Class 544/146 - Thiophene ring (including hydrogenated)

Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the additional hetero ring consists of
No. of patents: 254
Last issue date: 11/04/2008

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Number	Title	Issue Date
7446195	High affinity thiophene-based and furan-based kinase ligands Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The inve...	11/04/2008
7396944	Thiophene derivatives, their manufacture and use as pharmaceutical agents Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as we...	07/08/2008
7365196	Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ...	04/29/2008
7326785	Pyrrolidine derivatives as factor XA inhibitors The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical cond...	02/05/2008
7288538	Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use. ...	10/30/2007
7238713	Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial effect. In the method, an effective amount of a compound is administe...	07/03/2007
7153980	Thiophene-containing compound and thiophene-containing compound polymer The present invention relates to a thiophene-containing compound and a thiophene-containing compound polymer which are useful for organo-electronic devices such as electrophotographic photoreceptors (photosensitive elements), organic electroluminescent elements and ...	12/26/2006
7105513	Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines, to pharmaceutical compositions comprising such compounds, to methods for the stimulation of the expression of endothelial NO synthase, and methods of treatment comprising administeri...	09/12/2006
7094801	Chalcone derivatives and their use to treat diseases The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the ...	08/22/2006
7034110	Method of identifying chemical compounds having selected properties for a particular application A method for obtaining compounds having selected properties for a particular application by forming base modules having at least two structural diversity elements from the reaction of a first compound having at least one structural diversity element and a first reac...	04/25/2006
6897211	Thienodibenzoazulene compounds as tumor necrosis factor inhibitors The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and interleukine 1 (IL-1) in mammals at all diseases and conditions wher...	05/24/2005
6881735	Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically a...	04/19/2005
6878706	Cyanamides useful as reversible inhibitors of cysteine proteases Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B...	04/12/2005
6841669	Functionalized thiophene oligomers and their use as fluorescent markers Thiophene oligomers which are excitable in the visible and ultraviolet region and each having at least one functional group able to form a covalent bond with organic and/or biological molecules, so as not to alter either the fluorescence properties of the oligomers ...	01/11/2005
6835832	Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic co...	12/28/2004
6831080	Cinnamide derivatives as KCNQ potassium channel modulators There is provided novel cinnamide derivatives of Formula I: wherein R is C1-4 alkyl or trifluoromethyl; R1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-ben...	12/14/2004
6784173	Aromatic dicarboxylic acid derivatives Compounds of formula I wherein A, R1 and R2 are defined in the specification. These compounds are useful as HDAC inhibitors. Also disclosed are methods of making and using said compounds. ...	08/31/2004
6743788	Carbamate and oxamide compounds Disclosed are novel aromatic compounds of the formula(I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory diseases. Also disclosed are ...	06/01/2004
6730671	Compounds useful as reversible inhibitors of cathespin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes, for making such novel compounds.	05/04/2004
6608057	Compounds useful as reversible inhibitors of cathepsin S Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds ##STR1##...	08/19/2003
6534651	7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof The invention provides a novel class of substituted isoindolinone derivatives, useful for the treatment of inflammation and reperfusion injuries. Pharmaceutical compositions, and methods of making and using the compounds, or pharmaceutically acceptable sa...	03/18/2003
6514967	Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): ##STR1## in which: R1 and R2 represent a hydrogen atom, or form a ring, especially a benzene ring, R3 represents a hydrogen atom or an alkyl group, e...	02/04/2003
6506748	Aromatic heterocyclic compounds as antiinflammatory agents Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving in...	01/14/2003
6498172	Prostaglandin agonists and their use to treat bone disorders This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for t...	12/24/2002
6495683	4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamides as antiviral agents The invention provides a compound of formula I: ##STR1## wherein R1, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and in...	12/17/2002
6486332	Fluorescent pigments Compounds of formula A(B)x, (I) wherein x is an integer from 1 to 4, A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which ...	11/26/2002
6472531	Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-...	10/29/2002
6455520	Benzamide derivatives and their use as cytokine inhibitors The invention concerns amide derivatives of formula (I) ##STR1## wherein R3 is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R1 and R2 is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R	09/24/2002
6451791	Amidoaromatic ring sulfonamide hydroxamic acid compounds An amidoaromatic ring sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed, as are a treatment process that comprises administering a contemplated amidoaromatic ring sulfonamide hydroxamic acid compoun...	09/17/2002
6440899	Cyclohexenonedioxothiochromanoyl derivatives Cyclohexenonedioxothiochromanoyl derivatives of the formula I ##STR1## where X is oxygen, sulfur, S.dbd.O, S(.dbd.O)2, CR4 R5, C.dbd.O or C.dbd.NR6, the other substituents are as defined in the specification, an...	08/27/2002
6440958	Acrylic and propionic acid compounds, intermediates, processes, compositions, and methods This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation ...	08/27/2002
6436980	Peptidomimetic efflux pump inhibitors Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds....	08/20/2002
6432982	Benzothiophenes, and formulations and methods using same The invention provides novel benzothiophenes of the formula: ##STR1## wherein R1 is --H, --OH, --O(C1 -C4 alkyl), --O--CO(C1 -C6 alkyl), --OSO2 (C4 -C6 alkyl, or --OCOAr wh...	08/13/2002
6417199	3-benzyl-benzothiophenes This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are a-substituted with ether, thioether amino, hydrazino, cyano or halo that are useful for the treatment of the various medical...	07/09/2002
6403835	Acylation of an organic group over a zeolite The invention relates to the shape selective acylation of an organic compound. In particular, the invention describes a process for such acylation wherein the process comprises reducing the number of surface acid sites without dealuminations on at least a...	06/11/2002
6399778	Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxybenzo[b]thiophenes The present invention is directed to chemical processes for preparing 2-aryl-6-hydroxy-3-[4-(2-aminoethoxy)benzoyl]benzo[b]-thiophenes. The present invention is also directed to crystalline solvates and a non-solvated crystalline form of 6-hydroxy-2-...	06/04/2002
6362183	Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds An aromatic sulfonyl alpha-hydroxy hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease activity is disclosed, as is a treatment process that comprises administering a contemplated aromatic sulfonyl alpha-hydroxy hydroxamic acid comp...	03/26/2002
6335334	Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them The present invention relates to compounds of the formula I ##STR1## wherein A1, A2, R1, R2, R3, X and n are as defined in the claims, which are valuable pharmaceutically active compounds for the ther...	01/01/2002
6288105	Antithrombotic agents This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ...	09/11/2001
6284756	Antithrombotic agents This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the ...	09/04/2001

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Class 544/146 - Thiophene ring (including hydrogenated)