Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 7285533 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 10/23/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7119096 | Uracil reductase inactivators Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-flourouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, ido, cyano, halo-substituted C1-4 ... | 10/10/2006 |
| 7119202 | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties Disclosed are compounds of the formula wherein R1 is hydrogen or an acyl group having 1 to 16 carbon atoms; R2 is a purine or pyrimidine base or an analogu... | 10/10/2006 |
| 7115544 | Plant growth regulators for cotton hervest A plant growth regulator for cotton harvest, which contains as an active ingredient, a compound of formula (I): wherein X is CH or nitrogen; Z is halogen; A is oxygen, sulfur, or NH; R1 is hydroxyl, C | 10/03/2006 |
| 7109334 | Stereoselective methods for the preparation of nucleosides A process for producing predominantly cis nucleosides or nucleoside analogues and derivatives of formula (A): wherein R1 is a pyrimidine base or a pharmaceutically acceptable derivative thereof and Q is oxygen, c... | 09/19/2006 |
| 7078480 | Process for stabilizing the content of glycated protein of a sample on a matrix material The invention concerns a method for stabilizing the content of glycated protein in a sample on a matrix material, which is characterized in that the matrix material is impregnated with boric acid buffer with a pH which is larger or equal to 10.5 or a transition meta... | 07/18/2006 |
| 7034156 | Method for the production of 1-amino-3-phenyluracil derivatives The present invention relates to a novel process for preparing known 1-amino-3-phenyluracil derivatives, to novel 1-amino-6-hydroxy-3-phenyldihydro-2,4(1H,3H)pyrimidinedione derivatives of the formula (II) in which ... | 04/25/2006 |
| 7009050 | 5-Substituted pyrimidine derivatives of conformationally locked nucleoside analogues The embodiments described herein concern 5-substituted pyrimidine derivatives of conformationally locked nucleoside analogues and to the use of these derivatives as anti-viral and anti-cancer agents. The compounds are of the formula: | 03/07/2006 |
| 6967079 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; | 11/22/2005 |
| 6794384 | Hydroxylation activated drug release The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumor prodrugs and those which are specifically activate... | 09/21/2004 |
| 6794506 | 3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4 Disclosed are certain 3-(heteroaryl)alanine derivatives which bind VLA-4 and inhibit leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, a... | 09/21/2004 |
| 6780821 | Substituted phenyl uracils The invention relates to new substituted phenyluracils of the general formula (I) in which n, Q, R1, R2, R3, R4, R5 and X have the meanings given in the descr... | 08/24/2004 |
| 6746668 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 06/08/2004 |
| 6734139 | N-aryl-uracile-based herbicides The present invention provides herbicidal active compound combinations which comprise, N-aryl-uracils and herbicidally active compounds and/or compounds which improve crop plant compatibility. The combinations find use in controlling monocotyledonous and dicotyledon... | 05/11/2004 |
| 6713486 | Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof 2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against wild-type and mutant HIV-1 and low toxicity are useful for treating AIDS (I) wherein: R1 is a C6-10 aryl or C3-10 heteroaryl group optionally havin... | 03/30/2004 |
| 6686155 | Method of determining a chemotherapeutic regimen based on glutathione-S-transferase pi expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and ... | 02/03/2004 |
| 6677345 | Cyclin dependent kinase inhibitors A range is disclosed of pyrimidine derivatives (I) which can act as inhibitors of cyclin dependent kinases (CDK's) and which thereby can provide useful therapeutic compounds for use in treatment of tumours or other cell proliferation disorders. The compou... | 01/13/2004 |
| 6649760 | Substituted phenyluracils Phenyluracils of the general formula (I) ##STR1## in which Q, R1, R2, R3, R4, R5 and R6 each have one of the meanings given in the description, and processes for their preparation and th... | 11/18/2003 |
| 6624120 | Substituted herbicidal phenyluracils The invention relates to novel substituted phenyluracils of the general formula (I) ##STR1## in which m, n, Q, R1, R2, R3, R4, R5, X and Y are each as defined in the description, to processes ... | 09/23/2003 |
| 6600044 | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising: (i) treatment of the cis-/trans-1,3-oxathiolane nucl... | 07/29/2003 |
| 6562759 | Substituted phenyl uracils The invention relates to novel substituted phenyluracils of the general formula (I) ##STR1## in which A represents alkanediyl or alkenediyl, each of which has 2 to 5 carbon atoms and each of which is optionally substituted by cyano, halogen or by in ... | 05/13/2003 |
