. The invention also provides an intermediate in this process....	02/18/2003
6274583	Alpha 1a adrenergic receptor antagonists This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha-1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These ...	08/14/2001
6214827	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In ...	04/10/2001
6054458	Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to me...	04/25/2000
6025359	Drug resistance and multidrug resistance modulators Drug and multidrug resistant modulators of the formula: ##STR1## where R1 and R2 are independently hydrogen or halo; A is --CH2 --CH2 --, --CH2 --CHR4 --CH2 --, or --CH...	02/15/2000
5834459	Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or heterocyclic rings; X1 is selected from CH	11/10/1998
5776939	Drug resistance and multidrug resistance modulators Drug and multidrug resistant modulators of Formula (C): ##STR1## where Z is selected from the group consisting of --S--, --S(O)w --, and --CH2 --, where w is 1 or 2; and pharmaceutically acceptable salts or solvates thereof are ...	07/07/1998
5654304	10,11-methanodibenzosuberane derivatives 10,11-Methanodibenzosuberane derivatives, i.e., the compounds of Formula I: ##STR1## wherein: A is --CH2 --CH2 --, --CH2 --CHRa --CH2 --, or --CH2 --CHRa --CHRb --CH	08/05/1997
5488119	Polymerisable photochromic naphthacenediones, polymers of these monomers, process for their preparation and the use thereof Compounds of formulae I and II ##STR1## wherein D is H or --OR wherein R is phenyl and R1 to R4 are H or a substituent such as phenylthio, and one of the substituents R1, R2, R3 and R4...	01/30/1996
5215992	Ethanobicyclic amine derivatives for CNS disorders Certain ethanobicyclic amine compounds are described for treatment of CNS disorders such as psychotic disorders, convulsions, dystonia and cerebral ischemia. Compounds of particular interest are of the formula ##STR1## wherein each of R1, ...	06/01/1993
5189065	Use of derivatives of 9,10-dihydrophenanthrene for the preparation of an anti-tumor medicament The use of products of formula (I) is described, wherein X and Y represent hydrogen, hydroxy or alkoxy; and R1 and R2 represent H, alkyl, alkenyl or alkynyl, arylalkyl, acyl or R1 and R2 together with nitrogen f...	02/23/1993
4762927	Indene compounds The invention provides an indene compound represented by the following general formula (I): ##STR1## wherein R1 means a lower alkyl group, R2 and R3 denote a lower alkyl group individually or an alkylenedioxy group in...	08/09/1988
4610986	Aminonaphthacene derivatives and their production A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: ##STR1## wherein R1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R2 is a hydrogen atom or a hydroxyl group, R3...	09/09/1986
4564698	Biologically-active tricyclic amines The present invention relates to new tricyclic compounds of the formula: ##STR1## having valuable CNS and cardiovascular properties....	01/14/1986
4505913	Substituted anthranilamides and pharmaceutical preparations containing these compounds Substituted anthranilamides of the formula ##STR1## in which R1 is hydrogen or an aliphatic, cycloaliphatic or cycloaliphatic-aliphatic hydrocarbon radical, R2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, ...	03/19/1985
4447610	10-Substituted 5-cyanomethylene-dibenzo[A,B]-cycloheptenes, their preparations, and therapeutic agents containing these compounds 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds an...	05/08/1984
4376773	10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo-[a,d]-cycloheptenes, their preparation, and therapeutic agents containing these compounds 10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo[a,d]-cycloheptenes, their pharmaceutically tolerated addition salts with acids, processes for their preparation, and their use as drugs, especially as sedatives, hypnotics or tranquilizers....	03/15/1983
4156694	Benzobicyclononene derivatives The present invention relates to novel benzo(b) bicyclo[3.3.1]nones of the general formula I: ##STR1## and a salt or nitrogen oxide thereof, in which R1 and R2 stand for hydrogen, alkyl of 1-6 carbon atoms, alkenyl of 1-6 carbon...	05/29/1979
4113726	Perhydrofluorenetetrol and perhydrophenanthrenetetrol derivatives Compounds are provided having the structure ##STR1## wherein n is 1 or 2, n1 is 0, 1 or 2 and n2 is 0, 1, 2 or 3, R1, R2, R3 and R4 may be the same or different and can be hydrogen, lo...	09/12/1978
4107206	Benzo-bicyclononene- derivatives The present invention relates to novel biologically active tricyclic compounds of the general formula: ##STR1## and salts thereof, IN WHICH R1 and R2 stand for hydroge, alkyl or alkenyl, an optionally substituted aralkyl group o...	08/15/1978
4008277	Benzo-bicyclononene derivatives The present invention relates to novel biologically active tricyclic compounds of the general formula: ##STR1## and salts thereof, in which R1 and R2 stand for hydrogen, alkyl or alkenyl, an optionally substituted aralkyl group ...	02/15/1977
3984419	Perhydrofluorenetetrol and perhydro-phenanthrenetetrol derivatives Compounds are provided having the structure ##SPC1## Wherein n is 1 or 2, n1 is 0, 1 or 2 and n2 is 0, 1, 2 or 3, R1, R2, R3 and R4 may be the same or different and can be hydrogen, lower a...	10/05/1976
3937701	1-(10-Cyano/halo-5H-dibenzo[a,d]cyclohepte n-5-yl)-4-[(pyridylmethylene)amino]piperazines Preparation and the anticonvulsant utility of 1-(10-cyano/halo-5H-dibenzo[a,d]cyclohepten-5-yl)-4-[(pyridylmethylene)ami no]piperazines are disclosed....	02/10/1976

PatentStorm

Bizarre Patents

PatentStorm News

Class 544/381 - Piperazine ring bonded directly to the polycyclo-carbocyclic ring system