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| Number | Title | Issue Date |
| 7579461 | Processes for the preparation of rocuronium bromide and intermediates thereof A novel process for preparing (2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed. ... | 08/25/2009 |
| 7199114 | Triterpene quaternary salts as biologically active surfactants The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties. ... | 04/03/2007 |
| 6884799 | Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and process thereof The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepines compounds of general formula V as shown below, which are useful as potential antitumour agents and a process of preparing these compounds; particularly the present invention provides a process... | 04/26/2005 |
| 6262042 | 17ଲ-amino and hydroxylamino-11ଲ-arylsteroids and their derivatives having agonist or antagonist hormonal properties The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.... | 07/17/2001 |
| 5994334 | Androgen synthesis inhibitors This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. Novel compounds according to the present invention are steroid derivatives. These compounds are preferab... | 11/30/1999 |
| 5994335 | 17-azolyl steroids useful as androgen synthesis inhibitors Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.... | 11/30/1999 |
| 5817803 | Process for preparing neuromuscular blocking agents and intermediates useful therefor The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R1 is .dbd.O and X is halo; and formula I... | 10/06/1998 |
| 5679788 | 11 beta-substituted-19 nor-steroids Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the substituents are defined in the specification.... | 10/21/1997 |
| 5591735 | Androstane derivatives substituted by a quaternary ammonium group in 16-position, pharmaceutical compositions containing them and process for preparing same There is disclosed novel, therapeutically active androstane derivatives having neuromuscular blocking effect, which are substituted by a quaternary ammonium group in 16-position; pharmaceutically composition containing them; process for producing them; an... | 01/07/1997 |
| 5591733 | Methods, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionoph... | 01/07/1997 |
| 5556846 | 17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene derivatives active on the cardiovascular system, and pharmaceutical compositions containing same 17-Heterocyclyl-5-14ଲ-androstane, androstene and androstadiene of formula (I): ##STR1## wherein: Y is oxygen or guanidinoimino, when a double bond exists at position 3; Y is hydroxy, OR2 or SR2, when a single bond e... | 09/17/1996 |
| 5449795 | Process for synthesis of steroidal allylic tert. alcohols A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is to the sulfoxide, in an inert solven... | 09/12/1995 |
| 5410040 | Diamino-androstane derivatives New monoquaternary and diquaternary 5-alpha-hydroxy-3,16-diaminoandrostane salts are disclosed with curare-like muscle relaxant activity. The new salts are characterized by a surprisingly rapid onset time.... | 04/25/1995 |
| 5319115 | Method for making 3-hydroxy, 3ଲ-substituted-pregnanes This invention provides a simplified method for converting pregnan-3,20-dione compounds to 3-hydroxy,3ଲ-substituted-pregnanes. By selective use of reagents the unprotected dione is converted chemoselectively and diastereoselectively into... | 06/07/1994 |
| 5232917 | Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, insomnia and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-aminobutyric acid receptor-chloride ionoph... | 08/03/1993 |
| 5208227 | Method, compositions, and compounds for modulating brain excitability Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine receptor-chloride i... | 05/04/1993 |
| 5194602 | 9-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids New 9-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9-hydroxyandrost-4-ene-3, 17-dione. The resulting compounds are useful starting compounds in the synthesis of corticosteroids.... | 03/16/1993 |
| 4975537 | Ɗ9(11) -angiostatic steroids Disclosed are Ɗ9(11) -steroids of the formula ##STR1## which have been found to be angiostatic and therefore are useful in the control of embryogenesis, inflammatory conditions, tumor growth as well as other abnormalities.... | 12/04/1990 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4894369 | Novel 2ଲ-morpholino-androstane derivatives Compounds having the formula: ##STR1## wherein R1 is H or an optionally substituted acyl group having 1-12 carbon atoms, R2 is H or an acyl group having 1-12 carbon atoms and R3 is C, N--CH3 or a direct bond; an... | 01/16/1990 |
| 4891366 | Novel 2ଲ,16ଲ-diamino-androstanes 2ଲ,16ଲ-diamino-3,17-oxygenated androstanes having one quaternized group, process for the preparation of these compounds and pharmaceutical compositions comprising such compounds as the active ingredient. The aforementioned compou... | 01/02/1990 |
| 4447425 | Mono- and bisquaternary ammonium derivatives of 2ଲ,16ଲ-di-amino-5-androstane derivatives and pharmaceutical preparations containing same This invention relates to novel mono- and bisquaternary ammonium derivatives of 5-androstanes having the formula: ##STR1## wherein: R1 =H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the ... | 05/08/1984 |
| 4348390 | Novel bis- and mono-quaternary ammonium derivatives of 2ଲ,16ଲ-dipiperidino-5-androstanes, processes for their preparation and pharmaceutical preparations The invention relates to novel bisquaternary ammonium derivatives of 2ଲ,16ଲ-dipiperidino-5-androstanes having the formula: ##STR1## wherein ##STR2## R2 =CH3, C2 H5 or CH2 ... | 09/07/1982 |
| 4297351 | Method of manufacture and use of improved 2ଲ, 16ଲ-piperidino androstanes New and pharmacologically useful pharmaceutically acceptable acid addition salts are disclosed for the 16ଲ-monoquaternary ammonium derivatives of either the 2ଲ, 16ଲ-bis-piperdino-3, 17ଲ-dihydroxy-5-androstane 3... | 10/27/1981 |
| 4237126 | 2ଲ, 16ଲ-bis-piperidino-androstanes New and pharmacologically useful pharmaceutically acceptable acid addition salts are disclosed for the 16ଲ-mono-quaternary ammonium derivatives of either the 2ଲ, 16ଲ-bis-piperdino-3-, 17ଲ-dihydroxy-5-androstane 3 ... | 12/02/1980 |
| 4177190 | Diamino-androstanes and a process for the preparation of the said compounds Curare-type salts of the formula ##STR1## wherein Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of R1 and R2, is a methylene group and the other is a group of the formula >N--R2 | 12/04/1979 |
| 4110326 | Acylated diepoxy-androstane and a process for the preparation thereof A compound of the formula (I) ##STR1## wherein X is a halogen, Z1 and Z2 are both hydrogen, or Z1 is hydroxy and Z2 is chlorine, or Z1 and Z2 together stand for an -epoxy group.... | 08/29/1978 |
| 4101545 | Diamino-androstanes and a process for the preparation of the said compounds Curare-type salts of the formula ##STR1## WHEREIN Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one of R1 and R2, is a methylene group and the other is a group of the formula >N-R2 | 07/18/1978 |
| 4071515 | Triamino-androstanes and a process for the preparation of the said compounds New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.... | 01/31/1978 |
| 4000125 | Novel cardiotonic steroids, process for their preparation and therapeutical use The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R4 is a hydroxy group or a hexopyranoside unit or a chain of t... | 12/28/1976 |
