Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 7547780 | Dihydropteridione intermediate compounds Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the is... | 06/16/2009 |
| 7429598 | Spirocondensed quinazolinones and their use as phosphodiesterase inhibitors The invention relates to compounds of formula (I) wherein R1, R2 and m are as defined in the description, their use as medicament, pharmaceutical compositions containing them and a process for their pr... | 09/30/2008 |
| 7378411 | Substituted thienopyrimidinones as a mitotic kinesin inhibitor The present invention relates to thienopyrimidinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which ... | 05/27/2008 |
| 7371753 | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions Disclosed are new dihydropteridinones of general formula (I) wherein the groups R1 to R5, Ra to Rc, W, Q1 and Q2 have the meanings given in the claims and sp... | 05/13/2008 |
| 7361758 | Crystals of triazaspiro[5.5]undecane derivative The present invention relates to a new crystal of triazaspiro[5.5]undecane derivatives. The crystal of a non-solvate of (3R)-1-butyl-2,5-dioxo-3-[(1R)-1-hydroxy-1-cyclohexylmethyl]-9-[4-(4-carboxyphenyloxy)phenylmethyl]-1,4,9-triazaspiro[5.5]undecane hydrochloride h... | 04/22/2008 |
| 7338954 | Compounds useful as motilin agonists and method A method is provided for treating disorders of gastrointestinal motility which include the steps of administering to a patient in need of treatment of a compound having the structure or a pharmaceutically acceptable salt th... | 03/04/2008 |
| 7332491 | Dihydropteridione derivatives, process for their manufacture and their use as medicament Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specificat... | 02/19/2008 |
| 7294632 | Substituted 8′-pyridinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a]pyrimidin-6-one and 8′-pyrimidinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a]pyrimidin-6-one derivatives The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also... | 11/13/2007 |
| 7294631 | Substituted 8′-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-]pyrimidin-6-one derivatives The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention rela... | 11/13/2007 |
| 7268128 | 1,3,5-trisubstituted-5-phenyl and 5-pyridyl pyrazolopyrimidinone derivatives having PDE7 inhibiting action Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): where the symbols are as disclosed in the specification, are provided as desired compounds. These compounds selectively in... | 09/11/2007 |
| 7262193 | Triazaspiro[5.5]undecane derivative and pharmaceutical composition comprising the same as active ingredient Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R1 is formula (II) or formula (III); R | 08/28/2007 |
| 7241889 | 6-formyl-tetrahydropteridines, process for their manufacture and use thereof as medicaments Disclosed are 6-formyl-tetrahydropteridines of the formula (I) wherein the groups R1 to R6 have the meanings given in the claims and specification, the isomers thereof, methods of preparing ... | 07/10/2007 |
| 7238807 | Process for the manufacture of fused piperazin-2-one derivatives Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I) wherein the groups R1 to R5, A1 and A2 have the meanings given i... | 07/03/2007 |
| 7235538 | Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R1, R2, R3 | 06/26/2007 |
| 7214676 | Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are a... | 05/08/2007 |
| 7176313 | Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient An anti acid-fast bacterial agent containing, as an active ingredient, a pyridonecarboxylic acid derivative represented by the following general formula (1), a salt thereof, or a hydrate thereof, which shows excellent antibacterial activity against Mycobacterium ... | 02/13/2007 |
| 7129245 | Aromatic amides This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.... | 10/31/2006 |
| 7122662 | Tricyclic compound having spiro union This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which e... | 10/17/2006 |
| 7109243 | Inhibitors of cathepsin S The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present inven... | 09/19/2006 |
| 7094368 | Pyrano-quinolines, pyrano-quinolinones, combinations thereof, photochromic compositions and articles Described are compositions of at least one material represented by a pyrano[3,2-c]quinoline structure, a pyrano[3,2-c]quinolinone structure or mixtures thereof. The pyrano[3,2-c]quinoline structure is characterized by having a nitrogen atom at the 6-position ring at... | 08/22/2006 |
| 7067501 | Aryloxyphenyl and arylsulfanylphenyl derivatives The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors. ... | 06/27/2006 |
| 7053090 | Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R1 is formula (II) or formula (III); R | 05/30/2006 |
| 7008555 | Epoxy resin curing agents and epoxy resin compositions A curing agent for epoxy agent having N-phenyl-p-phenylenediamine(4-aminodiphenylamine). An epoxy resin combination having a main agent and a curing agent. The main agent has an epoxy resin. The curing agent has a N-phenyl-p-phenylenediamine(4-aminodiphenylamine). | 03/07/2006 |
| 6967201 | Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1... | 11/22/2005 |
| 6943171 | Polycyclic guanine derivative phosphodiesterase V inhibitors A compound having the formula (Ia) or (b), salt or solvate thereof, with the variables as defined herein, which can inhibit selectively phosphodiesterase V and can be useful for treating sexual dysfunction and other physiological disorders, symptoms and diseases: | 09/13/2005 |
| 6919349 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by th... | 07/19/2005 |
| 6916807 | Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as ... | 07/12/2005 |
| 6911452 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease conditio... | 06/28/2005 |
| 6900201 | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G... | 05/31/2005 |
| 6894048 | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors Substituted dihydrophthalazine sulfur containing compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with excessive activation of the non-NM... | 05/17/2005 |
| 6861422 | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, proces... | 03/01/2005 |
| 6841671 | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said “A” is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutica... | 01/11/2005 |
| 6740636 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective amount of a non-peptide CCR1 receptor antagonist and a sub-nephrotoxic ... | 05/25/2004 |
| 6703390 | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors Substituted dihydrophthalazine sulfur containing compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with excessive activation of... | 03/09/2004 |
| 6677451 | Preparation of sterically hindered amine ethers A new process is described for the preparation of a compound of the formula I ##STR1## wherein R1, R2, R3 and R4, independently of each other, are C1 -C8 alkyl or C1 -C5... | 01/13/2004 |
| 6677336 | Substituted piperazine compounds Novel compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subse... | 01/13/2004 |
| 6649622 | Tetrahydropyrimidone inhibitors of fatty acid binding protein and method aP2 inhibiting compounds are provided having the formula ##STR1## wherein A, B, X, and Y are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, employing such aP2 inhibitor or a combination ... | 11/18/2003 |
| 6534506 | Inhibitors of prenyl-protein transferase The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds... | 03/18/2003 |
| 6509346 | Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ##STR1## and ... | 01/21/2003 |
| 6503926 | Chemokine receptor antagonists and methods of use therefor Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: ##STR1## and ... | 01/07/2003 |
