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Class 544/12 - 1,2,4-benzothiadiazines


Subclass of Class 544 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the sulfur atom is in the 1-position and
No. of patents: 73
Last issue date: 08/07/2012


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NumberTitleIssue Date
82369485,6-dihydro-1H-pyridin-2-one compounds
The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I wherein X is N, and A is ...
08/07/2012
8222405Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. ...
07/17/2012
7541459Method of producing amide compound
The present invention provides a method of producing a compound represented by the following formula (1) or a compound represented by the following formula (4) or a tautomer thereof, the method including reacting a compound represented by the following formula (2) o...
06/02/2009
7425552Pyridazinone compounds
The invention is directed to pyridazinone compounds of Formula I and pharmaceutical compositions containing compounds of Formula I wherein R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or het...
09/16/2008
7423034Benzothiazine and benzothiadiazine compounds
Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or h...
09/09/2008
7378414Anti-infective agents
Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia...
05/27/2008
7268130Benzothiadiazine compounds
The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy...
09/11/2007
7268129Fluorinated benzothiadiazine compounds
Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group sel...
09/11/2007
7262191Benzothiadiazine compounds
The invention relates to compounds of formula (I): wherein: X represents oxygen or sulphur, R1 represents linear or branched (C1-C6
08/28/2007
7262190Benzothiazine and benzothiadiazine compounds
The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ...
08/28/2007
7250411Benzothiazine and benzothiadiazine compounds
Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be i...
07/31/2007
7235548Compounds and their use as positive AMPA receptor modulators
The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a...
06/26/2007
7196194Dye-forming coupler, silver halide photographic light-sensitive material and azomethine dye compound
A yellow dye-forming coupler represented by formula (I): wherein Q represents a group of nonmetallic atoms that form a 5- to 7-membered ring in combination with the —N═C—N(R1)—; R1 and...
03/27/2007
7125988Dye-forming coupler and silver halide color photographic light-sensitive material
A yellow dye-forming coupler represented by formula (I): wherein Q represents a group of nonmetallic atoms that form a 5- to 7-membered ring in combination with the —N═C—N(R1
10/24/2006
7091200Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists
This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is...
08/15/2006
7009048Dye-forming coupler, silver halide photographic light-sensitive material, and method for producing an azomethine dye
A dye-forming coupler of the formula (I). A silver halide photographic light-sensitive material that contains at least one dye-forming coupler of the formula (I). A method for producing an azomethine dye, which method comprises using a compound of the formula (I):
03/07/2006
6943159Compounds and their use as positive AMPA receptor modulators
The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substitu...
09/13/2005
6919331Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatm...
07/19/2005
6656932Benzo thiadiazine matrix metalloproteinase inhibitors
Selective MMP-13 inhibitors are benzo thiadiazines of the Formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R2 is hydrogen or alkyl; R1 and R3 include hydrogen, alkyl, and aryl, with the proviso that ...
12/02/2003
6436927IL-8 receptor antagonists
The present invention involves certain 8-ureido and 8-thioureido, 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8....
08/20/2002
62424431,2,4-benzothiadiazine derivatives, their preparation and use
1,2,4-Benzothiadiazine derivatives represented by formula ##STR1## wherein D, R1, R2, R3, R4, R5, R12, R13, R14, R15 are defined in the description, composition ...
06/05/2001
5629311Substituted cyclohexanol esters their use for treating diseases and pharmaceutical preparations
Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparations Cyclohexanol esters of the formula I ##STR1## are described in which the radicals have the meaning given herein. The compounds are pharmacologically act...
05/13/1997
5536723S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier. The invention also relates to methods for ...
07/16/1996
5401739Benzothiadiazine derivatives
A benzothiadiazine derivative, hydrate thereof and acid addition salt thereof, the derivative being represented by the general formula (I) ##STR1## wherein X is methylene or a nitrogen atom substituted with a lower alkyl, Y and Z are each methylene o...
03/28/1995
5378704Non-peptidic angiotensin-II-receptor-antagonists
Novel compounds having the formula ##STR1## wherein R1, R2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents....
01/03/1995
5308857Furylthiazole derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
The invention relates to compounds of the formula: ##STR1## wherein R1, R2, R3, R4, A and Q are as described, useful in the treatment of ulcers....
05/03/1994
52740971,3-disubstituted pyrrolidines
Novel 1,3-disubstituted pyrrolidines active on the central nervous system of the formula ##STR1## wherein A--denotes phenyl or hetaryl, which is optionally fused with aromatic, saturated or unsaturated cyclic or heterocyclic hydrocarbons, where ...
12/28/1993
51872762-pyrimidinyl-1-piperazine derivatives
The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of ...
02/16/1993
5025001S-nitroso derivatives of ACE inhibitors and the use thereof
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically acceptable carrier. The invention also relates to methods for ...
06/18/1991
4997833Aryloxy-aminoalkanes, and antihypertensive use thereof
Aryloxy-aminoalkanes useful as antihypertensive agents are described and disclosed....
03/05/1991
49888092-pyrimidinyl-1-piperazine derivatives, processes for their preparation and medicaments containing them
The invention relates to substituted 2-pyrimidinyl-1- piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of...
01/29/1991
4939140Heterocyclic oxophthalazinyl acetic acids
A heterocyclic oxophthalazinyl acetic acid having aldose reductast inhibitory activity of the formula ##STR1## wherein X is oxygen or sulfur; Z is a covalent bond, O, S, NH or CH2 or CHR5 Z is vinyl; R1 is hydroxy, or...
07/03/1990
49373432-pyrimidinyl-1-piperazine derivatives
The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of ...
06/26/1990
4927824Fungicidal trisubstituted 1,3,5-triazine-2,4,6-triones
Fungicidal trisubstituted 1,3,5-triazine-2,4,6-triones of the formula ##STR1## in which R1 stands for an optionally substituted aliphatic, aromatic or cycloaliphatic radical, R2 stands for an optionally substituted aliphatic radical ...
05/22/1990
4889851Benzothiadiazine compounds, and pharmaceutical composition comprising the same
A compound of the formula: ##STR1## wherein R' is phenyl, phenyl which is substituted with halogen, lower alkyl, lower alkoxy, halo lower alkyl, lower alkylamino, lower alkylthio, phenoxy, carboxy, lower alkoxycarbonyl, carboxy lower alkyl, lower ...
12/26/1989
4883800Quinazoline derivatives and process for their production
The invention relates to compounds having aldose reductase-inhibitory activity of the formula: ##STR1## in which R1 and R2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R3 is phenyl(lower)alkyl which m...
11/28/1989
48187562-pyrimidinyl-1-piperazine derivatives, processes for their preparation and medicaments containing them
The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of ...
04/04/1989
4749698Antihypertensive derivatives
Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity....
06/07/1988
4746676Carboxyalkyl dipeptide compounds
Compounds having the general structure ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are defined herein, which exhibit antihypertensive activity....
05/24/1988
4734419Quinazoline derivatives, compositions thereof and their use in treating diabetic complications
The invention relates to compounds of the formula: ##STR1## in which R1 and R2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl, R3 is dihalophenyl, naphthyl(lower)alkyl, phenyl(lower)alkyl substituted by ...
03/29/1988
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