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| Number | Title | Issue Date |
| 8153789 | Imidazo[1,2-b]pyridazines, processes, uses, intermediates and compositions The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases associate... | 04/10/2012 |
| 8148524 | Process for producing sulfonyl chloride compound A process for producing a sulfonyl chloride compound comprising: (A) a step comprising reacting a pyridazine compound represented by the formula (1): wherein R1 represents a hydrogen atom, a halogen atom, ... | 04/03/2012 |
| 8053574 | Organic compounds Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptabl... | 11/08/2011 |
| 7812158 | Coupling agents for peptide synthesis The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis. ... | 10/12/2010 |
| 7705147 | Indole derivatives as selective androgen receptor modulators (SARMS) The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ... | 04/27/2010 |
| 7465730 | Treatment of neuropathic pain with 6-pyrrolo[3,4-]pyridazine compounds 6H-pyrrolo[3,4-d]pyridazine compounds and methods of their use of as ligands of voltage gated calcium channels (VGCC), useful in the treatment of neuropathic pain, and psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, an... | 12/16/2008 |
| 7432266 | Phosphodiesterase 4 inhibitors Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs. ... | 10/07/2008 |
| 7432262 | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions The invention relates to substituted imidazopyridazinediones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereo... | 10/07/2008 |
| 7429581 | Pyrazole-derivatives as factor Xa inhibitors The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is... | 09/30/2008 |
| 7414131 | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in ma... | 08/19/2008 |
| 7410967 | Pyridodiazines as plant fungicides Fungicidal compounds of general formula (1) wherein R, R1, R2, W, X, Y and Z are as defined in the specification ... | 08/12/2008 |
| 7399764 | Inhibitors of Akt activity The present invention is directed to compounds which contain a five-membered heterocyclic ring fused to a substituted pyrazine moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic composit... | 07/15/2008 |
| 7393847 | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions The invention relates to substituted imidazopyridazinediones of general formula wherein R1 and R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and ... | 07/01/2008 |
| 7390808 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ... | 06/24/2008 |
| 7378418 | Azabicyclic heterocycles as cannabinoid receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 05/27/2008 |
| 7371752 | Aryl fused substituted 4-oxy-pyridines Disclosed are compounds of the formula: wherein X, Q, W and are as defined herein. These compounds are agonists, antagonists or inverse agonists for GABAA brain recepto... | 05/13/2008 |
| 7365072 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 04/29/2008 |
| 7361766 | Bicyclic heterocycles as cannabinoid receptor modulators The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to... | 04/22/2008 |
| 7351826 | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds The invention provides compounds of Formula (I) that bind to GABAA receptors. In the above formula, variables are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly... | 04/01/2008 |
| 7348326 | Heteroaryl fused aminoalkyl imidazole derivatives: selective modulators of GABAreceptors Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein the A, B, C, D, X, R1, R2, R3, R4, R5, and R6, are... | 03/25/2008 |
| 7329659 | Substituted-1-phthalazinamines as vr-1 antagonists The present invention provides a compound of formula (I): in which Ar and R1 are phenyl or a heteroaromatic group, R2 is generally hydrogen, R3 is hydrogen or alkyl and X, Y and Z are generally CH or N as VR-1 antagonists; or a pharm... | 02/12/2008 |
| 7307165 | Process for producting imidazo[1,2-b]pyridazine derivative A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): ... | 12/11/2007 |
| 7307164 | β-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes The present invention is directed to compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme i... | 12/11/2007 |
| 7294625 | Pyrazole compounds The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, ... | 11/13/2007 |
| 7279473 | Pyrazolopyridazine derivatives Fused pyradazine derivatives which are usefule as CDK inhibitors are described herein. The described invention alos includes methods of making such fused pyradazine derivatives as wells as methods of using the same in the treatment of hyperproliferative diseases. | 10/09/2007 |
| 7271168 | Piperazine derivatives having SST1 antagonistic activity The invention provides compounds of formula (1) wherein X, R1 and R2 are as defined in the specification, their, preparation and to their use in treating, e.g., depression, anxiety an... | 09/18/2007 |
| 7268136 | Compositions useful as inhibitors of protein kinases The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of PIM-... | 09/11/2007 |
| 7262195 | Compounds useful as motilin agonists and method Compounds are provided which are useful in treating disorders of gastrointestinal motility and which have the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomer... | 08/28/2007 |
| 7232826 | Tyrosine kinase inhibitors The present invention provides compounds of Formula I or II that are useful as anti-cancer agents and other diseases that can be treated by inhibiting tyrosine kinase enzymes ... | 06/19/2007 |
| 7232823 | Cannabinoid receptor ligands and uses thereof Compounds of Formula (I) or (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described herein ... | 06/19/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7226922 | Imidazo[1,2-b]pyridazine analogues as anxiolytics and cognition enhancers The present invention provides a compound of formula I: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; | 06/05/2007 |
| 7217711 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomer... | 05/15/2007 |
| 7211572 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt th... | 05/01/2007 |
| 7205299 | Indole derivatives having an apoptosis-inducing effect The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma. ... | 04/17/2007 |
| 7196085 | Phthalazinone derivatives A compound of formula: or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is ... | 03/27/2007 |
| 7192968 | Ethylenediamine derivatives The invention relates a compound represented by the formula (1): Q1-Q2-C(═O)—N(R1)-Q3-N(R2)-T1-Q4 (1) wherein R1 and R2 represent H... | 03/20/2007 |
| 7189715 | Compositions comprising zopiclone derivatives and methods of making and using the same The invention is directed to racemic and stereomerically pure compounds of Formula 3: and to pharmaceutical compositions comprising them, methods of their use, and methods of their preparation. ... | 03/13/2007 |
| 7189721 | Bicyclic protein kinase inhibitors The present invention relates to novel 3-hetero-arylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase rel... | 03/13/2007 |
| 7186841 | Antiinflammation agents Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or ... | 03/06/2007 |
