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| Number | Title | Issue Date |
| 8114997 | N-acylcytosine nucleosides for treatment of viral infections The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration... | 02/14/2012 |
| 7994318 | Coumarin derivatives useful as TNFα inhibitors Novel compounds composition capable of inhibiting TNFα and having antiimmunionflammatory and autoimmune properties useful in a pharmaceutical composition, such as for a drug containing this as an active ingredient; and a therapeutic method with the use of these nov... | 08/09/2011 |
| 7812159 | Processes for preparing aromatic ethers The present invention relates to processes for preparing aromatic ether compounds that are modulators of glucose metabolism and therefore useful in the treatment of metabolic disorders such as diabetes and obesity. ... | 10/12/2010 |
| 7414011 | Phenylsulfonyl ureas, process for their preparation and their use as herbicides and plant growth regulators Disclosed are compounds of the formula (I) or salts thereof in which R1, R2, R3, R4, I, R5, Q, R4, W, X, Y, V and Z, are as defined in the specification, whi... | 08/19/2008 |
| 7393845 | Heteroaryl derivates, their preparation and use A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disord... | 07/01/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7288544 | Pyrimidine compounds useful as N-type calcium channel antagonists Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains ... | 10/30/2007 |
| 7244692 | Substituted benzoylcyclohexane diones for use as herbicides The invention relates to novel substituted benzoylcyclohexanediones of formula (I) in which A1 represents a single bond or represents alkanediyl (alkylene) hav... | 07/17/2007 |
| 7238697 | Pyridylpyrimidines for use as pesticides The present invention relates to novel pyridylpyrimidines of the formula in which R1, R2, X, n, Y, Z and R have the meanings given in the disclosure, to a plurality of processes for preparin... | 07/03/2007 |
| 7232905 | Substituted dihydropyrimidinone preparation using polyaniline salt catalyst The present invention provides a process for the preparation of substituted dihydropyrimidinones using polyaniline salts as reusable catalysts, which comprises reacting an aldehyde, a β-keto ester and urea/thiourea in the presence of a polyaniline salt catalyst and... | 06/19/2007 |
| 7230104 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered h... | 06/12/2007 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
| 7192572 | Compound delivery systems A composition comprising (a) from 0.005% to 0.5% by weight of a cooling compound; (b) from 0.1% to 10% by weight of an emulsifiable substance; (c) from 0.15% to 15% by weight of a surfactant; ... | 03/20/2007 |
| 7179812 | Diazine derivatives The present invention provides compounds of formula (I): their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, ph... | 02/20/2007 |
| 7157580 | Aminopyrimidine and aminopyridine anti-inflammation agents Aminopyrimidine and aminopyridine (I) compounds, compositions and methods useful in the treatment of inflammatory, metabolic or malignant conditions, are provided herein ... | 01/02/2007 |
| 7148349 | Cyclic phosphate diesters of 1,3-propane-1-aryl diols and their use in preparing prodrugs Compounds of Formula I, their preparation and synthetic intermediates, and their use in the synthesis of prodrugs: wherein: V and L are trans relative to one another; ... | 12/12/2006 |
| 7119097 | Carboxylic acid derivatives, their preparation and their use A compound of the formula pharmaceutically acceptable salts and enantiomers thereof and pharmaceutical compositions containing this compound, its pharmaceutically acceptable salts and enantiomers are claimed. | 10/10/2006 |
| 7109205 | Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R–R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ... | 09/19/2006 |
| 7109334 | Stereoselective methods for the preparation of nucleosides A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, c... | 09/19/2006 |
| 7109148 | Stem/leaf desiccant A stem/leaf desiccant for crop plants which comprises as an active ingredient, a compound of formula (I): wherein X represent CH or nitrogen; Z represents halogen; A represents oxygen, sulfur, or NH; R1 | 09/19/2006 |
