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| Number | Title | Issue Date |
| 7388008 | Lysine based compounds The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for exampl... | 06/17/2008 |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7341715 | Method and agents on the basis of 2-mercaptopropionic acid amides for durable hair forming and a method for producing same The preparation for permanently deforming hair has a pH of 6.5 to 9.5 and contains, as keratin-reducing agent, a 2-mercaptopropion-amide of the formula (I): in which R1 and R2, independently of one ano... | 03/11/2008 |
| 7279477 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of... | 10/09/2007 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7217832 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 05/15/2007 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7211696 | Antileishmanial dinitroaniline sulfanomides with activity against parasite tubulin Dinitroaniline compounds useful for the treatment of diseases caused by parasitic protozoa in subjects in need of such treatment. The compounds are particularly useful in the treatment of leishmaniasis. The compounds are preferably less cytotoxic to normal cells tha... | 05/01/2007 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 7183302 | Iminothiazolidinones as inhibitors of HCV replication Compounds having the structure of formula I are described wherein R, R′, R1, R2, and R3 are as defined in the specification. The compounds can inhibit hepatitis C virus (HCV) repl... | 02/27/2007 |
| 7183279 | Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 02/27/2007 |
| 7157454 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same The invention relates to compounds of formula: These compounds show affinity for the bradykinin receptors with selectivity towards the B1 receptors; they may be used for the preparation of medicinal pr... | 01/02/2007 |
| 7074786 | Histogranin-like peptides, processes for their preparation and uses thereof The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like antinociceptive, morphine potentiating and COX-2 induction modulating activitie... | 07/11/2006 |
| 7060718 | Arylsulfonanilide ureas The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particular... | 06/13/2006 |
| 7053212 | Acyclic amide and sulfonamide ligands for the estrogen receptor The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodrugs thereof, and the pharmaceutically acceptable salts of the... | 05/30/2006 |
| 6949567 | Compounds for the treatment of protozoal diseases The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C═O, C═S, C═NH, (C═O)2 or SO2; and to pro... | 09/27/2005 |
| 6924286 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 08/02/2005 |
| 6911477 | Muscarinic receptor agonists This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediat... | 06/28/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6887903 | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them The compounds of formula 1 wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN ... | 05/03/2005 |
| 6875765 | Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are described. In one embodiment, the compound is described by the generalized s... | 04/05/2005 |
| 6869951 | Method of changing conformation of a matrix metalloproteinase The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformat... | 03/22/2005 |
| 6849626 | Aza-amino acid derivatives (factor Xa inhibitors 15) The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formul... | 02/01/2005 |
| 6825184 | 1,4-Disubstituted benzo-fused urea compounds Disclosed are compounds of the formulas (I) & (II) shown below which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds. wherein G, X, A and Q are described herein. | 11/30/2004 |
| 6800659 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ... | 10/05/2004 |
| 6747148 | Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives, salts and... | 06/08/2004 |
| 6743790 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use The present invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5, R6, A, X, m and n have the meanings indicated in the claims. The... | 06/01/2004 |
| 6716844 | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl aipha-hydroxy hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid compound in an MM... | 04/06/2004 |
| 6689909 | Substituted N-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity A compound of formula (I) wherein: n is 1 or 2; R1 is chloro, fluoro, bromo, methyl or methoxy; R2 is as defined within; R3 is as defined within; and R4 is hydrogen or fluoro; or a pharmaceutically acceptable sa... | 02/10/2004 |
| 6667342 | Benzenesulfonamide-derivatives and their use as medicaments Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally oxidised to form the N... | 12/23/2003 |
| 6632816 | Aromatic derivatives as HIV aspartyl protease inhibitors The present invention provides HIV aspartyl protease inhibitors of the formula; ##STR1## and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, wherein R1 may b... | 10/14/2003 |
| 6608061 | Bisaryl compound and medicament for cancer treatment comprising the same A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1 --S--R1 --S--Ar2 wherein R1 represents a nonmetal bridging... | 08/19/2003 |
| 6583165 | Arylsulfonanilide ureas The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 06/24/2003 |
| 6562965 | Convergent synthesis of -aryl-ଲ-ketonitriles The present invention relates to processes for the production of -aryl-ଲ-ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) rece... | 05/13/2003 |
| 6552225 | Chemical compounds A compound of formula (I) wherein: R1, R2, R3, R4, R5, R6 and R7 are as defined within; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. Th... | 04/22/2003 |
| 6545152 | R-isomers of nonnucleoside inhibitors Novel chiral derivitaves of non-nucleoside inhibitors (NNI), particularly R-isomers of halopyridyl and thiazoyl thiourea compounds are provided as potent inhibitors of reverse transcriptase (RT), and particularly of retroviral RT, most particularly HIV RT... | 04/08/2003 |
| 6541471 | Benzenesulphonamide compounds A compound of formula (I): ##STR1## wherein: G represents a group such as: ##STR2## wherein R1 and R2 independently represent a hydrogen atom or an alkyl, cycloalkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or h... | 04/01/2003 |
| 6531471 | Morpholinone and morpholine derivatives and uses thereof This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholest... | 03/11/2003 |
| 6521619 | Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents The present invention relates to novel cyclopropane-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or ... | 02/18/2003 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
