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| Number | Title | Issue Date |
| 7439356 | Substituted indan derivatives The present invention relates to intermediates of the formula useful in the preparation of piperazinyl-substituted indan derivatives, wherein Y is CONR2 wherein R2 is H or C1-C | 10/21/2008 |
| 7300934 | Benzamide nitriles Compounds of the formula (I) wherein m, n, A, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds an... | 11/27/2007 |
| 7074640 | Method of making barrier layers The present invention involves a low-temperature, photoresist-free method of fabricating a barrier layer on a flexible substrate. An embodiment involves the conversion of a precursor into a top-surface imaging layer during a direct patterning step. Preferred precurs... | 07/11/2006 |
| 7067346 | Titanium carboxylate films for use in semiconductor processing The present invention involves the formation of titanium carbonate films that exhibit improved hydrolytic stability and photosensitivity. Such films can be used in semiconductor processing to deposit titanium and titanium oxide layers on a substrate and to form patt... | 06/27/2006 |
| 6982263 | Nitriles useful as reversible inhibitors of cysteine proteases Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions ex... | 01/03/2006 |
| 6956132 | Process for producing 2-phenylacetophenone derivatives and precursors therefor A process for producing 2-phenylacetophenone derivatives represented by the formula (I): (wherein X is an alkyl group or a haloalkyl group, and Y is a hydrogen atom, a halogen atom or an alkyl group which may be substi... | 10/18/2005 |
| 6927218 | Aryl N-cyanoguanidines and methods related thereto Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The ... | 08/09/2005 |
| 6903092 | Naphthamide neurokinin antagonists for use as medicaments Compounds having the general formula wherein R1, R2, R3, R4, R5, X1 and X2 are as defined in the specification, methods of using such compoun... | 06/07/2005 |
| 6878706 | Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B... | 04/12/2005 |
| 6821973 | Compounds A compound having the general formula R1R2N—CH2CH2—CHAr1—CH2—NR3—CO—R4 (I) and methods of using such compounds for the treatment of diseases ... | 11/23/2004 |
| 6747026 | NK-1 receptor active amine oxide prodrugs Compounds of the invention are amine oxide prodrugs showing activity on the NK1 receptor. ... | 06/08/2004 |
| 6720319 | Compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are... | 04/13/2004 |
| 6689882 | Process for the synthesis of morpholinylbenzenes A new improved process for synthesizing morpholinylbenzenes of the formula I by reacting morpholine of formula II with a substituted benzene of formula III, wherein morpholine is used as a reactant and as the only one solvent. ##STR1##... | 02/10/2004 |
| 6680317 | IL-8 receptor antagonists This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 01/20/2004 |
| 6593473 | Method of preparing granular N-alkyl-ammoniumacetonitrile salts Improved process for the preparation of granular N-alkylammoniumacetonitrile salts I R2 R3 N+ R1 --CR4 R5 --CN Y- (I) where R1 to R5 are hydrogen or organic radicals... | 07/15/2003 |
| 6593472 | NK-1 receptor active amine oxide prodrugs Compounds of the invention are amine oxide prodrugs showing activity on the NK1 receptor.... | 07/15/2003 |
| 6586432 | Neurokinin-1 receptor antagonists Compounds having the general formula R1 R2 N--CH2 CH2 --CHAr1 --CH2 --NR3 --CO--R4 (I) wherein R1, R2, R3, R4 and Ar are as defined... | 07/01/2003 |
| 6579328 | Transition-metal-catalyzed process for the preparation of sterically hindered N-substituted aryloxyamines Sterically hindered N-substituted aryloxyamines are prepared by the transition-metal-catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitroxyl radical. These compounds are useful as thermal and light stabilizers for a va... | 06/17/2003 |
| 6562965 | Convergent synthesis of -aryl-ଲ-ketonitriles The present invention relates to processes for the production of -aryl-ଲ-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) rece... | 05/13/2003 |
| 6562821 | Aryl-N-cyanoguanidines and methods related thereto Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and dia... | 05/13/2003 |
| 6498178 | Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibit... | 12/24/2002 |
