Famous Patents
Pong, the Atari creation that launched the computer game craze, came with these instructions: "Avoid missing ball for high score."
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8003786 | Dihydropteridinone compounds Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for... | 08/23/2011 |
| 7348331 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in trea... | 03/25/2008 |
| 7169794 | 6-substituted pyrido-pyrimidines The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, a... | 01/30/2007 |
| 7033594 | Method of treatment using ligand-immunogen conjugates A method and pharmaceutical composition are provided for enhancing the endogenous immune response-mediated elimination of a population of pathogenic cells in a host animal wherein the pathogenic cells preferentially express, uniquely express, or overexpress a bindin... | 04/25/2006 |
| 6936612 | 2-(Pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4) ... | 08/30/2005 |
| 6858731 | Process for the preparation of pure stereoisomers of tetrahydrofolic acid esters salts and tetrahydrofolic acid by fractionated crystallization of tetrahydrofolic acid esters salts A process for preparing and concentrating (6S,αS) or (6S,αR) tetrahydrofolic acid ester salts and (6S,αS) or (6S,αR) tetrahydrofolic acid, characterized by preparing or dissolving equimolar or concentrated mixtures of diastereomers of addition salts of tetrahydr... | 02/22/2005 |
| 6709679 | Antineoplastic conjugates of transferin, albumin and polyethylene glycol Conjugates of transferrin, albumin and polyethylence glycol consisting of native or thiolated transferrin or albumin or of polyethylene glycol (MW between approximately 5,000 and 20,0000) with at least one HS—, HO— or H2N group and cytostatic compound... | 03/23/2004 |
| 6696566 | 6-substituted pyrido-pyrimidines The present invention provides compounds of the Formula I and II: ##STR1## wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their ... | 02/24/2004 |
| 6458950 | Compounds and pharmaceutical compositions containing the same A compound shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R1 is hydrogen,... | 10/01/2002 |
| 6358953 | Pterin antineoplastic agents Disclosed are novel metal pterin and pterin analog complexes and compositions useful as antineoplastic and antiviral agents.... | 03/19/2002 |
| 6348593 | Process for preparing folic acid A process for preparing folic acid, which comprises reacting a tetraalkoxypropanol of the general formula I, ##STR1## in which the substituents R are C1 -C4 -alkyl, with triaminopyrimidone of the formula II and p-aminobenzoyl-L-gluta... | 02/19/2002 |
| 6297245 | Cisplatin and folic acid administered to treat breast cancer A novel pharmaceutical composition, comprising cisplatin and folic acid is disclosed. The preparation of this pharmaceutical composition is also disclosed. The composition may be used to treat cancers and Acquired Immune Deficiency Syndrome (AIDS).... | 10/02/2001 |
| 6291673 | Folic acid derivatives Novel folic acid derivatives and their use in preparation of γ-esters of folic acid via a pteroyl azide intermediate are described. Folic acid γ-esters are useful intermediates in the synthesis of folic acid conjugates capable of binding folate receptor... | 09/18/2001 |
| 6203818 | Nutritional supplement for cardiovascular health A nutritional supplement for improving cardiovascular health via aiding in preventing, delaying the onset of and/or slowing the progression of atherosclerosis and coronary heart disease, the supplement comprising one or more flavonoids and folic acid or f... | 03/20/2001 |
| 6143743 | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders Corticotropin releasing factor (CRF) antagonists of formula (I): ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders a... | 11/07/2000 |
| 5997915 | Compositions for human and animal consumption containing reduced folates and methods for making and using same A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic... | 12/07/1999 |
| 5902810 | Pteridine derivatives as no synthase inhibitors The present invention relates to the use of pteridine derivatives of the formula I ##STR1## in which X is O, NH or N--(C1-C.sub.5)-alkanoyl, R3 is the radical --OR4, --NR5 R6 or --S(O)m | 05/11/1999 |
| 5889006 | Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R1, R2, R3, R4, R21, R... | 03/30/1999 |
| 5874433 | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine or, 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine)... | 02/23/1999 |
| 5807854 | Pyrimidone derivatives with antifungal activity Compounds of general formula I and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these compounds and processes for their preparation are also prov... | 09/15/1998 |
| 5693641 | Bicyclic pyrimidine derivatives and their use as anti-coagulants This invention is directed to bicyclic pyrimidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat diseas... | 12/02/1997 |
