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| Number | Title | Issue Date |
| 7479560 | Creatine pyroglutamic acid salts and methods for their production and use in individuals The present invention relates to a method of production and the use of a compositional ingredient. Specifically, the present invention relates to hydrosoluble stable organic salts of creatine and pyroglutamic acid. The compositional ingredient may be useful for the ... | 01/20/2009 |
| 7407914 | Herbicide composition The present invention relates to an herbicide composition comprising, as active ingredients, a uracil compound represented by the following formula (I): wherein Z represents halogen or cyano; A repr... | 08/05/2008 |
| 7348334 | Monocyclic derivatives of aryl alkanoic acids and their use in medicine: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel hypolipidemic, antihyperglycemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates an... | 03/25/2008 |
| 7329763 | Creatine pyroglutamic acid salts and methods for their production and use in individuals The present invention relates to a method of production and the use of a compositional ingredient. Specifically, the present invention relates to hydrosoluble stable organic salts of creatine and pyroglutamic acid. The compositional ingredient may be useful for the ... | 02/12/2008 |
| 7288546 | Method and compound for inhibition of cell death This invention relates to a chemical compound that inhibits the apoptotic activity of the protease Omi/HtrA2 and homologous proteins. This protease Omi/HtrA2 is present in all mammalian cells so that inhibition of apoptosis in this fashion results enhanced cellular ... | 10/30/2007 |
| 7230100 | Stereoselective method for the preparation of nucleosides A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, c... | 06/12/2007 |
| 7205260 | Herbicide composition The present invention relates to an herbicide composition comprising, as active ingredients, a uracil compound represented by the following formula (I): wherein Z represents halogen or cyano; A represents oxygen,... | 04/17/2007 |
| 7179815 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R... | 02/20/2007 |
| 7169790 | 5-substituted 2-aryl-4-pyrimidinones Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating diso... | 01/30/2007 |
| 7138404 | 4-aminopyrimidine derivatives This invention is 4-aminopyrimidine derivatives of the formula wherein R1, R2, R3 and R4 are as defined in the specification or a pharmaceutically acceptable salt there... | 11/21/2006 |
| 7115544 | Plant growth regulators for cotton hervest A plant growth regulator for cotton harvest, which contains as an active ingredient, a compound of formula (I): wherein X is CH or nitrogen; Z is halogen; A is oxygen, sulfur, or NH; R1 is hydroxyl, C | 10/03/2006 |
| 7109334 | Stereoselective methods for the preparation of nucleosides A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, c... | 09/19/2006 |
| 7026477 | Process for preparing substituted phenylsulfonylureas from sulfonyl halides The invention relates to a preparation process for a compound (I) or a salt thereof, in which Q, X*, Y, Z, R, R1, R2 and R3 are as defined in claim 1, | 04/11/2006 |
| 6987114 | Antiviral pyrimidinedione derivatives and process for the preparation thereof The present invention relates to pyrimidinedione derivatives of following formula (I) which are useful as antiviral agents, especially as agents for treatment of AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical ... | 01/17/2006 |
| 6960568 | Nucleosides and related processes, pharmaceutical compositions and methods The invention provides novel nucleosides and related processes, pharmaceutical compositions, and methods. The novel nucleosides are useful in a wide variety of antiviral, antineoplastic, and antibacterial applications. Preferred embodiments of the instant invention ... | 11/01/2005 |
| 6958345 | 2-hydroxymethylcyclopropylidene methylpurines and -pyrimidines as antiviral agents Compounds which are active against viruses have the following Formulas: wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6-diamino... | 10/25/2005 |
| 6943173 | 5-substituted 2-aryl-4-pyrimidinones Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating diso... | 09/13/2005 |
| 6939965 | Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono-isopropoxide Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include reacting a 5-O-protected-oxymethyl-1,3-oxathiolane with a silylated nucleoside in the presence of (Cl)3Ti(isopropoxide). Using the processes described herein, the compo... | 09/06/2005 |
| 6936602 | Benzazepine derivatives, process for the preparation of the same and uses thereof Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which... | 08/30/2005 |
| 6930112 | Anti-epileptogenic agents Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and epileptogenesis. Methods for preparing the compounds of the invention are also d... | 08/16/2005 |
