Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 7405211 | Therapeutic morpholino-substituted compounds Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as othe... | 07/29/2008 |
| 7262296 | Substituted aryl alkenoic acid heterocyclic amides The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value bu... | 08/28/2007 |
| 7226918 | DNA-PK inhibitors The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are indepen... | 06/05/2007 |
| 7057040 | Substituted aryl alkenoic acid heterocyclic amides The present invention relates to novel compounds possessing specific hot, pungent and spicy taste when subjected to direct pungency evaluation, which may be useful as food additives and anti-oxidants, however the said compounds do not add to any nutritional value bu... | 06/06/2006 |
| 6949537 | PI-3 kinase inhibitor prodrugs The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 09/27/2005 |
| 6846817 | Nicotine receptor ligands The invention provides nicotine receptor agonists of formula I: wherein R1, x, y, and n have any of the values given in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceut... | 01/25/2005 |
| 6844336 | 4-fluoroalkyl-2h-benzopyrans with anti-estogenic activity This invention describes the new 4-fluoroalkyl-2H-benzopyrans of general formula I, in which Z is a straight-chain or branched-chain alkyl group with up to 5 carbon atoms that is fluo... | 01/18/2005 |
| 6699860 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.... | 03/02/2004 |
| 6642380 | Fluorescent group-containing carbodiimide compound precursor, fluorescent group-containing carbodiimide compound and methods for producing them A novel fluorescent group-containing carbodiimide compound having at least one group selected from a carboxyl group, a sulfo group, a phosphono group and a phospho group which have substitution of an alkali metal, an alkaline earth metal or a basic group ... | 11/04/2003 |
| 6638972 | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ##STR1##... | 10/28/2003 |
| 6608089 | Derivatives of flavones, xanthones and coumarins Compounds having the formula (I) Z--OCH2 --C.ident.CCH2 --NRR1 (I) or a pharmaceutically acceptable salt or solvate thereof wherein Z can represent the formula (1A) or (1B). ##STR1## The compounds possess antiproliferative act... | 08/19/2003 |
| 6552054 | Chromone derivatives, process for the preparation of the same and uses thereof The invention provides chromone derivatives of the following general formula, a process for preparing such chromone derivatives and a prophylactic and therapeutic agent comprising such chromone derivatives for bone diseases and chondropathy: ##STR1##... | 04/22/2003 |
| 6372739 | Compounds and methods for modulation of estrogen receptors Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same: ##STR1## wherein R1, R2, R3, n and p are ... | 04/16/2002 |
| 6359132 | Aminomethylation of tocopherols A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced fro... | 03/19/2002 |
| 6316494 | cis3, 4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of estro... | 11/13/2001 |
| 6291456 | Compounds and methods for modulation of estrogen receptors Compounds that modulate gene expression through the estrogen receptor (ER) are disclosed having the following structure, as well as pharmaceutical compositions containing the same: ##STR1## wherein R1, R2, R3, n and p are ... | 09/18/2001 |
| 6194450 | Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structura... | 02/27/2001 |
| 6150356 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure ##STR1## where A, B, D, Q, X1, R, R1, X2 and R2 are as defined herein. These compounds... | 11/21/2000 |
| 6124284 | Bicyclic amide derivatives and their use as muscle relaxants Novel compounds of formula (1) together with their salts and solvates have a number of uses in medicine, in particular as central muscle relaxants.... | 09/26/2000 |
| 6066731 | Aminomethylation of tocopherols A process for the production of a Mannich reagent comprises reacting formaldehyde, especially paraformaldehyde, with a secondary amine in the complete or almost complete absence of a solvent. An alternative comprises reacting a diaminomethane produced fro... | 05/23/2000 |
| 6034256 | Substituted benzopyran derivatives for the treatment of inflammation A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X, A1, A2, A3, A4, R, R",... | 03/07/2000 |
| 5994390 | Trans-3,4-chroman derivatives useful in the prevention or treatment of estrogen related diseases or syndromes The present invention relates to therapeutically active compounds of formula I ##STR1## a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in the prevention or treatment of ... | 11/30/1999 |
| 5968939 | Aromatic derivatives substituted by a ribose, their preparation process and their use as medicaments A subject of the invention is the compounds of formula (I): ##STR1## having antibiotic properties.... | 10/19/1999 |