| 5538734 | 5-methyltetrahydrofolic acid, 5-formyl-tetrahydrofolic acid and their pharmaceutically acceptable salts for use in the therapy of depressive disturbances The present invention refers to the use of 5-methyltetrahydrofolic acid, of 5-formyltetrahydrofolic acid and of their pharmaceutically acceptable salts for the preparation of controlled release pharmaceutical compositions suitable for the use in the thera... | 07/23/1996 |
| 5470960 | Phenylalanine-glycine derivatives, process for preparation thereof, and pharmaceutical composition containing said derivatives A phenylalanine-glycine derivative of the general formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are ... | 11/28/1995 |
| 5410056 | Method for the production of folic acid The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This di... | 04/25/1995 |
| 5340832 | Prolinal derivatives useful for treating amnesia A novel prolinal derivative of the general formula: ##STR1## [wherein A represents alkylene or alkenylene group of from 1 to 8 carbon atom(s) or a saturated hydrocarbon ring of from 3 to 7 carbon atoms, R represents hydrogen atom, phenyl group, benzy... | 08/23/1994 |
| 5241070 | Nucleophilic polysubstituted aryl acridinium esters and uses thereof This invention is directed to novel nucleophilic polysubstituted aryl acridinium esters and to novel conjugates thereof. The novel nucleophilic polysubstituted aryl acridinium esters and novel conjugates thereof are useful in biological assays, including ... | 08/31/1993 |
| 5198547 | Process for N5-formylating tetrahydropteridines Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as follows: ##STR1## wherein R1 and R... | 03/30/1993 |
| 5196533 | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines 6,6-Disubstituted pteridines which are useful for the regulation of enzymes are disclosed, along with a general method of synthesizing these compounds.... | 03/23/1993 |
| 4997924 | 5'-deoxy-4',5'-unsaturated-5'-substituted adenosines This invention relates to certain aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.... | 03/05/1991 |
| 4985171 | Anthraquinone type compound and liquid crystal composition containing such compound An anthraquinone type compound which is represented by the following general formula (I) and which exhibits yellow to orange-colored hue; and a composition for liquid crystal display element obtained by dissolving the compound into liquid crystal: ##... | 01/15/1991 |
| 4931442 | Stabilized aqueous folic acid preparation This invention relates to a stabilized aqueous folic acid preparation which comprises a folic acid component selected from the group consisting of folic acid, ammonium, alkali metal and alkaline earth metal salts of folic acid and mixtures thereof, and wh... | 06/05/1990 |
| 4820706 | Pteridine derivatives and method of treating leukemia employing same 2,4-Diaminopteridine derivatives and the pharmaceutically acceptable salts thereof having potent anticancer activity are disclosed. The derivatives possess the structural formula: ##STR1## wherein Y is NH2, OH or SH, R is ##STR2## ... | 04/11/1989 |
| 4772606 | Purine derivatives Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are ... | 09/20/1988 |
| 4350659 | Stabilization of sensitive biologically active intermediate metabolites such as folic acid derivatives A sensitive intermediate metabolite such as a folic acid derivative or analog is stabilized by complexing it with a complementary binder or receptor such as a protein and then lyophilizing the complex. An example of such a folic acid derivative is N-5-met... | 09/21/1982 |
| 4336185 | Folic acid derivatives Novel protein conjugates and radioiodinated derivatives of folic acid and salts, esters and amides useful in the radioimmunoassay (RIA) of body fluids to determine folic acid are disclosed.... | 06/22/1982 |
| 4248871 | N-9,10-Dihydrolysergyl-m-aminobenzoic acid amide derivative The present invention provides compounds of formula I, ##STR1## wherein X is hydrogen, chlorine or bromine and Y is hydrogen or bromine, with the proviso that when X is chlorine Y is hydrogen, Z is carbonyl or sulphonyl, R1 is alkyl of 1 to 4 c... | 02/03/1981 |
| 4202976 | Selenium-75 labelled derivatives of folates Novel selenium-75 derivatives of folates, which are useful in competitive radio assay of folates, have the general formula: ##STR1## where a dotted bond line indicates that the bond may be single or double, and where X is H or --CH3, m is ... | 05/13/1980 |
| 4028465 | Assay method for serum folate Serum folate assay procedure by competitive binding in which serum folate is stabilized while being freed from serum folate proteins in the presence of a dithiopolyol, preferably a 1,4-dithiotetritol such as dithiothreitol. Subsequently in the procedure, ... | 06/07/1977 |
| 3983118 | Production of N5 -methyltetrahydrohomofolic acid and related reduced derivatives of homofolic acid The preparation of N5 -methyltetrahydrohomofolic acid and alkali metal salts thereof is from homofolic acid starting material (HFA) by catalytic reduction with platinum oxide in the dark under hydrogen at a slight overpressure to produce tetrah... | 09/28/1976 |
