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| Number | Title | Issue Date |
| 7439240 | Purine-or pyrrolol[2,3-d]pyrimidine-2-carbonitiles for treating diseases associated with cysteine protease activity The present invention therefore provides a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases ... | 10/21/2008 |
| 7294624 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R... | 11/13/2007 |
| 7227021 | Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid The present invention provides a novel process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid. In particular, the present invention provides a process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid by reacting 1,3-bis(methoxymethyl)-5,5-dipheny... | 06/05/2007 |
| 7160893 | Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Q, R2, R3, and R4 are as defined in the spec... | 01/09/2007 |
| 7119201 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, W, and R1 are as defined in the specification, and to pharmace... | 10/10/2006 |
| RE39266 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compo... | 09/05/2006 |
| 7074925 | N-substituted derivatives of 5-oxyiminobarbituric acid N-substituted derivatives of 5-oximinobarbituric add of the general formula where X is sulfur; R1 is selected from the group consisting of saturated or unsaturated alkyl, cycloalkyl, aryl and arylalkyl; and ... | 07/11/2006 |
| 7064205 | Process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid The present invention provides a novel process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid. In particular, the present invention provides a process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid by reacting 1,3-bis(methoxymethyl)-5,5-dipheny... | 06/20/2006 |
| 6974872 | Process for production of piperidine derivatives The present invention discloses processes for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; | 12/13/2005 |
| 6953850 | Protecting groups for carbohydrate synthesis The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the... | 10/11/2005 |
| 6936620 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, W, Z, Ua, Xa, Y... | 08/30/2005 |
| 6919458 | Process for production of piperidine derivatives The present invention relates to a process for preparing piperidine derivative compounds of the formulae: wherein n is 0 or 1; R1 is hydrogen or hydroxy; ... | 07/19/2005 |
| 6914160 | Oxytocin inhibitors This invention relates to compounds of formula (I) ... | 07/05/2005 |
| 6835726 | Pyrimidine derivatives Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives. ... | 12/28/2004 |
| 6833372 | Non-peptide GnRH agents, Pharmaceutical compositions, and methods for their use Non-peptide GnRH agents that inhibit the effect of gonadotropin-releasing hormone are described. Such agents are useful for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonad... | 12/21/2004 |
| 6765089 | Protecting and linking groups for organic synthesis on solid supports This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and ... | 07/20/2004 |
| 6723843 | Oligosaccharide synthesis The invention provides a system for solid-phase synthesis of oligosaccharides, based on the discovery that a 2-substituted-1,3-dioxocycloalkyl linker group of general formula (I) can be used to couple saccharide groups of both the O-glycoside and N-glycoside type to... | 04/20/2004 |
| 6720421 | PHENYLURETHANE COMPOUNDS AND METHODS FOR PRODUCING SAME, ASYMMETRIC UREA COMPOUNDS AND METHODS FOR PRODUCING SAME, BARBITURIC ACID DERIVATIVE, AND DIAZO THERMAL RECORDING MATERIAL CONTAINING THE DERIVATIVE Phenylurethane compounds of the following general formula (1); asymmetric urea compounds of the following general formula (10) obtained from the phenylurethane compounds; barbituric acid derivatives of general formula (18) produced from the asymmetric urea compounds... | 04/13/2004 |
| 6706723 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, Y, A, B and R1 are as defined in the specification, and to pharmaceutical compositions and method... | 03/16/2004 |
| 6686367 | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## ##STR2## wherein Z1, Z2, R1, R2, R3, R4, R5, ... | 02/03/2004 |
| 6673925 | Method of producing thiobarbituric acid derivatives Method of producing thiobarbituric acid derivatives of formula I ##STR1## wherein R1 is SH, S- M+ or CH3 S--, and M+ is an alkali metal ion, by hydrogenolysis of a compound of formula II ##STR2## ... | 01/06/2004 |
