Class 544/232 - Phosphorus attached directly or indirectly to a 1,2-diazine ring by nonionic bonding

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein phosphorus is attached directly or indirectly
No. of patents: 152
Last issue date: 09/23/2008

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Number	Title	Issue Date
7427624	Purine nucleoside phosphorylase inhibitory phosphonate compounds The invention is related to phosphorus substituted purine nucleoside phosphorylase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates usef...	09/23/2008
7414056	Pyrazole-amide compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6	08/19/2008
7410956	Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ...	08/12/2008
7390810	Pyrazole-amine compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6	06/24/2008
7358250	Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of t...	04/15/2008
7312326	Fluorescent labeled nucleotide derivatives Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cy...	12/25/2007
7312219	Heteroaromatic inhibitors of fructose 1,6-bisphosphatase Novel FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose. ...	12/25/2007
7288542	Non-nucleoside reverse transcriptase inhibitors The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human ...	10/30/2007
7253169	Aza compounds, pharmaceutical compositions and methods of use The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities. ...	08/07/2007
7186797	Polypeptide conjugates with extended circulating half-lives The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit ...	03/06/2007
7115591	Prostaglandin endoperoxide H synthase biosynthesis inhibitors The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2), COX-2 is the inducible isofo...	10/03/2006
7001895	Prostaglandin endoperoxide H synthase biosynthesis inhibitors The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform ass...	02/21/2006
6995261	4-pyridazinecarboxamides and esters as interleukin-1β converting enzyme inhibitors Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1 is a halogen, or an oxygen linked leaving group including an aromatic et...	02/07/2006
6919323	Pyridazinone inhibitors of fatty acid binding protein and method aP2 inhibiting compounds are provided having the formula wherein A, X, R and Z are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employi...	07/19/2005
6833364	Substituted pyrazole derivatives The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R1, R2, R3, A, X and Y are each as defined, and to processes...	12/21/2004
6812231	Benzamidine derivative Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating ...	11/02/2004
6774130	Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 (“IL-12”) intrace...	08/10/2004
6716828	Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage This invention relates to compounds, pharmaceutical compositions, and methods for the treatment or prevention of neural or cardiovascular tissue damage related to cerebral ischemia and reperfusion injury in an animal by administering Poly(ADP-ribose) polymerase (“...	04/06/2004
6706698	α-Substituted β-aminoethyl phosphonate derivatives The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and ver...	03/16/2004
6673781	Tricyclic compounds having sPLA2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): ##STR1## wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocycl...	01/06/2004
6555663	Prodrugs for selective drug delivery A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a recept...	04/29/2003
6525053	Prostaglandin endoperoxide H synthase biosynthesis inhibitors The present invention describes pyridazione compounds having the formula (I), which are cyclooxygenase (COX) inhibitors The compounds are selective inhibitors of cyclooxygenase-2-(COX-2), which is the inducible isoform associated with inflammation, as opp...	02/25/2003
6489476	Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase FBPase inhibitors of the formula I and X ##STR1## are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage....	12/03/2002
6410538	Benzamidine derivatives Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing o...	06/25/2002
6307047	Prostaglandin endoperoxide H synthase biosynthesis inhibitors The present invention describes pyridazinone compounds of formula I ##STR1## which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, a...	10/23/2001
6291425	Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP....	09/18/2001
6288123	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	09/11/2001
6194576	Process for preparing antiviral 2-phosponate nucleotide analogs Nucleotide analogues having the general formula (I) and pharmaceutically acceptable derivatives: ##STR1## wherein n is 0 or an integer; X is O or S, CH2, CH-halogen, CH--N3, or C.dbd.CH2 ; Q and U are independently selected fro...	02/27/2001
6174924	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	01/16/2001
6143791	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	11/07/2000
6127371	Endothelin receptor antagonists Novel indane and indene derivatives are described which are endothelin receptor antagonists....	10/03/2000
6121251	Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides Compounds with fungicidal and insecticidal properties having formula I ##STR1## wherein W is ##STR2## n is 0 or 1; Y is O, S, NR1, or R6 ; the ring bond containing R4 and R5 is a single or double bond; X is...	09/19/2000
6069248	Process for the synthesis of triazolopyridazine compounds The present invention provides a process for the synthesis of triazolopyridazine based compounds represented by Formula A: ##STR1## These compounds have utility as angiotensin related antihypertensive agents....	05/30/2000
6057304	Quinoxaline-phosphonic acid derivatives The disclosure relates to quinoxaline derivatives of Formula I ##STR1## wherein R1, R4, R5, R6, R7 and R8 are as defined in the disclosure, as well as their production and use in medic...	05/02/2000
6002003	Cyanine dye activating group with improved coupling selectivity Activating groups for cyanine dyes used to label chain terminators in nucleotide sequencing, based on N-hydroxyphthalimide, are disclosed. From these activating groups, activated dyes of the present Invention are prepared which react with the derivitized ...	12/14/1999
5962437	Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus and herpes viruses, is disclosed. The method comprising administering to a subject in need of such treatment an infection-combating amount of a phospholipid or phospholipid ...	10/05/1999
5886177	Phosphate linked oligomers Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosphoramidate linkage...	03/23/1999
5874577	Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof Unprotected adenine, 6-chloropurine, 2,6-diaminopurine, and 2-amino-6-chloropurine have been directly coupled with 2-(diethoxyphosphonomethoxy)ethanol under a disclosed method to provide acyclic phosphonate nucleotide analogues which are intermediates for...	02/23/1999
5773592	Pro drugs for selective drug delivery A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a recept...	06/30/1998
5750525	Quinoxalinedione derivatives, their production and use in pharmaceutical agents Compounds of formula I are described ##STR1## in which R1, R5, R6, R7 and R8 have the meanings mentioned in the application as well as their production and use in pharmaceutical agents....	05/12/1998

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Class 544/232 - Phosphorus attached directly or indirectly to a 1,2-diazine ring by nonionic bonding