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Class 544/263 - Ring nitrogen is shared by two cyclos


Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which a ring nitrogen is a member of both of
No. of patents: 209
Last issue date: 02/28/2012


1            
NumberTitleIssue Date
8124760Pyridyl-triazolopyrimidine derivative or its salt, pesticide containing it and its production process
To provide a novel pesticide. The present invention provides a pesticide containing a pyridyl-triazolopyrimidine derivative represented by the formula (I) or its salt as an active ingredient: wherein R1 is substitutable alkyl, substitutable cycloalkyl, su...
02/28/2012
7781582Process for the preparation of 2-amino-[1,2,4]triazolo[1,5-a]pyrimidines
Process for the preparation of unsubstituted or substituted 2-amino-[1,2,4]triazolopyrimidines which comprises combining A) 2-amino-pyrimidine or its derivatives with alkyloxycarbonyl isothiocyanate or aryloxycarbonyl isothiocyanate with B) hydroxyl ammonium salt an...
08/24/2010
7419982Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
The present invention relates to crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts; processes for the production thereof; pharmaceutical compositions th...
09/02/2008
7417041Imidazopyrimidines as transforming growth factor (TGF) inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of tran...
08/26/2008
7396835Process for the preparation of tubulin inhibitors
The present invention provides a process for the preparation of 6-[(substituted)phenyl]-triazolopyrimidine dicarboxylic acid salt and as a hydrated salt having the structural formula (I) wherein: R1 ...
07/08/2008
RE40332Fungicidal trifluoromethylalkylamino-triazolopyrimidines
The novel compounds of formula I: wherein (R1, R2, Hal and L1 through L5 are defined in the specification) show selective fungicidal activity. The new compounds may be processed with ca...
05/20/2008
7361656Prenyl transferase inhibitors
A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH
04/22/2008
7351826Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds
The invention provides compounds of Formula (I) that bind to GABAA receptors. In the above formula, variables are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly...
04/01/2008
7339058Process for the preparation of -([1,2,4]triazolopyrimidin-2-yl)aryl sulfonamides
The N-arylsulfilimine-catalyzed coupling of aromatic sulfonyl chlorides with N-([1,2,4]triazolopyrimidin-2-yl)amines to form N-([1,2,4]triazolo-pyrimidin-2-yl)aryl sulfonamides is improved by the selection of 3-picoline or 3,5-lutidine as the base. ...
03/04/2008
7329663Substituted-triazolopyrimidines as anticancer agents
The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pha...
02/12/2008
7300908Fungicidal triazolopyrimidines, method for the production thereof and use thereof in controlling noxious fungi and agents containing said compounds
Triazolopyrimidines of formula (I), wherein the index and substituents have the following meaning: n=0 or a whole number of 1-5; R=halogen, cyano, hydroxy, cyanate, alkyl, alkenyl, alkinyl, halogenalkyl, halogenalkenyl, alkoxy, alkenyloxy, alkinyloxy, halogenalkoxy,...
11/27/2007
7271170Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands
Compounds of Formula I are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and ...
09/18/2007
7238212Imidazole compounds and use of these compounds for dyeing keratinous fibers
The disclosure relates to novel imidazole compounds which can be useful as couplers for the oxidation dyeing of keratinous fibers. The present disclosure also relates to a dyeing composition for dyeing keratinous fibers comprising at least one oxidation base and at ...
07/03/2007
7205316Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R...
04/17/2007
71896805-halo-6-aryl[1,2,4]triazolo[1,5-a]pyrimidin-7-amines
The invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3 and X have the meanings given in the disclosure, and acid addition s...
03/13/2007
71868315-halo-2-alkyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amines
This invention relates to novel triazolopyrimidines of the formula in which R1, R2, R3, R4and X have the meanings given in the disclosure, to a...
03/06/2007
7151105Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected...
12/19/2006
7148227Fungicidal triazolopyrimidines, methods for producing the same, use thereof for combating harmful fungi and agents containing said substances
The invention relates to triazolopyrimidines of formula (I), in which the substituents are defined as follows: L1 represents cyano, S(═O)nA1 or C(═O)A2, wherein A1 stands for hydrogen, hydroxy, alkyl, alkyla...