| 6670367 | Azinyloxy, and phenoxy-diaryl-carboxylic acid derivatives, their preparation and use as mixed ETA/ETB endothelin receptor antagonists The invention relates to carboxylic acid derivatives of the formula I ##STR1## where the radicals have the meanings stated in the description, and to their use as drugs.... | 12/30/2003 |
| 6613773 | Fungicides The invention provides fungicidal compounds of formula (I) or stereoisomers thereof: ##STR1## wherein X is CH2 O; A is hydrogen; E is hydrogen; q is 1; any two of K, L and M are nitrogen and the other is CH; T is oxygen or sulfur; and Z is an o... | 09/02/2003 |
| 6608071 | Isoquinoline derivatives with angiogenesis inhibiting activity The invention relates to compounds of formula I ##STR1## wherein r is from 0 to 2; n is from 0 to 2; m is from 0 to 4; A, B, D and E are each independently of the others N or CH, with the proviso that not more than two of those radicals are N; G is lower alkyl... | 08/19/2003 |
| 6579982 | Pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula ##STR1## wherein X, Y, Ar1, Z, R1, R2 and R3 are as defined in the specification, and to pharmaceutical compos... | 06/17/2003 |
| 6562542 | Image-forming material and novel sulfonic acid ester derivative An image-forming material is described, comprising on an support an acid-generating agent selected from a sulfonic acid ester of a specific structure generating an acid by the action of heat and the polymer thereof, and a compound causing a light absorpti... | 05/13/2003 |
| 6552030 | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: ##STR1## wherein Z1, Z2, R1, R2, R3, R4, R5, R6 | 04/22/2003 |
| 6518425 | Method of manufacture of 1,3-oxathiolane nucleosides Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the process... | 02/11/2003 |
| 6452011 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## or ##STR3## and where m is 1 or 4-6; Q and Y are the... | 09/17/2002 |
| 6444682 | Base analogues Nucleotide or base analogues having structure (3) or (4) ##STR1## wherein X.dbd.O or NH or S and each R6 is independently H or alkyl or alkenyl or alkoxy or aryl or a reporter moiety.... | 09/03/2002 |
| 6444824 | Process for production of piperidine derivatives The present invention relates to a method for preparing piperidine derivative compounds by converting, with a piperidine compound, regioisomers having the formula: ##STR1## where Z is ##STR2## and where m is 1 or 3-6; Q and Y are the same or differen... | 09/03/2002 |
| 6417359 | Pharmaceutical compositions and methods for use A compound having the formula: ##STR1## wherein X' is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as ... | 07/09/2002 |
| 6380258 | Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl divalent aromatic or heteroa... | 04/30/2002 |
| 6335332 | Barbituric acid derivatives with antimetastatic and antitumor activity The invention is directed to barbituric acid derivatives having inhibitory activity for matrix maetalloproteases comprised of formula (I): ##STR1## pharmaceutical compositions thereof, processes for preparing the derivatives, and methods for treating dise... | 01/01/2002 |
| 6310069 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically accep... | 10/30/2001 |
| 6288071 | 1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.... | 09/11/2001 |
| 6281219 | Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof The present invention provides compounds of Formula I ##STR1## methods for their preparation and their use as acaricidal and insecticidal agents.... | 08/28/2001 |
| 6254669 | Bleed reduction agents for ink printing inks A compound of the Formula (1) and salts thereof: ##STR1## wherein: Ar, Ar1, J, J1, X, X1 W, W1, L and m are as defined in the description. The compounds of Formula (1) are useful as additives in inks, especially... | 07/03/2001 |
| 6235903 | Method for preparing sulfanyl-type endothelin receptor antagonists A process for preparing endothelin receptor antagonists of the sulfanyl type of the general formula I ##STR1## by nucleophilic reaction of a carboxylic acid derivative of the formula II with a sulfide of the formula III ##STR2## to give endothelin re... | 05/22/2001 |
| 6177437 | Inhibitors of Herpes Simplex virus uracil-DNA glycosylase The invention is directed to novel 6-aromatic substituted uracil compounds of formula I ##STR1## therapeutic compositions comprising the compounds, and methods of treating Herpes simplex virus Type I and Type II recurrent infections and Herpes simple... | 01/23/2001 |
