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| Number | Title | Issue Date |
| 8058432 | Method for preparing phenylalanine derivatives having quinazoline-dione skeleton and intermediates for use in the preparation of derivatives The present invention releates to a method for preparing a phenylalanine compound having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof: ... | 11/15/2011 |
| 7737274 | Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising of reacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing... | 06/15/2010 |
| 7439249 | Inhibitors of phosphatases The present invention relates to compounds that inhibit phosphatases, compositions thereof, and methods of using those compounds and compositions for treating diseases. ... | 10/21/2008 |
| 7407963 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable p... | 08/05/2008 |
| 7368453 | Quinazolinone compounds with reduced bioaccumulation A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the fol... | 05/06/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7358257 | Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives whi... | 04/15/2008 |
| 7345049 | Phenylalanine derivatives Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. ... | 03/18/2008 |
| 7232902 | Process to prepare (1-carboxymethyl)-pyrimidinone compounds The invention relates to a process for the preparation of certain pyrimidinone compounds. ... | 06/19/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7205309 | Quinazoline derivatives Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The... | 04/17/2007 |
| 7173013 | Treatment of tuberculosis using immunomodulator compounds Tuberculosis in an animal is treated by administration of a therapeutically effective amount of an immunomodulator of formula A. In formula (A), n is 1 or 2, R is hydrogen, acyl, alkyl or a peptide fragment, and X is an aromatic or heterocyclic amino acid or a deriv... | 02/06/2007 |
| 7160874 | Phenylalanine derivatives Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. ... | 01/09/2007 |
| 7125995 | Substituted amidoalkyl uracils and their use as inhibitors of the poly(adp-ribose) synthetase (PARS) This application relates to compounds of formula (I) below in which the several variable groups are as defined in the specification and claims, to methods of preparing these materials, to pharmaceutical compositi... | 10/24/2006 |
| 7109332 | 2,4-dioxo-3-quinazolinylaryl sulfonylureas 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C1-6 alkyl; | 09/19/2006 |
| 7094780 | 3-aminoquinazolin-2,4-dione antibacterial agents Antibacterial 3-aminoquinazolin-2,4-diones have formula (I) wherein: R1 and R3 include alkyl, alkenyl, cycloalkyl, aryl, hetero-cyclic, and heteroaryl; R5, R6, and R8 include H, alkyl, alkoxy, halo, NO2 | 08/22/2006 |
| 7060825 | Process for synthesizing 6-quinazolinyl-ethyl-benzoyl and related antifolates The invention claimed herein relates to an improvement in a process for synthesizing a compound of formula Ib: wherein R1 and R2 are each individually amino or N-alkyl substituted amino; hydroxy; alkoxy; keto;... | 06/13/2006 |
| 7056926 | Platelet ADP receptor inhibitors Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives whi... | 06/06/2006 |
| 7049438 | Quinazoline derivatives for treatment of tumours The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, m, R1, R2, R3 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical comp... | 05/23/2006 |
| 7037880 | Ethylene derivatives and pesticides containing said derivatives Ethylene derivatives of formula (I): where Q is an unsubstituted or substituted phenyl or heterocyclic group, especially a 4-thiazolyl, 1- or 3-pyrazolyl, 1,3-oxazol-4-yl, phenyl or pyridyl group; E is a substituent su... | 05/02/2006 |
| 6921766 | Blood vessel lipid deposition-preventive agent comprising chymase-inhibitor There is provided a preventive or therapeutic agent for diseases accompanied by abnormal vascular function in which lipid deposition in the blood vessel is involved, said agent comprising a chymase inhibitor as an active ingredient. As the chymase inhibitor, ... | 07/26/2005 |
| 6900222 | Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein —Z1—Z2 | 05/31/2005 |
