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| Number | Title | Issue Date |
| 8173806 | Method for production of quinazolin-4-one derivative In reacting an anthranilic acid derivative represented by the general formula (1), especially the anthranilic acid derivative selected from anthranilic acid, anthranilamide and anthranilate, with formamide, the reaction is attained under the condition of coexistence... | 05/08/2012 |
| 8133999 | Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one 6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate: ... | 03/13/2012 |
| 8003787 | Sulphoximine-substituted quinoline and quinazoline derivatives as kinase inhibitors The present invention relates to a quinoline or quinazoline derivative having the general formula (A): in which R3, R4, W, Y and Q are indicated in the description and the claims, the use of the compou... | 08/23/2011 |
| 7893260 | Substituted quinazolin-4-one compounds for antagonizing TRPV3 function The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. Suitable compounds include but are not limited to, for example, substituted quinazolin-4-ones of formula I. ... | 02/22/2011 |
| 7851623 | Chemical process The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture o... | 12/14/2010 |
| 7816527 | Quinazoline-containing kits for labeling aldehyde or ketone moieties Kits including novel fluorescent derivitization reagents for labeling an aldehyde- and/or ketone-containing target substance in a sample are described. In one embodiment kits are provided the novel fluorescent derivitization reagents of which have the following form... | 10/19/2010 |
| 7750154 | Amide derivatives The invention concerns a compound of the Formula (I) wherein m is 0-2 and each R1 is a group such as hydroxy, halogeno, trifluoromethyl heterocyclyl and heterocyclyloxy; R2 is halogeno, trifluoromethyl or (1-6C)alkyl; R3 is hydrogen,... | 07/06/2010 |
| 7671200 | Quinazolinone KSP inhibitors Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. ... | 03/02/2010 |
| 7442704 | Amide derivatives The invention concerns amide derivatives of Formula (Ia) wherein X is —NHCO— or —CONH—; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group su... | 10/28/2008 |
| 7381730 | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators Novel quinazoline derivatives possessing activity as estrogen receptor beta (ERβ) modulators are provided which have the general formula I wherein X is O or S; A and B ar... | 06/03/2008 |
| 7368453 | Quinazolinone compounds with reduced bioaccumulation A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the fol... | 05/06/2008 |
| 7364866 | G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention al... | 04/29/2008 |
| 7365199 | Dye-forming coupler, silver halide photographic light-sensitive material, and azomethine dye compound A dye-forming coupler of formula (I), a silver halide photographic light-sensitive material containing the coupler, and an azomethine dye compound derived from the coupler: wherein Q is a residue that forms, together with t... | 04/29/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7354724 | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention a... | 04/08/2008 |
| 7285557 | Pyrimidinones as melanin concentrating hormone receptor 1 A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided ... | 10/23/2007 |
| 7262201 | Quinazoline derivatives The invention relates to the use of compounds of the formula I: wherein: ring C is a 5-6 membered heterocyclic moiety; Z is —O—, —S—, or —CH2—; R1 is hydrogen, C1-4alk... | 08/28/2007 |
| 7259155 | Phosphonic diester derivatives The present invention provides a phosphonic acid diester compound represented by General Formula wherein R1, R2, R3 and R4 are the same or different, and represent hydr... | 08/21/2007 |
| 7253286 | Nitrogen-containing aromatic derivatives Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an... | 08/07/2007 |
| 7244738 | Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of makin... | 07/17/2007 |
| 7241767 | Quinazoline(di)ones for invertebrate pest control Compounds of Formula I including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof, are disclosed which are useful as invertebrate pest control agents, (I) wherein A, B, J, K, L and R3 are as defined in the disclosure. A... | 07/10/2007 |
| 7232903 | Process for producing quinazolin-4-one and derivatives thereof A process for preparing quinazolin-4-one or its derivative by reacting anthranilic acid or its derivative with formic acid or its derivative in the presence of ammonia, or by reacting ammonium anthranilate or its derivative with formic acid or its derivative. ... | 06/19/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7223768 | Fused ring heterocycles as potassium channel modulators Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and method... | 05/29/2007 |
| 7223756 | Quinazoline compounds with therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of m, R1, Z, n and R3 have any of the meanings defined in the description in the manufacture of a medicament for use in the prevention or treatment of T c... | 05/29/2007 |
| 7211580 | Compounds, compositions, and methods Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed. ... | 05/01/2007 |
| 7205309 | Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The... | 04/17/2007 |
| 7196194 | Dye-forming coupler, silver halide photographic light-sensitive material and azomethine dye compound A yellow dye-forming coupler represented by formula (I): wherein Q represents a group of nonmetallic atoms that form a 5- to 7-membered ring in combination with the —N═C—N(R1)—; R1 and... | 03/27/2007 |
| 7193080 | Dye-forming coupler, silver halide photographic light-sensitive material and azomethine dye compound A dye-forming coupler and compound of formula (I): wherein Q represents a residue that forms, together with —N—C═N—, a nitrogen-containing 6-membered ring; RA represents an aryl, heterocyclic, ... | 03/20/2007 |
| 7176312 | Kinase inhibitor scaffolds and methods for their preparation General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, bor... | 02/13/2007 |
| 7169789 | Quinoline derivatives and quinazoline derivatives An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions ... | 01/30/2007 |
| 7125863 | Inhibitors of dipeptidyl peptidase IV Compounds according to formula (1), wherein R1 is H or CN, X1 is S, O, SO2 or CH2, X2 is CO, CH2 or a covalent bond, Het is a nitrogen-containing heterocycle and n is 1–5 are new. The compounds of t... | 10/24/2006 |
| 7119199 | Process for the preparation of pyridopyrimidones The present invention is directed to a method for producing a pyridopyrimidone of the formula wherein X is N or CH and R is an aryl, heteroaryl or alkyl group, said method comprising the step of reacting an acid ... | 10/10/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
| 7115710 | Diagnosis and treatment of PTP related disorders The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ... | 10/03/2006 |
| 7105669 | Quinazoline derivatives A compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2 or NR10 where R10 is hydrogen or C1-6 alkyl, and R1, R2, R3, R4, R5, R | 09/12/2006 |
| 7105668 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. ... | 09/12/2006 |
| 7102005 | Compositions and methods for detection and isolation of phosphorylated molecules The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules... | 09/05/2006 |
| 7081460 | Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders The invention is directed to novel quinazoline and quinazoline-like derivatives of Formula (I): useful as integrin antagonists and methods for the treatment of integrin-mediated disorders. ... | 07/25/2006 |
| 7081461 | Quinazoline compounds and pharmaceutical compositions containing them The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, NH or NR8 where R8 is hydrogen or C1-6alkyl; | 07/25/2006 |
