Class 544/279 - Three ring nitrogens in the bicyclo ring system

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the bicyclo ring system contains three
No. of patents: 448
Last issue date: 03/27/2012

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Number	Title	Issue Date
8143394	Pyrido(3,2-d)pyrimidines useful for treating viral infections 2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or prevention of an infection due to a virus from the Flaviviridae family, especially HCV, when administered to a ...	03/27/2012
8071766	HSP90 inhibitors The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture compris...	12/06/2011
8039618	Method for producing bicyclic guanidines by use of a cyclic urea The present invention is directed to a method for producing bicyclic guanidines comprising heating a cyclic urea to a temperature >200° C. to form the bicyclic guanidines. ...	10/18/2011
7915264	Fused pyridine derivatives for use as vanilloid receptor antagonists for treating pain The invention provides compounds of formula (I) wherein R1, R2, R3, R4, and R5 are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.	03/29/2011
7915411	Anti-viral compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or t...	03/29/2011
7893259	Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of ena...	02/22/2011
7842806	Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof The disclosure relates to pyrido[2,3-d]pyrimidone compounds, to the preparation thereof and to the therapeutic use thereof, wherein said compounds are of general formula (I): in the form of a base or of an addition salt wit...	11/30/2010
7820816	Process for the synthesis of CMHTP and intermediates thereof The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hy...	10/26/2010
7816526	Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an opt...	10/19/2010
7781583	Synthesis of 2-(pyridin-2-ylamino)-pyrido[2,3-d] pryimidin-7-ones The present invention provides methods of preparing substituted 2-(pyridin-2-ylamino)-pirido[2,3-d]pyrimidin-7-ones (formula 1), useful in treating cell proliferative disorders, or a pharmaceutically acceptable salt thereof...	08/24/2010
7777033	Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof The present invention relates to a monomer with anti-microbial characteristics, a polymeric compound with anti-microbial characteristics using the same, and manufacturing methods thereof, and more particularly, to an antimicrobial monomer comprising a saturated or u...	08/17/2010
7601836	Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7 Pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors are provided which are useful in treating T-cell mediated diseases, said inhibitors include: (i) 2-[[4-[[[4-(Aminosulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-4-methyl-5-t...	10/13/2009
7550589	6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as wel...	06/23/2009
7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R...	10/28/2008
7429594	Substituted heterocyclic compounds and methods of use The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 ato...	09/30/2008
7423042	Compounds This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and p...	09/09/2008
7407962	Heteroaryl compounds useful as inhibitors or protein kinases The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmac...	08/05/2008
7407963	Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable p...	08/05/2008
7393853	Use of substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-] pyrimidin-4-one derivatives as therapeutic agents The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states...	07/01/2008
7388005	Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo [1,2-a]pyrimidin-5(1H)one derivatives for neurodegenerative disorders The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; y represents a bond, an ethenylene group, an ...	06/17/2008
7388019	3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV en...	06/17/2008
7378423	Pyrimidine compound and medical use thereof The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeuti...	05/27/2008
7375102	Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subje...	05/20/2008
7371750	Compounds and compositions as protein kinase inhibitors The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or d...	05/13/2008
7361662	Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a phar...	04/22/2008
7348331	Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in trea...	03/25/2008
7345171	Isethionate salt of a selective CKD4 inhibitor Disclosed are polymorphs of the isethionate salt of 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, which is a selective cyclin-dependent kinase 4 (CDK4) inhibitor use...	03/18/2008
7345045	Pyrido-pyrimidine compounds as medicaments The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formula or the pharmaceutically acceptable salts thereof wherein R3 is a nonin...	03/18/2008
7345040	Reverse-turn mimetics and compositions and methods relating thereto Reverse-turn mimetics and methods relating to the same having the following structure are disclosed: including pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3	03/18/2008
7332498	Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts there...	02/19/2008
7329664	Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with ...	02/12/2008
7323472	2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof. ...	01/29/2008
7320987	6-Alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or C...	01/22/2008
7314873	(Halo-benzo carbonyl)heterobi cyclic p38 linase inhibiting agents Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (I) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty ar...	01/01/2008
7314881	2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ...	01/01/2008
7312330	Bicycloheteroarylamine compounds as ion channel ligands and uses thereof Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of condi...	12/25/2007
7303750	Methods to improve immunogenicity of antigens and specificity of antibodies A method of improving specific immune response to small immunogens, haptens, has been developed by changing the linkage between the hapten and carrier being used for immunization. High affinity antibodies to cotinine have been produced using this method. Antibodies ...	12/04/2007
7279484	Heterocyclic compounds The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent...	10/09/2007
7271181	Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut...	09/18/2007
7265123	Heterocyclic compounds Heteroaromatic compounds are described, methods for their preparation, pharmaceutical compositions containing them, methods of use, and their use in medicines. In particular, the invention relates to quinazoline and pyridopyrimidine derivatives which exhibit protein...	09/04/2007

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Class 544/279 - Three ring nitrogens in the bicyclo ring system