Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7501512 | Chemical compounds This invention relates to newly identified inhibitors of kinases for treating various disorders. ... | 03/10/2009 |
| 7407964 | Caspase inhibitors and uses thereof This invention provides novel caspase inhibitors of formula I: wherein R1 is hydrogen, CHN2, R, or —CH2Y; R is an aliphatic group, an aryl group, an aralkyl group, a heterocyclyl group, or... | 08/05/2008 |
| 7285559 | Imidazo-substituted compounds as p38 kinase inhibitors The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, m... | 10/23/2007 |
| 7256198 | Pyrimidoindolones and methods for using same Novel pyrimidoindolone compounds are disclosed. Methods of using the pyrimidoindolone compounds and compositions containing the compounds in the treatment and/or prevention of disease and other conditions related to inflammation, neurodegeneration, osteoarthritis an... | 08/14/2007 |
| 7196094 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives This invention comprises the novel compounds of formula (I) wherein r, t, Y1—Y2, R1, R2, R3, R4, R5, R6 and R7 ... | 03/27/2007 |
| 7173040 | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives This invention comprises the compounds of formula (I): wherein r, s, t, Y1–Y2, R1, R2, R3, R4, R5, R6 and R7 ha... | 02/06/2007 |
| 7105663 | Derivatives of pyrimido[6,1-a]isoquinolin-4-one Compounds of general formula (I) wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; R5 represents a hydrogen atom or a C1-3 alkyl, C2-3 alkenyl or C2-3... | 09/12/2006 |
| 7067519 | 7,8,9,10-tetrahydro-6-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2-pyrrolo[2,1-]-quinazolinone derivatives The invention relates to novel 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns re... | 06/27/2006 |
| 6893650 | N2-phenylamidine derivatives The invention provides fungicidal compounds of formula (I) and salts thereof wherein: R1 is alkyl, alkenyl, alkynyl, carbocyclyl or heterocyclyl, each of which may be substituted, or hydrogen; R2 and R3, which may be the same or diff... | 05/17/2005 |
| 6875771 | Pyridopyrimidine derivatives as 5-HT6 antagonists Novel pyridopyrimidine derivatives which have a binding affinity for the human 5-HT6 receptor and, therefore, are useful in treating disorders responsive to antagonism of the 5-HT6 receptor such as psychosis, schizophrenia, manic depression, de... | 04/05/2005 |
| 6858613 | Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to trea... | 02/22/2005 |
| 6844089 | Organic red electro-luminescent device and dopant The invention relates to an electroluminescent device, in which the luminescent layer contains a luminescent compound and a compound of the general formula I as doping agent, wherein B is an unsaturated carbocyclic or heterocyclic 4-8-link ring, which can also conta... | 01/18/2005 |
| 6831074 | Pharmaceutically active compounds The present invention provides a compound of formula (I): where Q is a group of formula: These compounds inhibit cyclic guanosine 3′,5′-monophosphate phosphodiesteras... | 12/14/2004 |
| 6794391 | Derivatives of pyrimido[6.1-a]isoquinolin-4-one The invention provides compounds or salts thereof of the general formula (I): wherein each of R1 and R2 independently represents a C1-6 alkyl or C2-7 acyl group; X represents O... | 09/21/2004 |
| 6774236 | Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives The invention relates to a process and intermediates for the preparation of enantiomerically pure cycloalkanoindolecarboxylic acids and azaindolecarboxylic acids and pyrimido[1,2a]indolecarboxylic acids and their activated derivatives, characterized in that the toly... | 08/10/2004 |
| 6680312 | Sulfonamide derivatives, their production and use The present invention is to provide a compound or a salt thereof represented by the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally su... | 01/20/2004 |
| 6624159 | Heterocycle carboxamides as antiviral agents The present invention provides a compound of formula I ##STR1## which is useful as antiviral agents, in particular, as agents against viruses of the herpes family.... | 09/23/2003 |
| 6538000 | Tricyclic dihydropyrimidine potassium channel openers Compounds of formula (I) ##STR1## are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.... | 03/25/2003 |
| 6492364 | Triazolo and derivatives as chemokine inhibitors Novel triazolo derivatives represented by the following formula and pharmaceutically acceptable salts thereof, as well as chemokine inhibitors containing the same as an effective component. These are useful as therapeutic agents for allergic diseases such... | 12/10/2002 |
| 6448255 | Imidazo-isoquinolin-5-one derivatives, pyrimido-isoquinolin-6-one derivatives and imidazo-naphthyridin-5-one derivatives Antiatherosclerotic compounds are provided which have the following structure: ##STR1## wherein: R is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, heteroaryl, or aryl or heteroaryl substituted with one or more members of the group consisting of alk... | 09/10/2002 |