| 6924271 | 3-β-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof The invention is directed to 3-β-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compou... | 08/02/2005 |
| 6872728 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R... | 03/29/2005 |
| 6838562 | Process for preparing a creatine heterocyclic acid salt and method of use This invention relates to a process for the synthesis and method of use of an effective amount of a creatine heterocyclic acid salt for the regulation athletic function in humans. ... | 01/04/2005 |
| 6787539 | 2,4,5,-trisubstituted pyrimidine derivatives The invention relates to compounds of the formula wherein R1 is lower alkyl, lower alkoxy, pyridinyl, pyrimidinyl, phenyl, —S-lower alkyl, —S(O)2-lower alkyl, —N(R)—(CH2) | 09/07/2004 |
| 6780821 | Substituted phenyl uracils The invention relates to new substituted phenyluracils of the general formula (I) in which n, Q, R1, R2, R3, R4, R5 and X have the meanings given in the descr... | 08/24/2004 |
| 6734139 | N-aryl-uracile-based herbicides The present invention provides herbicidal active compound combinations which comprise, N-aryl-uracils and herbicidally active compounds and/or compounds which improve crop plant compatibility. The combinations find use in controlling monocotyledonous and dicotyledon... | 05/11/2004 |
| 6713486 | Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof 2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R1 is a C6-10 aryl or C3-10 heteroaryl group optionally havin... | 03/30/2004 |
| 6696475 | Substituted phenyl derivatives, their preparation and use The present invention discloses compounds having the formula ##STR1## wherein the substituents are defined in the application. The compounds are useful as chloride channel blockers.... | 02/24/2004 |
| 6664214 | Uracil compounds and use thereof The invention provides an uracil compound represented by the general formula: ##STR1## wherein W represents oxygen or sulfur; R1 represents C1 - to C3 -alkyl or C1 - to C3 -haloalkyl; R2 re... | 12/16/2003 |
| 6649760 | Substituted phenyluracils Phenyluracils of the general formula (I) ##STR1## in which Q, R1, R2, R3, R4, R5 and R6 each have one of the meanings given in the description, and processes for their preparation and th... | 11/18/2003 |
| 6624120 | Substituted herbicidal phenyluracils The invention relates to novel substituted phenyluracils of the general formula (I) ##STR1## in which m, n, Q, R1, R2, R3, R4, R5, X and Y are each as defined in the description, to processes ... | 09/23/2003 |
| 6620932 | 2-alkoxy-5-methoxypyrimidines or their tautomeric forms and methods for producing the same Novel 2-alkoxy-5-methoxypyrimidines and tautomeric forms thereof and also processes for preparing them are described. The 2-alkoxy-5-methoxypyrimidines according to the invention can be synthesized in few reaction steps and in high yields from simple ... | 09/16/2003 |
| 6613773 | Fungicides The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: ##STR1## wherein X is CH2 O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other is CH; T is oxygen or sulfur; and Z is an o... | 09/02/2003 |
| 6608197 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: ##STR1## wherein A, Q, R1, R2, R | 08/19/2003 |
| 6600044 | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising: (i) treatment of the cis-/trans-1,3-oxathiolane nucl... | 07/29/2003 |
| 6562759 | Substituted phenyl uracils The invention relates to novel substituted phenyluracils of the general formula (I) ##STR1## in which A represents alkanediyl or alkenediyl, each of which has 2 to 5 carbon atoms and each of which is optionally substituted by cyano, halogen or by in ... | 05/13/2003 |
| 6548449 | Substituted phenyluracils with herbicidal effect The invention relates to novel substituted phenyluraciles of the general formula (I) ##STR1## in which m, n, Q and R1-7 are each as defined in the description, and to processes for their preparation and to their use as herbicides.... | 04/15/2003 |
| 6545007 | Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrimidines A method for inhibiting sexual transmission of HIV comprising topically applying to the skin or epithelial tissue of a human a composition comprising a non-nucleoside reverse transcriptase inhibitor ("NNRTI") that is able to inhibit viral replication for ... | 04/08/2003 |
| 6537948 | Uracil compounds and use thereof The present invention relates to an uracil compound of the formula [I]: ##STR1## [wherein, Q--R3 represents a R3 -substituted group of a 5-membered or 6-membered heterocyclic ring having one or two nitrogen selected from the group co... | 03/25/2003 |
| 6534658 | 1,3,4-oxadiazole derivatives and process for producing the same Oxadiazole derivatives represented by formula (I): ##STR1## (wherein R1 represents a hydrogen atom or an amino-protective group; R2, R3, and R4 each independently represents an alkyl group, a cycloalkyl group, a... | 03/18/2003 |
