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| Number | Title | Issue Date |
| 7888505 | 6,7-dihydrobenzimidazo[1,2-c]quinazolin-6-one carboxylic acids, their esters, and methods of synthesis thereof The present invention relates to a 6,7-dihydrobenzimidazo[1,2-c]quinazolin-6-one carboxylic acid and its esters of the general structural formula (I), and provides a method for their synthesis (I) where R and each R′ are selected independently from the list compri... | 02/15/2011 |
| 7838674 | Tetracyclic lactame derivatives The present invention describes tetracyclic compounds of formula (IA) or (IB), wherein the symbols R, X, A, Y, R2, R3 and D are as defined in the specification, their use in the treatment of certain diseases, e.g. depending... | 11/23/2010 |
| 7834180 | Methods of preparing quinolone analogs Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, | 11/16/2010 |
| 7816524 | Methods of preparing quinolone analogs Compounds having formula 1 are produced by contacting a compound having formula(6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, | 10/19/2010 |
| 7763725 | Pyrimido-benzimidazole derivatives and the use thereof in the form of agonists and antagonists of melanocortin receptors The invention relates to novel pyrimido-benzimidazole derivatives. Said products exhibit a good affinity for certain melanocortin receptor sub-types, in particular MC4 receptors. Said products represent a particular interest for treating pathological disorders and d... | 07/27/2010 |
| 7294738 | Phosphorous containing steroid mimics The present invention discloses novel steroid mimics wherein a tri- or tetravalent phosphorous atom is isosterically substituted at any one of the seventeen positions occupied by the carbon atom in the steroidal skeleton, and wherein each adjacent position to the ph... | 11/13/2007 |
| 7256196 | Purine cytokine inhibitors The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions c... | 08/14/2007 |
| 7253292 | Synthesis of cyclopentadiene derivatives A process for preparing cyclopentadiene derivatives comprising the steps of: a) coupling a five membered heterocycle ring with a five or six membered heterocycle ring; b) reacting the obtained compound with a carbonilating system: c) reducing the obtained compound. | 08/07/2007 |
| 7253177 | Synthesis and antimalarial activity of pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and | 08/07/2007 |
| 7195879 | Method for identifying modulators of NAion channels The present invention provides methods to manipulate differentiation of a neuroblastoma cell line (IMR-32) such that predominant Nav expression is either Nav1.3 in IMR-32 cells exposed to retinoic acid or Nav1.7 in cells grown under ... | 03/27/2007 |
| 7176310 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents This invention is directed to compound of the following formula (I): wherein R1, R2, R3 and R4 are as described herein. These compounds and pharmaceutical compositions ... | 02/13/2007 |
| 6969719 | Polycyclic guanine phosphodiesterase V inhibitors A polycyclic guanine phosphodiesterase V inhibitor having the formula (I.1) or (II.1), with the variables defined herein, which is useful for treating sexual dysfunction and other physiological disorders: A representativ... | 11/29/2005 |
| 6960585 | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders, wherein X, Y1, Y2, and R | 11/01/2005 |
| 6951942 | Glucocorticoid-selective anti-inflammatory agents Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also di... | 10/04/2005 |
| 6921761 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R1 | 07/26/2005 |
| 6894055 | Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase Compounds of formula 1 are effective modulators of PI3 kinase: wherein X is CR9R10, O, NR11 (where R9 and R10 are each independently H, lo... | 05/17/2005 |
| 6872743 | sPLA2 inhibitors A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 medi... | 03/29/2005 |
| 6750214 | Quinoline and quinazoline compounds useful in therapy The invention provides compounds of formula (I), wherein R1 represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R2 represents H or C1-6 alkoxy optional... | 06/15/2004 |
| 6747039 | Aza-benzothiopyranoindazoles with antitumor activity The present invention relates to a group of aza-anthrapyrazole compounds having antitumor activity, and processes for their preparation. Compositions containing the aza-anthrapyrazole compounds and methods of treating tumors and cancer in mammals with the compounds ... | 06/08/2004 |
| 6673798 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same A purified tyrphostin of a general formula: ##STR1## wherein, for Compound I, R6 is either at position 6 or at position 7, or, for Compound II, R6 is either at position 6 or at position 8.... | 01/06/2004 |