| 7105527 | N-acylcytosine nucleosides for treatment of viral infections The present invention is directed to a method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the administration... | 09/12/2006 |
| 7105520 | Phenylalanine derivatives Phenylalanine derivatives of the following formulae and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin ... | 09/12/2006 |
| RE39265 | Heteroarylpiperidines, and their use as antipsychotics and analgetics Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compound... | 09/05/2006 |
| 7026327 | Pyrimidine derivatives useful as selective COX-2 inhibitors The invention provides the compounds of formula (I) in which: R1 is selected from the group consisting of H, C1-6alkyl, C1-2alkyl substituted by one to five fluorine atoms,... | 04/11/2006 |
| 7022701 | Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ... | 04/04/2006 |
| 7019002 | Pyridopyrimidinones derivatives as telomerase inhibitors The invention provides pyrido[2,3-d]pyrimidin-7(8H)-one telomerase inhibitors of the formula where R1, R2 are as defined herein. The invention also provides methods for preparing the compounds of formula I, methods of u... | 03/28/2006 |
| 6943252 | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines Pyrimidines of formula I in which R1 represents hydrogen or alkyl, haloalkyl, alkenyl, alkynyl, alkadienyl, alkoxy, cycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5-... | 09/13/2005 |
| 6939965 | Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono-isopropoxide Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include reacting a 5-O-protected-oxymethyl-1,3-oxathiolane with a silylated nucleoside in the presence of (Cl)3Ti(isopropoxide). Using the processes described herein, the compo... | 09/06/2005 |
| 6933301 | 1,2,3,6-tetrahydropyrimidine-2-one compositions, articles and therapeutic methods for upper airway breathing disorders A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount. The cold receptor agonist may be represented by the general formula 1-[R1-phen... | 08/23/2005 |
| 6927193 | Aryl ether derivatives and processes for their preparation and herbicidal and desiccant compositions containing them Substituted aryl ether derived compounds represented by the general structure (I) are described. X and Y are independent of each other and are represented by hydrogen, halogen, cyano, nitro, (C1-4)alkyl, (C1-4)haloalkyl, or (C1-4)hal... | 08/09/2005 |
| 6924251 | Substituted benzoylcyclohexandiones The invention relates to novel substituted benzoylcyclohexanediones of the general formula (I), in which m, n, A, R1, R2, R3, R4 and Z are each as defined in the... | 08/02/2005 |
| 6921767 | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of select... | 07/26/2005 |
| 6919347 | Bradykinin B1 receptor antagonists Bradykinin B1-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflamma... | 07/19/2005 |
| 6919348 | Therapeutic 1,2,3,6-tetrahydropyrimidine-2-one compositions and methods therewith A therapeutic composition is provided that comprises a 1-R1-phenyl, 4-R2-phenyl substituted 1,2,3,6-tetrahydropyrimidine-2-one cold receptor agonist in a therapeutically effective amount and preferably further comprises one or more pharmaceutically active drugs such... | 07/19/2005 |
| 6855716 | Dihydropyrimidine compounds and compositions containing the same Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels. ... | 02/15/2005 |
| 6838415 | Substituted benzoylisoxazoles and the use thereof as herbicides The invention relates to novel substituted benzoylisoxazoles of the general formula (I), in which n represents the number 0, 1, 2 or 3, A represents a single bond or ... | 01/04/2005 |
| 6835216 | Chain-breaking antioxidants Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than t... | 12/28/2004 |
| 6831081 | 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family. ... | 12/14/2004 |
| 6818648 | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof The present invention provides novel compounds, and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsey, irritable bowl sy... | 11/16/2004 |
| 6787544 | Nitrogen-containing heterocyclic carboxamide derivatives or salts thereof and antiviral agents comprising the same Nitrogen-containing heterocyclic carboxamide derivatives represented by the following general formula: wherein ring A is a substituted or unsubstituted pyrazine, pyrimidine, pyridazine or triazine ring; R1 is ... | 09/07/2004 |