12/12/2006
71056645-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
5-Halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines of formula I: (I) in which R1 is hydrogen, fluoro, alkyl, alkenyl, alkynyl, alkadienyl, where the carbon chains of these radicals may be unsubstituted or substituted as defined in the description; ...
09/12/2006
7094894Fungicidal triazolopyrimidines, method for the production thereof, use thereof for controlling harmful fungi, and agents containing said fungicidal triazolopyrimidines
Disclosed are a method for producing fungicidal triazolopyrimidine compounds, agents containing said compounds, and the use thereof for controlling harmful fungi. Also disclosed are triazolopyrimidines of formula (I), in which the substituents have the following mea...
08/22/2006
7094782Azolo triazines and pyrimidines
Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascu...
08/22/2006
7091209Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors
A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and taut...
08/15/2006
7084135Prenyl transferase inhibitors
A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by formula (I): wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12
08/01/2006
7084146Fungicidal trifluoromethylalkylamino-triazolopyrimidines
The novel compounds of formula I: wherein R1 is hydrogen or methyl; R2 is hydrogen, or an optionally substituted alkyl, alkenyl, alkynyl, alkadienyl or phenyl group...
08/01/2006
7078408[1,2,4]-Triazole bicyclic adenosine A2a receptor antagonists
Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1–C6)-alkyl, halo,...
07/18/2006
70713346-(2-chloro-6-fluoro-phenyl)-triazolopyrimidines
6-(2-Chloro-6-fluoro-phenyl)-triazolopyrimidines of formula (I), in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, alkadienyl, or haloalkyl, cycloalkyl, bicycloalkyl, phenyl, naphthyl, or 5- or 6-membered heterocyclyl...
07/04/2006
7067520Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
The present invention provides a preventive or therapeutic medicine for diabetes containing as an active ingredient a fused-heterocyclic compound of the formula (I′) or its salt: [wherein G is CN, NO2
06/27/2006
7041666Adenosine A2a receptor antagonists
Disclosed are compounds having the structural formula or pharmaceutically acceptable salts or solvates thereof, wherein R is optionally substituted heteroaryl, optionally substituted ...
05/09/2006
7041667CCR5 modulators
Compounds of Formula 1 [Region α]—[Region β]—[Region γ]—[Region δ]  (1) which are useful as modulators of chemokine activity. The invention also provides pharmaceutical formulations and m...
05/09/2006
7038047Substituted 6-(2-methoxyphenyl) triazolopyrimides as fungicides
Substituted 6-(2-methoxy-phenyl)-triazolopyrimidines of formula I in which R1 and R2 independently denote hydrogen or alkyl, alkenyl, alkynyl, or alkadienyl, halo...
05/02/2006
6992188Substituted heterocyclic derivatives
Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R3, and R5 having the definitions set forth in the specification pharmaceutical com...
01/31/2006
6958341Pyrazolopyrimidines as CRF antagonists
The present invention relates to pyrazolopyrimidines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl specie...
10/25/2005
6921762Substituted indolizine-like compounds and methods of use
Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodr...
07/26/2005
6911443Imidazopyrimidine derivatives and triazolopyrimidine derivatives
A compound of the formula (I) in which R1 is —OR11, —SR11, —SOR11, —SO2R11, —NHR11, or —NR12R13 , and R
06/28/2005
6911442Quinoline derivatives as antibacterials
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or N-oxide thereof: corresponding novel medicaments, pharmaceutical compositions and/or methods of ...
06/28/2005
6900217Substituted 6,5-hetero-bicyclic derivatives
This invention relates to compounds of the formula wherein A, B, D, E, K, T, G, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds. ...
05/31/2005
6875772[1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists
Compounds having the structural formula I wherein: n is 0, 1, 2 or 3; A is C(R1) or N; R1 and R1a are H, (C1
04/05/2005
68557187-(r)-aminotriazolopyrimidines, the production thereof and use of the same for combatting phytopathogenic fungi
A 7-(R)-Aminotriazolopyrimidines of formula I where the substituents and index are as defined below: R1 is hydrogen or methyl; R2 is methyl;
02/15/2005
6828326Pyrimidinone fused bicyclic metalloproteinase inhibitors
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical comp...
12/07/2004
6806268Method for treating glaucoma V
Provided, among things, is a method of decreasing intraocular pressure in an animal, including a human, comprising administering an intraocular pressure decreasing amount of a compound of the formula IA and or IB: ...
10/19/2004
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