| 6337331 | Triazolo-pyrimidine as ligands for GABA receptors Substituted or 6,7-ring fused 1,2,3-triazolo[1,5-]-pyrimidine derivatives are selective ligands for GABAA receptors useful in the treatment of disorders of the central nervous system, including anxiety and convulsions.... | 01/08/2002 |
| 6288070 | Triazolopurine derivatives, medicinal composition containing the derivatives, adenosine A3 receptor compatibilizing agent, and asthmatic remedy Disclosed is a triazolopurine derivative represented by the general formula: ##STR1## wherein R1 and R2 represent the same groups as those described in the specification; and A represents a group: ##STR2## wherein R3 ... | 09/11/2001 |
| 6201116 | Halide indicators The invention provides methods and compositions for measuring ion concentration inside a cell by measuring fluorescence of a compound of the general formula I. In particular embodiments, the measured ion is halide, particularly iodide, the cell contains a... | 03/13/2001 |
| 6197778 | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NOn -PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The ... | 03/06/2001 |
| 6147080 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The compounds are of the class of pyrido [1,2-c] pyrimidin-3-one or 1,2-dihydro-pyrido [1,2-c] py... | 11/14/2000 |
| 6114341 | Pyrimido[1,2-a]indoles The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medica... | 09/05/2000 |
| 6057315 | Antibacterial agents Described are antibacterial agents of formula (I): X is O, S or N--R.sub.8 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.8 are independently H, straight or branched alkyl of 1-6 carbons, cycloalkyl of 3-6 carbons, alkenyl or alkynyl of from 2 to 6 atoms, R hetero... | 05/02/2000 |
| 6057329 | Fused polycyclic 2-aminopyrimidine derivatives Fused polycyclic 2-aminopyrimidines of formula (1): ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optiona... | 05/02/2000 |
| 6028195 | Piperazine derivatives and process for the preparation thereof The present invention relates to novel compound having strong antimumor activities of the general formula(I) ##STR1## wherein R1 and R2 are independently hydrogen, substituted or unsubstituted C1 -C8 alkyl,... | 02/22/2000 |
| 5994366 | Tetrahydroimidazo[2,1-A]isoquinoline derivatives The present invention relates to certain tetrahydroimidazo[2,1-a]isoquinoline derivatives according to formula I wherein X is a group (A) or (B) ##STR1## R1, R2 and R3, which may be the same or different, each re... | 11/30/1999 |
| 5952498 | Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido 1,2a! indolcarboxcyclic acids and their activated derivatives The invention relates to a process and intermediates for the preparation of enantiomerically pure cycloalkanoindolecarboxylic acids and azaindolecarboxylic acids and pyrimido1,2a!indolecarboxylic acids and their activated derivatives, characterized in t... | 09/14/1999 |
| 5922763 | Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts the... | 07/13/1999 |
| 5914327 | Biaryl-pyridoquinazolinone derivatives as anti-cancer agents This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4; (B) R1 and R2 are the same or different and selected from the group consisting of H, (C1 -C3)alkyl, --CH2 CH2 | 06/22/1999 |
| 5908840 | Hetero-biaryl-pyridoquinazolinone derivatives as anti-cancer agents This invention provides a compound having the formula: ##STR1## wherein: (A) n=2-4; (B) R1 and R2 are the same or different and selected from the group consisting of H, (C1 -C3) alkyl, --CH2 CH2 | 06/01/1999 |
| 5854237 | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists Tricyclic diazepines of the formula: ##STR1## wherein A, B, D, E, F, Y and Z are defined in the specification which compounds have vasopressin and oxytocin antagonist activity.... | 12/29/1998 |
| 5852014 | Condensed indole derivatives as 5HT4 -receptor antagonists Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders.... | 12/22/1998 |
| 5846969 | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives A sulfonamide derivative or a sulfonic ester derivative represented by the following general formula (I): ##STR1## {G represents an aromatic 5- or 6-membered ring; L represents O or --N(R1)-- (R1 represents hydrogen or lower alk... | 12/08/1998 |
| 5750532 | Pharmaceutically active compounds The disclosed invention is compounds represented by the formula ##STR1## and pharmacetically acceptable acid salts thereof, wherein each Z is independently tetiary butyl, phenyl, naphthyl or adamantyl; substituted phenyl, wherein the substituents are... | 05/12/1998 |
| 5705498 | Piperidine derivatives as 5-HT4 receptor antagonists Compounds of formula (I): ##STR1## wherein Xg is O, S, SO, SO2, CH2, CH, N or NR wherein R is hydrogen or C1-6 alkyl; A is a saturated or unsaturated polymethylene chain of 2-4 carbon atoms; R1g | 01/06/1998 |
| 5668140 | Substituted 4-aminopyrimidines, processes for their preparation, and their use as pesticides Substituted 4-aminopyrimidines, processes for their preparation, and their use as pesticides The invention relates to substituted 4-aminopyrimidines of the formula ##STR1## in which: R1 is hydrogen, halogen, alkyl or cycloalkyl, R2 i... | 09/16/1997 |