| 6548449 | Substituted phenyluracils with herbicidal effect The invention relates to novel substituted phenyluraciles of the general formula (I) ##STR1## in which m, n, Q and R1-7 are each as defined in the description, and to processes for their preparation and to their use as herbicides.... | 04/15/2003 |
| 6538001 | Crystalline modification of 5-fluoro-1-(tetrahydro-2-furyl) uracil and complex compounds based thereon, producing antineoplastic effect The invention relates to a novel, heretofore unknown polymorphous modification of 5-fluoro-1-(tetrahydro-2-furyl)uracil (tegafur) having antineoplastic activity. This form is crystalline, and its characteristics it differs essentially from the modificatio... | 03/25/2003 |
| 6518425 | Method of manufacture of 1,3-oxathiolane nucleosides Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the process... | 02/11/2003 |
| 6476224 | Method for producing ar(alk)yluraciles, novel corresponding intermediate products and method for producing said intermediate products The invention relates to a process for preparing ar(alk)yluracils of the general formula (I) ##STR1## in which A represents a single bond or represents alkanedlyl, Ar represents optionally substituted aryl, R1 represents optionally substituted alkyl... | 11/05/2002 |
| 6455697 | Substituted phenyluracils The invention relates to novel substituted phenyluracils of the general formula (I) ##STR1## in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to processes for thei... | 09/24/2002 |
| 6448203 | Substituted aryluracils The invention relates to novel substituted aryluracils of the formula (I): ##STR1## to processes for their preparation and to their use as crop protection agents.... | 09/10/2002 |
| 6444616 | Substituted p-trifluoromethylphenyluracils The invention relates to novel substituted p-trifluoromethylphenyluracils of the general formula (I) ##STR1## in which R1, R2, R3, R4 and R5 are each as defined in the description, to a process for th... | 09/03/2002 |
| 6440676 | Diagnostic assay for cancer The invention is directed towards gene expression characteristic for cancer, in particular brain cancers such as glioblastoma. Compositions, methods and kits encompassing such therein.... | 08/27/2002 |
| 6437126 | Substituted phenyluracils The invention is directed to a process for the preparation of a substituted phenyluracil of the formula: ##STR1## The process broadly comprises reacting a carbonylphenyluracil of the formula: ##STR2## with an amino compound, an alcohol or a mercaptan... | 08/20/2002 |
| 6417141 | Substituted aminouracils The invention relates to novel aminouracils of the general formula (I) ##STR1## in which, Q, R1, R2, R3, R4, R5, R6 and R7 are each as defined in the description, to their use as herb... | 07/09/2002 |
| 6417192 | Pyrimidinone compounds and pharmaceutical compositions containing them A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.... | 07/09/2002 |
| 6372691 | Method for controlling weeds The present invention relates to a method for controlling weeds in corn field which comprises applying a herbicidal composition comprising 2-[2-chloro-4-fluoro-5-{3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tet rahydropyrimidin-1-yl}phenoxy]propionic ac... | 04/16/2002 |
| 6362337 | Substituted phenyluracils The invention relates to substituted phenyluracils of the general formula (I) ##STR1## in which the radicals R1 to R5, Q and n are each as defined in the description, and to processes for their preparation and to their use as he... | 03/26/2002 |
| 6344460 | Propynyl uracils The present invention provides compounds comprising propynyl uracils having the formula ##STR1## wherein R1 is hydrogen, chlorine, bromine, iodine, fluorine, --CN, substituted or unsubstituted linear or branched C1 -C4 alk... | 02/05/2002 |
| 6313072 | Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines The novel compounds of formula I: ##STR1## (A, B, R1, R2, R3, X and m are defined in the specification) show selective herbicidal activity. The new compounds can be prepared according to known methods and can be used as he... | 11/06/2001 |
| 6306866 | Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents There are provided compositions and methods comprising compounds of formula I: ##STR1## wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.... | 10/23/2001 |
| 6297223 | Uracil reductase inactivatores Uracil reductase inactivators, notably a 5-substituted uracil or 5,6-dihydro-5-substituted uracil, potentiate 5-fluorouracil and find use particularly in the treatment of cancer. The 5-substituent is selected from bromo, iodo, cyano, halo-substituted C | 10/02/2001 |
| 6294535 | Uracil derivatives and antitumor effect potentiator and antitumor agent containing the same The invention relates to novel uracil derivatives having excellent inhibiting effects on human derived thymidine phosphorylates and anti-tumor activity. The pharmaceutical compositions, anti-tumor potentiators and antitumor agents containing such novel co... | 09/25/2001 |
