Class 544/153 - The five-membered hetero ring is one of the cyclos in a polycyclo ring system

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds in which the additional hetero ring is a cyclo
No. of patents: 196
Last issue date: 03/16/2010

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Number	Title	Issue Date
7678904	Use of parthenolide derivatives as antileukemic and cytotoxic agents The present invention provides compounds of the formula (I) wherein: X1, X2 and X3 are heteroatoms; R4, R5, R...	03/16/2010
7439373	Crystalline mycophenolate sodium Provided are crystalline mycophenolate sodium forms and processes for their preparation. ...	10/21/2008
7417145	Process for total synthesis of ecteinascidins and intermediates therefor An intermediate compound for total synthesis of ecteinascidins comprising, a compound represented by general formula 2 having thioether group at C4 site, and the substituent R2 of N12 site is trichloroethoxicarbonyl (Troc) to which various subs...	08/26/2008
7312242	Use of parthenolide derivatives as antileukemic and cytotoxic agents Compounds of the formula having anti-tumor activity, wherein R1 and R2 are as described herein ...	12/25/2007
7244730	2-iminopyrrolidine derivatives A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, et...	07/17/2007
7223789	Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the...	05/29/2007
7144890	Spiro-pentacyclic compounds The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are useful for the treatment and/or prophyl...	12/05/2006
7119214	Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A):	10/10/2006
7034110	Method of identifying chemical compounds having selected properties for a particular application A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reac...	04/25/2006
7019133	Process for making mycophenolate mofetil by transesterification A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenol...	03/28/2006
6919335	Heterocycles that are inhibitors of IMPDH enzyme Compounds of the formula wherein X1 is C(O), —S(O)—, or —S(O)2—; X2 is CR3 or N; X3 is —NH—, —O—, or —S—; X4 is ...	07/19/2005
6900227	Benzodioxole derivatives The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective mo...	05/31/2005
6878706	Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B...	04/12/2005
6846817	Nicotine receptor ligands The invention provides nicotine receptor agonists of formula I: wherein R1, x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceut...	01/25/2005
6835832	Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic co...	12/28/2004
6780859	Benzofuran and dihydrobenzofuran derivatives useful as beta-3 adrenoreceptor agonists This invention relates to novel benzofuran and dihydrobenzofuran compounds, pharmaceutical compositions containing such compounds, and methods of treating beta-3 adrenoreceptor-mediated conditions with such compositions. ...	08/24/2004
6774233	Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic c...	08/10/2004
6743788	Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are ...	06/01/2004
6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds.	05/04/2004
6709846	Methods of producing esters of mycophenolate Methods for the manufacture of Mycophenolate are disclosed. Mycophenblate mofetil is biochemically synthesized using Mycophenolic Acid and 2-morpholino ethanol with the help of an enzyme. Mycophenolate mofetil is also chemically synthesized non-catalytically by refl...	03/23/2004
6703407	Benzofuran compounds, compositions, and methods The present invention provides novel, reduced benzothiophenes of formula I ##STR1## wherein R is --H, --OH, --O(C1 -C4 alkyl), --O--CO--(C1 -C6 alkyl), --O--CO--Ar in which Ar is optionally substituted phenyl, or...	03/09/2004
6653328	3-benzyl-benzothiophenes This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are ଱-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indi...	11/25/2003
6645960	Antifungal sordaricin derivatives A compound of general formula (I) and physiologically acceptable salts wherein R represents phthalidyl, (2-oxo-5-methyl-1,3-diox-olen-4-yl)methyl or the group CHR4 OCO(O)pR5 wherein R4 is hydrogen or C1-4 alcyl,...	11/11/2003
6610687	Benzofuranylsulfonates ##STR1## The invention relates to benzofuranylsulfonates of the general formula (I), their preparation and their use for the treatment of inflammation....	08/26/2003
6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##...	08/19/2003
6512000	Aminocarbonyl-substituted benzimidazoles having tryptase-inhibitory activity A method for treating diseases in which tryptase inhibitors may be of thereapeutic value, which comprises the administration of a thereapeutic amount of a compound of the formula ##STR1## The invention also comprises novel compounds of the formula (I). Exempla...	01/28/2003
6492394	Sulfonamide hydroxamates A compound of the Formula (I): ##STR1## wherein Z, R1, R, and Ar2 are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceu...	12/10/2002
6451817	Alpha-substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are ଱-substituted with ether, thioether, amino, hydrazino, cyano or halo that are useful for the treatment of the various medica...	09/17/2002
6420427	Aminobutyric acid derivatives An aminobutyric acid derivative of the formula (I): ##STR1## (wherein all symbols are as defined in the specification) and salt thereof. salt thereof. The compounds of the formula (I) possess an inhibitory activity on matrix metalloproteinase and are usef...	07/16/2002
6407243	Benzofuran compounds, compositions, and methods The present invention provides novel compound of the formula: ##STR1## wherein Ra is --OH or --O--(C1 -C4 alkyl); R1a is --OH or --O--(C1 -C4 alkyl); n is 2 or 3; R2 and R3 are ...	06/18/2002
6399634	Benzothiophene compounds, compositions, and methods The present invention provides method of treating endometriosis using novel benzothiophene compounds of formula I ##STR1## wherein R is --H, --OH, --O(C1 -C4 alkyl), --O--CO--(C1 -C6 alkyl), --O--CO--Ar in which...	06/04/2002
6395755	Benzothiophene pharmaceutical compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), OCOO(aryl)...	05/28/2002
6391892	Naphthyl pharmaceutical compounds The present invention provides a compound of formula I ##STR1## wherein R1 is H, OH, halo, OCO(C1 -C6 alkyl), OCO(aryl), OSO2 (C4 -C6 alkyl), OCOO(C1 -C6 alkyl), OCOO(aryl)...	05/21/2002
6384053	଱-substituted-1-benzyl-napthyls This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 1-benzyl-naphthyls which are ଱-substituted with ether, thioether amino, cyano or halo that are useful for the treatment of the various medical indication...	05/07/2002
6265575	Antithrombotic diamines This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparat...	07/24/2001
6251921	Antithrombotic diamines This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparat...	06/26/2001
6201126	Isoindolenineamide dyestuffs Compounds of the formula (I) ##STR1## in which A represents N or a cyanomethylene radical, B represents S, O or NH and R1, R2, R3 and x have the meaning given in the description, are highly suitable for dyeing and printing high...	03/13/2001
6174883	3-substituted-2-oxindoles derivatives This invention relates to novel 3-substituted-2-oxindole derivatives of the formula ##STR1## and the phamaceutically-accepted salts thereof which are inhibitors of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. T...	01/16/2001
6087359	Thioaryl sulfonamide hydroxamic acid compounds A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhi...	07/11/2000
6034239	Tricyclic compounds, their production and use A compound of the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon, amino or heterocyclic group; R2 is H or an optionally substituted hydrocarbon group; R3 is H or an optionally substituted hydroc...	03/07/2000

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Class 544/153 - The five-membered hetero ring is one of the cyclos in a polycyclo ring system