| 6492362 | Compounds and compositions as cathepsin S inhibitors The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 12/10/2002 |
| 6479491 | Disubstituted morpholine, oxazepine or thiazepine derivatives, their preparation and their use as dopamine d4 receptor antagonists The present invention relates to compounds of formula (I), any of it enantiomers, or any mixture thereof, or a pharmaceutically acceptable acid addition salt thereof, wherein R1, R2, R3, R4, R11, R | 11/12/2002 |
| 6395897 | Nitrile compounds useful as reversible inhibitors of #9 cathepsin 5 Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. ##STR1##... | 05/28/2002 |
| 6335338 | Calcilytic compounds Novel calcilytic compounds are provided.... | 01/01/2002 |
| 6313117 | Succinate derivative compounds useful as cysteine protease inhibitors Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and metho... | 11/06/2001 |
| 6307087 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-fo... | 10/23/2001 |
| 6303652 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 10/16/2001 |
| 6294575 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 09/25/2001 |
| 6235218 | Process for preparing N-alkyl ammonium acetonitrile compounds A process is provided for the preparation of a compound having the structure of Formula I ##STR1## The process includes reacting a heterocyclic amine with a monoaldehyde or a dialdehyde in a pH range of from about 8 to 14 and then quaternizing the so... | 05/22/2001 |
| 6232309 | Insecticidal heterocyclic compounds Insecticidal heterocyclic compounds of the formula: ##STR1## wherein A represents a five-membered or six-membered heteroaryl group containing one to three hetero atoms selected from the group consisting of S, O and N, said heteroaryl group being unsubstit... | 05/15/2001 |
| 6221824 | Process for the production of compounded acetonitrile derivatives The storage stability of bleach-activating acetonitrile derivatives in solid detergent compositions was to be improved. This was essentially achieved by the use of compounded compounds corresponding to formula R1 R2 R3 N | 04/24/2001 |
| 6187944 | Acrylonitrile compounds, process for their production and pesticides containing them Acrylonitrile compounds having pesticidal activity of formula (I) and salts thereof. ##STR1## wherein Q is ##STR2## Y is .dbd.C(R4)-- or .dbd.N--, R1 is alkyl, haloalkyl, etc., each of R2 and R3 is halogen,... | 02/13/2001 |
| 6160010 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 12/12/2000 |
| 6020488 | Small molecule inhibition of RNA/ligand binding Disclosed is a method for the inhibition of binding of a ligand to an RNA, the inhibition being mediated by a small organic molecule that binds to the RNA, thereby inhibiting ligand binding. A preferred class of small organic molecules are compounds exemp... | 02/01/2000 |
| 6010994 | Liquid compositions containing N-alkyl ammonium acetonitrile salts The invention provides liquid cleaning or bleaching compositions containing compounds having the structure of Formula I ##STR1## wherein A is a saturated ring formed by five atoms in addition to the N1 atom, the five saturated ring atoms b... | 01/04/2000 |
| 5958289 | N-alkyl ammonium acetonitrile bleach activators Bleaching compositions are provided that comprise a nitrile containing compound that has the nitrile bonded to a quaternary nitrogen through a methylene unit (where one or both of the normal hydrogens can be substituted), and two of the quaternary nitroge... | 09/28/1999 |
| 5959104 | N-alkyl ammonium acetonitrile bleach activators Bleaching compositions are provided that comprise a nitrile containing compound that has the nitrile bonded to a quaternary nitrogen through a methylene unit (where one or both of the normal hydrogens can be substituted), and two of the quaternary nitroge... | 09/28/1999 |
| 5817877 | Metal-catalyzed amination of organic sulfonates to organic amines A process of preparing an organic amine having at least one unsaturated group, such as an arylamine, involving contacting an unsaturated organic sulfonate, such as an aryl sulfonate, with a reactant amine, such as an alkyl or aryl amine, in the presence o... | 10/06/1998 |
| 5789404 | 3-substituted 1-arylindole compounds 3-Substituted 1-arylindole compounds are provided having general formula (I) ##STR1## wherein Ar is an optionally substituted aryl group; X represents a divalent hydrocarbon group, methyleneoxy or -thioxo; R1 -R4 are hydrog... | 08/04/1998 |