| 5969140 | Naphthalene derivatives, process for the preparation thereof, and intermediates therefor Naphthalene derivatives of the formula [I]: ##STR1## wherein R1 and R2 are the same or different and are each H, protected or unprotected OH, one of R3 and R4 is protected or unprotected hydroxymethyl, and ... | 10/19/1999 |
| 5955607 | Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or diagnostic, and pharmaceutical preparations comprising them Compounds of the formula I ##STR1## having the meanings of the substituents indicated in the claims are outstandingly efficacious substances for producing medicaments for the prophylaxis and for the therapy of cardiovascular disorders, in particular ... | 09/21/1999 |
| 5889003 | Flavone compounds A compound of general formula (I): ##STR1## in which: R1 represents alkyl, X represents oxygen, --CHR'-- or --CR'.dbd., R' is chosen from hydrogen and alkyl, R2 represents optionally substituted alkyl as is defined in the description... | 03/30/1999 |
| 5872118 | Bicyclic amide derivatives and their use as muscle relaxants Novel compounds of formula (I) ##STR1## wherein R1, R2, R3 and R4 are each selected from hydrogen and fluoro and at least one and not more than two is fluoro; R5 is selected from hydrogen and C1 | 02/16/1999 |
| 5856479 | Fluorescent group-containing carbodiimide compound Using the fluorescent group-containing carbodiimide compound represented-by the following formula (I) as the label and the like in the nucleic acid detection method, immunoassay, or chemiluminescence assay, labeling can be made efficiently for a short tim... | 01/05/1999 |
| 5849798 | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following stru... | 12/15/1998 |
| 5837702 | 4-arylamino-benzopyran and related compounds Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH2 --, --C(O)--, --O--, --S-- or --N(R8)-- where R8 is hydrogen, alkyl, haloalkyl, aryl, a... | 11/17/1998 |
| 5795981 | Processes for the preparation of squarylium dyes Squarylium compounds of the formula: ##STR1## (in which Q1 and Q2 are each a chromophoric group having an aromatic unsaturated system conjugated with the squarylium ring and such that in the compounds of formulae Q1 C... | 08/18/1998 |
| 5747528 | Chroman derivatives as anti-oxidants Chroman derivatives of Formula I or a pharmaceutically acceptable salt thereof are inhibitors of VCAM-1 and ICAM-1 and are thus useful in the treatment of inflammation, atherosclerosis, restenosis, and immune disorders such as arthritis and transplant rej... | 05/05/1998 |
| 5731293 | Esculetin derivatives, method for manufacture thereof, and pharmaceutical composition A compound of the formula (I): ##STR1## wherein R1 and R2 are, independently, --CON(R4)R5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R1 and R | 03/24/1998 |
| 5719145 | Amidine derivatives and platelet aggregation inhibitor containing the same The invention relates to a substituted amidine derivative which has an excellent platelet aggregation inhibiting action on the basis of fibrinogen antagonism and is particularly excellent in effectiveness on oral administration, and the platelet aggregati... | 02/17/1998 |
| 5703075 | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones This invention relates to compounds of Formula I ##STR1## which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. In addition, various compounds of Formula I are useful inhibitors of cell proliferation.... | 12/30/1997 |
| 5686486 | 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkylb!pyran-2-ones useful to treat retroviral infections The present invention relates to compounds of formula I which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkylb!pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## Wherein R1... | 11/11/1997 |
| 5656750 | Processes for the preparation of squarylium dyes Squarylium compounds of the formula: ##STR1## (in which Q1 and Q2 are each a chromophoric group having an aromatic unsaturated system conjugated with the squarylium ring and such that in the compounds of formulae Q1 C... | 08/12/1997 |
| 5650456 | Coumarin derivatives, a method of preparing them and their use as intermediates This invention relates to coumarin derivatives of formula (I) ##STR1## where Z represents OR3 or NR4 R5, to their preparation, and to their use for the production of polymers with luminophors on their side chains.... | 07/22/1997 |
| 5607939 | Condensed heterocyclic compounds, their production and use The compound ##STR1## wherein ring A represents a benzene ring; Ar represents an aromatic group; R1 and R2 independently represent hydrogen, acyl or hydrocarbon group or R1 and R2 taken together with the ad... | 03/04/1997 |
| 5605896 | Bicyclic heterocyclic derivatives having 1 adrenergic and 5HT1A activities This invention provides bicyclic heterocyclic derivatives and their pharmaceutically acceptable salts useful for the treatment of hypertension, urethral and lower urinary tract contractions, and other disorders. The compounds are also useful for binding &... | 02/25/1997 |
