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| Number | Title | Issue Date |
| 7786300 | Process for preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation. ... | 08/31/2010 |
| 7511139 | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation Processes for preparing entecavir and novel intermediates thereof using carbon-silicon oxidation. ... | 03/31/2009 |
| 7468436 | Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers. The nucleoside enantiomer (−)-2-hydroxymethyl-5-(5-f... | 12/23/2008 |
| 7439359 | Small molecule compositions for binding to hsp90 Structural differences in binding pockets of members of the HSP90 family can be exploited to achieve differential degradation of kinases and other signaling proteins through the use of designed small molecules which interact with the N-terminal binding pocket with a... | 10/21/2008 |
| 7432272 | Antiviral analogs The application relates to 4′-substituted nucleoside derivatives of Formula I: wherein B and R1 have any of the values described in the application, as well as to compositions comprising such compounds, to meth... | 10/07/2008 |
| 7427616 | Condensed pyridines and pyrimidines with tie2 (TEK) activity A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G ... | 09/23/2008 |
| 7407962 | Heteroaryl compounds useful as inhibitors or protein kinases The present invention provides compounds that are inhibitors of protein kinase, particularly inhibitors of ERK2, GSK3, PKA, CDK2 protein kinases, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmac... | 08/05/2008 |
| 7371737 | 2-substituted-6-trifluoromethyl purine derivatives with adenosine-Aantagonistic activity The present invention relates to 2-substituted-6-trifluoromethyl purine derivatives as selective adenosine antagonists, in particular adenosine-A3 receptor antagonists, to methods for the preparation of these compounds and to novel intermediates useful fo... | 05/13/2008 |
| 7368437 | Bicyclic heterocycles, processes for their preparation and their use as herbicides and pharmaceutical agents Methods and compounds for inhibiting the enzymes adenosine monophosphate deaminase or adenoside deaminase are provided. Such methods and compounds are useful in agriculture, horticulture and/or pharmacology as, for example, active compounds for crop protection or ph... | 05/06/2008 |
| 7368086 | Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi... | 05/06/2008 |
| 7358273 | Inhibitors of caspases The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1β converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and... | 04/15/2008 |
| 7351827 | Substituted oxetanes, method of making, and method of use thereof Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside analog related disorders such as disorders involving cellular proliferation... | 04/01/2008 |
| 7335654 | Phosphodiesterase 4 inhibitors PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein. ... | 02/26/2008 |
| 7321035 | Process for producing 2,6-dihalogenopurine A process for conveniently and efficiently preparing a 2,6-dihalogenopurine using an inexpensive starting material. A process for preparing a 2,6-dihalogenopurine, comprising treating a 2-amino-6-halogenopurine having a protective group at 7th position or... | 01/22/2008 |
| 7317018 | Anti-inflammatory medicament The use of adenosine-5′-triphosphate-2′,3′-dialdehyde (oATP) as a medicament useful for the treatment of inflammatory conditions is disclosed. ... | 01/08/2008 |
| 7312229 | 21-Heterocyclic-4-azasteroid derivatives as androgen receptor modulators Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the ute... | 12/25/2007 |
| 7307167 | Production method of 2,6-dihalopurine By reacting the compound of the formula [Ia] or [Ib] with halosilane compound and an agent for diazo reaction, 2,6-dihalopurine of the formula [II] can be produced conveniently in a high yield and can be easily isolated, wherein each symbol is as defined in the spec... | 12/11/2007 |
| 7300923 | Partial and full agonists of A1 adenosine receptors Disclosed are syntheses suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infa... | 11/27/2007 |
| 7285288 | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 n... | 10/23/2007 |
| 7285558 | Pyrazolo[3,4-d]pyrimidines inhibiting infections Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection. ... | 10/23/2007 |
| 7271157 | Aadenosine receptor agonists Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonist having the structure of Formula I: wherein R is optionally subst... | 09/18/2007 |
| 7256196 | Purine cytokine inhibitors The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions c... | 08/14/2007 |
| 7256275 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ... | 08/14/2007 |
| 7253154 | Substituted thiazolopyrimidines as xanthine oxidase inhibitors The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which m... | 08/07/2007 |
| 7244847 | Benzimidazole compounds The present invention is directed to novel benzimidazoles according to representative structures I and II, and their derivatives that possess antibacterial activity. This invention is also directed to compositions including the benzimidazole derivatives, and methods... | 07/17/2007 |
| 7223879 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. ... | 05/29/2007 |
| 7217720 | 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uteru... | 05/15/2007 |
| 7211667 | Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of m... | 05/01/2007 |
| 7192932 | Use of immunomodulating agents Pharmaceutical compositions useful for treating immunosuppressive disease and containing compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) as well as use of the same, are described. ... | 03/20/2007 |
| 7189730 | Aadenosine receptor antagonists Disclosed are novel A2A adenosine receptor antagonists of the formula: wherein: R1 is optionally substituted aryl or optionally substituted heteroaryl; | 03/13/2007 |
| 7176312 | Kinase inhibitor scaffolds and methods for their preparation General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, bor... | 02/13/2007 |
| 7148226 | Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The ... | 12/12/2006 |
| 7148223 | 4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof Compounds represented by the formula 1: A is selected from the group consisting of wherein each R individually is H or... | 12/12/2006 |
| 7138399 | Alkoxypyridine-derivatives The compounds of formula I in which R1 is 1–4C-alkoxy, A is 1–4C-alkylene, B represents 3H-imidazo[4,5-b]pyridin-2-yl, 3H-imidazo[4,5-b]pyridin-2-yl substituted by R2 and/or R3, 9H-purin-8-yl or 9H-purin-8-yl... | 11/21/2006 |
| 7135564 | Reusable solid support for oligonucleotide synthesis A reusable linker arm for solid support oligonucleotide synthesis, the linker arm comprising formula (a) wherein Z is a linker moiety and T is an organic radical. A method for adding one or more nucleosides on the linker arm is also described | 11/14/2006 |
| 7129239 | Purine compounds and uses thereof Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein. ... | 10/31/2006 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7098197 | Phosphonate compounds The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and th... | 08/29/2006 |
| 7094772 | Phosphonate compounds The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and th... | 08/22/2006 |
| RE39112 | Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine compound represented by the formula (I), its pharmacologically... | 05/30/2006 |