| 6872727 | Polycyclic pyrimidine -2,4(1H,3H)-diones with functionalized alkyl residues at the 1- and/or 3-position(s); methods for their synthesis and pharmaceutical preparation Polycyclic pyrimidine-2,4(1H,3H)-diones with functionalized alkyl residues at the 1-, the 3-, or both position(s); methods for their synthesis, production, and pharmaceutical preparation. The invention concerns the synthesis of the above-described compounds, their c... | 03/29/2005 |
| 6867214 | Quinazoline derivatives and pharmaceutical applications thereof A quinazoline derivative having formula (1) and a pharmaceutically acceptable salt thereof: wherein the ring A represents an aryl group, which derivative has a chymase inhibitory acti... | 03/15/2005 |
| 6806274 | Quinazoline derivatives The invention concerns quinazoline derivatives of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X | 10/19/2004 |
| 6689786 | Platelet ADP receptor inhibitors Novel compounds of formula (I) to (VI), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivat... | 02/10/2004 |
| 6683101 | Bicyclic cyclohexylamines and their use as NMDA receptor antagonists Described are heterocycle-substituted cyclohexylamines of formula (I), and their pharmaceutically acceptable salts thereof. The compounds of the formula (I) are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders... | 01/27/2004 |
| 6521630 | Tetrahydroquinazoline-2,4-diones and therapeutic uses thereof The present invention relates to tetrahydroquinazoline-2,4-diones derivatives of the formula (I): ##STR1## pharmaceutically acceptable salts thereof, wherein A is (CH2)n where n is equal to 0, 1 or 2; U is CH2, NH, or NR | 02/18/2003 |
| 6498172 | Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t... | 12/24/2002 |
| 6495547 | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties The present invention of compounds of formula (I) ##STR1## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk1 is C1-6 alkanediyl optionally subs... | 12/17/2002 |
| 6448270 | 4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions... | 09/10/2002 |
| 6436925 | Substituted benzamides, their production and their use as cysteine protease inhibitors Benzamides of the formula I ##STR1## and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meanings: R1 --C1 -... | 08/20/2002 |
| 6429311 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis... | 08/06/2002 |
| 6413724 | Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of ... | 07/02/2002 |
| 6407116 | Nitrogenous fused-ring compounds, process for the preparation of the same, and drugs A compound represented by the formula: ##STR1## [wherein ring A represents a homocycle optionally having substituents or a nitrogen-containing heterocycle optionally having substituents; D and E are O or S; one of R1 and R2 represent... | 06/18/2002 |
| 6376667 | Solid phase synthesis of heterocycles Methods and compounds for the synthesis of heterocycles, including pyrimidine-2,4-diones, are disclosed. Also disclosed are solid supports useful for solid phase synthesis, and methods for making the solid supports.... | 04/23/2002 |
| 6369002 | N-heteroaryl-substituted pyridine derivatives and their use as herbicides Compounds of formula 1 ##STR1## wherein ##STR2## R1 is hydrogen, fluorine, chlorine, bromine or methyl; R2 is C1 -C4 alkyl, C1 -C4 halogenalkyl, halogen, hydroxy, C1 -C4 | 04/09/2002 |
| 6344559 | Process for producing quinazoline derivatives This invention provides an industrially useful process for producing a quinazoline derivative (I) of the general formula: ##STR1## [wherein R1 is hydrogen or halogen; R2 is carboxy or protected carboxy; A is lower alkylene] or its sa... | 02/05/2002 |
| 6339044 | N-P-Cyanoaryl nitrogen-containing heterocycles having pendent sulfur-containing groups N-Cyanoaryl nitrogen heterocycles having sulfur-containing groups of the formula (1), ##STR1## in which Q1 represents oxygen or sulfur, R1 represents hydrogen or halogen, R2 represents halogen, cyano, nitro, amino or the groupi... | 01/15/2002 |
| 6277987 | Sulfonylamino acid and sulfonylamino hydroxamic acid derivatives Compounds of formula ##STR1## wherein W is --OH or --NHOH; X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)m moiety by a ring nitrogen, --CONR2 ... | 08/21/2001 |