| 6667405 | Methine compound and silver halide photographic material containing the same Disclosed is a compound represented by the following formula (I): ##STR1## wherein Z1 represents an atomic group necessary to form a 5- or 6-membered nitrogen-containing heterocyclic ring; Z2 represents an atomic group necessary to f... | 12/23/2003 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6562968 | Method of purifying tetrodotoxin The present invention relates to a new process of purifying tetrodotoxin using high performance liquid chromatograph technology.... | 05/13/2003 |
| 6552191 | Method of extracting tetrodotoxin The present invention relates to a new process of extracting tetrodotoxin from the tissues of an organism. The invention provides increased yield of tetrodotoxin from animal tissues. In the invention, a lixiviated solution is obtained by soaking the tissu... | 04/22/2003 |
| 6478966 | System for extracting tetrodotoxin The invention relates to a system for extracting toxins from biological tissues. The system comprises a lixiviator, an ion-exchange column, a diatomaceous silica-active carbon column, and a vacuum concentrator. Twenty to one hundred kilograms of raw mater... | 11/12/2002 |
| 6444808 | Methods of making cross-bridged macropolycycles Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.... | 09/03/2002 |
| 6429311 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis... | 08/06/2002 |
| 6380193 | Fused tricyclic compounds, methods and compositions for inhibiting PARP activity A compound of formula I: ##STR1## or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof.... | 04/30/2002 |
| 6358954 | PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same An isometric enriched tyrphostin of a general formula: ##STR1## wherein, for Compound I, the tyrphostin is enriched either for R6 at position 6 or for R6 at position 7, or, for Compound II, the tyrphostin is enriched either for R | 03/19/2002 |
| 6355803 | Near infrared chemiluminescent acridinium compounds and uses thereof This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional groups to the acridinium nucleus, with coplanarity of the ... | 03/12/2002 |
| 6337331 | Triazolo-pyrimidine as ligands for GABA receptors Substituted or 6,7-ring fused 1,2,3-triazolo[1,5-]-pyrimidine derivatives are selective ligands for GABAA receptors useful in the treatment of disorders of the central nervous system, including anxiety and convulsions.... | 01/08/2002 |
| 6288094 | Polycyclic thiazol-2-ylidene amines, processes for their preparation and their use as medicaments The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, ##STR1## in which the radicals have the stated... | 09/11/2001 |
| 6281355 | Nitrogen-containing tetracyclic compounds A nitrogen-containing tetracyclic compound represented by the formula: ##STR1## wherein Y1 --Y2 --Y3 is N--C.dbd.N or a group represented by the formula: C.dbd.C--NR3 (wherein R3 is a hydrogen atom, a ... | 08/28/2001 |
| 6225464 | Methods of making cross-bridged macropolycycles Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.... | 05/01/2001 |
| 6218400 | Treatment method using a cGMP-Specific PDE inhibitor A compound of formula ##STR1## and salts and solvates thereof, wherein R0, R1, and R2 are defined in the specification. A compound of the present invention is a potent and selective inhibitor of cGMP-specific PDE and has u... | 04/17/2001 |
| 6184377 | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof The present invention is directed to certain N-amino- and N-hydroxy-quinazolinone compounds and synthetic methods for synthesis thereof, which compounds may find use in combinatorial libraries. More specifically, the invention is directed to the synthesis... | 02/06/2001 |
| 6159996 | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals Polycyclic thiazolidin-2-ylidene amines and their physiologically tolerable salts and physiologically functional derivatives of the formula I ##STR1## in which the radicals have the meanings indicated, and their physiologically tolerable salts and a ... | 12/12/2000 |
| 6107304 | Thieno[2,3-b]pyrazolo[3,4-d]pyridine-3-ones to enhance erythropoiesis Invented are substituted thieno (2,3-b)pyrazolo(3,4-d)pyridin-3-ones, pharmaceutical compositions containing these compounds, and methods of using these compounds to enhance erythropoiesis. Also invented are intermediates and processess used in preparing ... | 08/22/2000 |
| 6057329 | Fused polycyclic 2-aminopyrimidine derivatives Fused polycyclic 2-aminopyrimidines of formula (1): ##STR1## wherein Ar is an optionally substituted aromatic or heteroaromatic group; X is a carbon or nitrogen atom; Y is a carbon or nitrogen atom; Z is a linker group; A together with X and Y forms an optiona... | 05/02/2000 |
| 6022497 | Photochromic six-membered heterocyclic-fused naphthopyrans Described are novel photochromic six-membered heterocyclic-fused naphthopyran compounds, examples of which are naphthopyran compounds having a substituted or unsubstituted six-membered heterocyclic group fused to one side of the naphtho portion of the nap... | 02/08/2000 |
