Class 544/315 - At 2-position

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium,
No. of patents: 368
Last issue date: 08/30/2011

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Number	Title	Issue Date
8008488	Pyrimidin-2-one compounds and their use as dopamine Dreceptor ligands The invention relates to pyrimidin 2-one compounds of general formula (I), in addition to the derivatives and tautomers of (I) and the physiologically acceptable salts of said compounds. In said formula, A represents linear or branched C3-C6 al...	08/30/2011
7923556	Phenyl-substituted pyrimidine compounds useful as kinase inhibitors Compounds having the formula (I), and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein: two of X1, X2, and X3	04/12/2011
7863445	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R-R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ...	01/04/2011
7816528	Preparation of aminopyrimidine compounds A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; ...	10/19/2010
7745623	Cyclic amide derivative, and its production and use The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I): wherein R1 represents an optionally substituted cyclic hydrocarbon group...	06/29/2010
7709637	5-phenylpyrimidines, their preparation, intermediates for their preparation, and their use for controlling harmful fungi 5-Phenylpyrimidines of the formula I, in which the substituents have the following meanings: R1 is a five- to ten-membered saturated, partially unsaturated or aromatic mono- or bicyclic heterocycle c...	05/04/2010
7351700	Aminomethylpyrimidines as allosteric enhancers of the GABA receptors The present invention relates to compounds of formula wherein X is —S— or —NH—; R3/R4 together with the N-atom to which they are attached for...	04/01/2008
7317014	Bio-active pyrimidine molecules The present invention relates to novel derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutical...	01/08/2008
7312209	Acridone inhibitors of IMPDH enzyme Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O)2—; or W...	12/25/2007
7312329	Process for the preparation of pyrimidine derivatives An improved process for the preparation of pyrimidine derivatives is provided comprising reacting a Wittig reagent of the general formula wherein R is an alkyl of from 1 to 10 carbon atoms, aryl or arylalkyl, R	12/25/2007
7304156	Preparation of aminopyrimidine compounds A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; ...	12/04/2007
7301021	Substituted imidazole compounds Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ...	11/27/2007
7297694	Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ...	11/20/2007
7288544	Pyrimidine compounds useful as N-type calcium channel antagonists Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains ...	10/30/2007
7265115	Diazabicyclic CNS active agents Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals. ...	09/04/2007
7259162	Benzazole derivatives and their use as JNK modulators The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, t...	08/21/2007
7244692	Substituted benzoylcyclohexane diones for use as herbicides The invention relates to novel substituted benzoylcyclohexanediones of formula (I) in which A1 represents a single bond or represents alkanediyl (alkylene) hav...	07/17/2007
7238697	Pyridylpyrimidines for use as pesticides The present invention relates to novel pyridylpyrimidines of the formula in which R1, R2, X, n, Y, Z and R have the meanings given in the disclosure, to a plurality of processes for preparin...	07/03/2007
7232905	Substituted dihydropyrimidinone preparation using polyaniline salt catalyst The present invention provides a process for the preparation of substituted dihydropyrimidinones using polyaniline salts as reusable catalysts, which comprises reacting an aldehyde, a β-keto ester and urea/thiourea in the presence of a polyaniline salt catalyst and...	06/19/2007
7208510	Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ...	04/24/2007
7192572	Compound delivery systems A composition comprising (a) from 0.005% to 0.5% by weight of a cooling compound; (b) from 0.1% to 10% by weight of an emulsifiable substance; (c) from 0.15% to 15% by weight of a surfactant; ...	03/20/2007
7179806	Δ1-pyrrolines used as pesticides The invention relates to novel Δ1-pyrrolines of the formula (I) in which R1, R2, R3, m, and Q have the meanings given in the disclosure, to a plurality of processes fo...	02/20/2007
7166597	Fused pyrazole derivatives being protein kinase inhibitors Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors	01/23/2007
7144888	Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an...	12/05/2006
7141569	Antiviral pyrazolopyridine compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ...	11/28/2006
7119097	Carboxylic acid derivatives, their preparation and their use A compound of the formula pharmaceutically acceptable salts and enantiomers thereof and pharmaceutical compositions containing this compound, its pharmaceutically acceptable salts and enantiomers are claimed.	10/10/2006
7115593	Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio...	10/03/2006
7109205	Carboxylic acid derivatives, their preparation and use Carboxylic acid derivatives where R–R6, X, Y and Z have the meanings stated in the description, and the preparation thereof, are described. The novel compounds are suitable for controlling diseases. ...	09/19/2006
7109148	Stem/leaf desiccant A stem/leaf desiccant for crop plants which comprises as an active ingredient, a compound of formula (I): wherein X represent CH or nitrogen; Z represents halogen; A represents oxygen, sulfur, or NH; R1	09/19/2006
7098331	Arylvinylazacycloalkane compounds and methods of preparation and use thereof Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or trea...	08/29/2006
7091202	4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators The invention encompasses compounds of Formula I, which are blockers of KCNQ channels. Blockers of KCNQ channels are known to enchance cognition in laboratory animals. The invention includes, salts, solvates, compositions, and methods of use ...	08/15/2006
7067664	Corticotropin releasing factor antagonists Corticotropin-releasing factor (CRF) antagonists having the formulae wherein the dashed lines, A, B, Y, Z, G, R3, R4, R5, R6, R16 an...	06/27/2006
7064136	Compounds A compound having the general formula and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds. ...	06/20/2006
7060707	Isoquinoline derivatives Isoquinoline derivatives of the general formula (I) in which X, Y, Z, R1, R2 and n are as defined in Patent Claim (1), and physiologically acceptable salts or solvates thereof, are integrin inhibitors and can be employed for combating th...	06/13/2006
7026478	Iron catalyzed cross coupling reactions of aromatic compounds A process for the production of compounds Ar—R1 by means of a cross-coupling reaction of an organometallic reagent R1-M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts ...	04/11/2006
7026327	Pyrimidine derivatives useful as selective COX-2 inhibitors The invention provides the compounds of formula (I) in which: R1 is selected from the group consisting of H, C1-6alkyl, C1-2alkyl substituted by one to five fluorine atoms,...	04/11/2006
6936616	Pyrimidine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are pyrimidine derivatives of the formula or a pharmaceutically acceptable salt thereof, wherein: R2 is hydrogen, halo, hydroxy...	08/30/2005
6919346	Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, ...	07/19/2005
6906076	Compounds and methods of use to treat infectious diseases The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into ...	06/14/2005
6878717	HIV replication inhibiting pyrimidines This invention concerns the use of compounds of formula: the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=-a2	04/12/2005

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Class 544/315 - At 2-position