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| Number | Title | Issue Date |
| 7358359 | Antibacterial agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacteria... | 04/15/2008 |
| 7307074 | Diazepan derivatives or salts thereof To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan derivative such a... | 12/11/2007 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 7141560 | Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I The invention also relates to pharmaceutical compositions comprising said derivatives, and to the use of th... | 11/28/2006 |
| 7105507 | Cyclohexane derivatives and their use as therapeutic agents The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R | 09/12/2006 |
| 7098203 | Homopiperidine derivatives as NK-1 antagonists The present disclosure relates to chemical compounds and their use in human therapy. In a specific embodiment, compounds of Formula (I) or an isomer, a pharmaceutically acceptable salt or solvate thereof or a pharmaceutically acceptable formulation comprising said c... | 08/29/2006 |
| 7012153 | Process for preparing benzoic acids An improved process for the preparation of 4[(2-piperidin-1-yl)ethoxy]benzoic acid derivatives, comprising reacting a haloalkyl amine of formula (III) with a compound of formula (IV) in the presence of a hydrated inorganic base in an appropriate solvent. ... | 03/14/2006 |
| 6951860 | Calcium channel blockers The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calcium channel ... | 10/04/2005 |
| 6818765 | Benzene-sulphonamide derivatives and their uses Benzene-sulphonamide derivatives complying with the general formula (I): in which the different symbols have different meanings, their optical isomers and the salts pharmacologically acceptable of these derivatives, as... | 11/16/2004 |
| 6677332 | Heterocyclic analgesic compounds and methods of use thereof One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-pro... | 01/13/2004 |
| 6642224 | Diazepan derivatives or salts thereof To provide a compound which has an anticoagulation action based upon inhibition of activated blood coagulation factor X and is useful as an anticoagulant or an agent for prevention and treatment of diseases caused by thrombus or embolus. A diazepan deriva... | 11/04/2003 |
| 6534499 | N-substituted-N'-substituted urea derivatives and the use thereof as TNF- production inhibitory agents N-Substituted-N'-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF- production inhibitory activity. ##STR1##... | 03/18/2003 |
| 6525099 | N-substituted sulfonamide derivatives The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 02/25/2003 |
| 6521707 | Isocyanates containing amino groups The invention relates to novel isocyanates containing tertiary amino groups, a process for preparing them, and also their use for the synthesis and modification of polymers. The invention provides isocyanates of the formula (I) ##STR1## where R1... | 02/18/2003 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
| 6455472 | Phenyl-substituted cyclic enaminones The present invention relates to novel phenyl-substituted cyclic enaminones of the formula (I): ##STR1## in which Ar, X, Z, Y, K, n and m are each as defined in the description, to a plurality of processes and intermediates for their preparation and to th... | 09/24/2002 |
| 6417353 | Preparing amines Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing coppe... | 07/09/2002 |
| 6376468 | Protein:prenyl transferase inhibitors The invention pertains to novel peptide analogs suitable for inhibiting protein:prenyl transferases. As such they are therapeutically useful in e.g. inhibiting oncogenesis and other unwanted cell proliferation, and in supressing aberrant high signal trans... | 04/23/2002 |
| 6352981 | Substituted AZA- and diazacycloheptane and -cyclooctane Aza- and diazacyclohexane and -cyclooctane compounds of the following formula: Ar1 --A--B--Ar2 (I) where Ar1, A, B and Ar2 have the meanings stated in the description have a high affinity for the dopamine D3 | 03/05/2002 |
| 6350884 | Acrylic and propionic acid compounds, intermediates, processes, compositions, and method This invention is directed to a class of acrylic and propionic acid compounds and their use in the treatment of post-menopausal symptoms and restenosis. In other embodiments, the invention is directed to intermediates and to processes for the preparation ... | 02/26/2002 |
| 6337398 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: ##STR1## wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/08/2002 |
| 6323223 | Cyclic amine derivatives- CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) ##STR1## that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.... | 11/27/2001 |
| 6075146 | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals The invention relates to intermediates and processes for producing benzothiophenes employing hydroxylamines.... | 06/13/2000 |
| 5962507 | O-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds, and their use, as well as a method of preparing them Compounds that inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase and cholesterol biosynthesis, of the formula I ##STR1## wherein n denotes the number 0 or 1, m denotes the number 1 or 2, p denotes the number 0 or 1, R1 and R2 | 10/05/1999 |
| 5929090 | 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods The present invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; having activity as a selective estrogen receptor modulator, pharmaceutical compositions containing a compound of formula I, and... | 07/27/1999 |
| 5919934 | Compounds, compositions, and methods for cancer imaging and therapy Disclosed are bisaminothiol and amino compounds with appended pharmacophores, complexes of these compounds with 99m Tc(V)0, Re(V)0, In+3, 67 Ga+3, 90 Y+3, 109 Pd+2 or ... | 07/06/1999 |
| 5856318 | Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each o... | 01/05/1999 |
| 5849801 | 4-amino-5-oxy-2,6,6-trimethyl-2-cycloheptene compounds 4-amino-5-oxy-2,6,6-tri methyl-2-cycloheptene compounds represented by the following general formula: ##STR1## (wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group which may have a substituent, or a ph... | 12/15/1998 |
| 5837717 | Hydroxamic acid anesthetic compounds A compound of the following formula: ##STR1## and its pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alkenyl, C1-4 | 11/17/1998 |
| 5763460 | N-(piperidinyl-1-alkyl)-substituted cyclohexane carboxylic acid amides as 5-htia receptor antagonists Compounds of formula (I) and the pharmaceutically acceptable acid addition salts thereof are 5-HT1A binding agents and may be used, for example, as anxiolytics. In the formula a and b each represents 0, 1, 2 or 3 such that the sum of a+b is 0, ... | 06/09/1998 |
| 5741792 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6 ', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as define... | 04/21/1998 |
| 5741799 | Heterocyclic thrombin inhibitors Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R1, R2, R3, G, Gx, R6', Ra, Xa, R6, Rb, R3, p, Q, A and R4 are as defined... | 04/21/1998 |
| 5705509 | Tricyclic heterocyclic compounds as 5-HT4 receptor antagonists Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 --(CH2)x --X2 and the aromatic carbon atoms to which they are attached form 5-7 membered ring wherein X1 is O or S; X... | 01/06/1998 |
| 5686447 | Aminoalkyloximes for treating depression and affective disorders Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5686483 | Aminoalkyloximes Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5686446 | Aminoalkyloximes Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/11/1997 |
| 5684021 | Aminoalkyloximes for treating depression and affective disorders Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.... | 11/04/1997 |
| 5631369 | Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents Novel processes for producing compounds of formula I ##STR1## wherein R1 and R2 each are independently C1 -C4 alkyl, or combine to form piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, m... | 05/20/1997 |
| 5585374 | Amide derivatives Amide derivatives of formula (I) and their pharmaceutically acceptable salts (where a and b each represent 0, 1, 2 or 3 such that a+b=0, 1, 2 or 3, the dotted line represents an optional double bond, A is an optionally substituted C1-2 -alkylen... | 12/17/1996 |
| 5500422 | Benzamide derivative A benzamide derivative represented by the following formula: ##STR1## wherein R1 represents a hydrogen atom or a lower alkanoyl group; R2 represents a hydrogen atom or a halogen atom; R3 represents a lower alkoxy grou... | 03/19/1996 |
