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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7405209 | Protease inhibitors The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such co... | 07/29/2008 |
| 7071184 | Protease inhibitors The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel int... | 07/04/2006 |
| 7030201 | Bottom antireflective coatings The present invention relates to bottom antireflective coating compositions and polymers useful in making such compositions. ... | 04/18/2006 |
| 7008995 | Carboxy resin crosslinkers Carboxy resins of low equivalent weight per carboxyl group are synthesized by reacting a compound having two or more isocyanate groups with a compound having one hydroxyl group and two or more carboxyl groups. In a preferred embodiment, the compound having isocyanat... | 03/07/2006 |
| 6964626 | High temperature polyurethane/urea elastomers The present invention relates to molded polyurethane/urea elastomers, and specifically to improved polyurethane/urea elastomers having high temperature stability to about 140–150° C. and low temperature flexibility at about −35–(−40)° C., for use in dynami... | 11/15/2005 |
| 6958329 | Lactams substituted by cyclic succinates as inhibitors of A-β protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more spec... | 10/25/2005 |
| 6927271 | Hydroxyl and carbamate functional resins Coating compositions contain hydroxyl- or carbamate functional resins with a relatively low equivalent weight. The resins are based on a polyol core containing urea and hydroxyl groups, and made by reacting a polyisocyanate, preferably a triisocyanate, with an amino... | 08/09/2005 |
| 6852713 | Lactam derivatives and methods of their use Lactam derivatives of the general formula are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. ... | 02/08/2005 |
| 6699988 | Process for the preparation of N,N'-carbonylbislactams The invention relates to a process for the preparation of N,N'-carbonylbislactams by reaction of phosgene with at least one lactam which is characterized in that the tertiary amine is chosen from the group consisting of non-nucleophilic aliphatic tertiary... | 03/02/2004 |
| 6566376 | Diphenyl-piperidine derivative The invention provides compounds of general formula (I) ##STR1## wherein R1, R2, R3, R4, A, Q, U, V, W, X, Y and n are as defined in the specification, processes for their preparation, pharmaceutical composition... | 05/20/2003 |
| 6495540 | Lactams as inhibitors of A-ଲ protein production This invention relates to novel lactams having the Formula (I): ##STR1## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the produc... | 12/17/2002 |
| 6476016 | Cyclic oxyguanidine pyrazinones as protease inhibitors Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: ##STR1## wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, solvates or pharmaceutically ... | 11/05/2002 |
| 6448394 | Process for the preparation of an N-alkyl or N-aryl carbamoyl derivative The invention relates to a process for the preparation of an N-alkyl or N-aryl carbamoyl derivative in which an amine is contacted with a carbonic acid derivative according to the general formula: ##STR1## where fragments X in the form of XH are a lactam,... | 09/10/2002 |
| 6344450 | Lactam compounds and their use as inhibitors of serine proteases and method Lactam inhibitors are provided which have the structure ##STR1## X is ##STR2## wherein Y is O or S and R4 is ##STR3## R7 O-- or R8 and R1, R2, R3, R5, R6, R7 | 02/05/2002 |
| 6051678 | Copolymers containing N-vinyllactam derivatives, preparation methods thereof and photoresists therefrom Copolymers containing N-vinyllactam derivatives protected at 3-position are provided and represented by the following formula. The copolymers are used as a photoresist material suitable for deep uv process so that high sensitivity and resolution can be ob... | 04/18/2000 |
| 5972237 | Use of heterocyclic compounds as activators for inorganic peroxy compounds Heterocyclic compounds I R1 --X--L (I) where L is a cyclic carbamate residue, a lactonoxy residue or a lactam residue, X is an oxygen-containing group ##STR1## where A is a linker, and R1 is an ... | 10/26/1999 |
| 5955606 | N-vinyllactam derivatives and polymer thereof N-vinyllactam derivatives protected at the 3-position are provided and represented by the following formula (I). These are polymerized into homo- and copolymers for use in microlithography of semiconductor manufacture. The polymers are used as a photoresi... | 09/21/1999 |
| 5750680 | N-vinyllactam derivatives and polymer thereof N-vinyllactam derivatives protected at the 3-position are provided and represented by the following formula (I). These are polymerized into homo- and copolymers for use in microlithography of semiconductor manufacture. The polymers are used as a photoresi... | 05/12/1998 |
| 5561235 | Multiple-substituted bleach activators Bleaching compositions, laundry and automatic dishwashing detergent compositions comprising multiple-substituted bleach activators which have at least one quaternary nitrogen atom,, are provided. More specifically, the invention relates to compositions wh... | 10/01/1996 |
| 5336706 | Piperidine-triazine compounds for use as stabilizers for organic materials The present invention relates to novel piperidine-triazine compounds of the formula (I) ##STR1## in which R1 is e.g. hydrogen or methyl, A1 is e.g. >N--CH3, R2 is e.g. --(CH.sub. 2)2-6 --, R... | 08/09/1994 |
| 5300647 | O-carbonyl N-hydroxy hindered amine stabilizers Hindered amines based on various 2,2,6,6-tetraalkylated nitrogen-containing heterocyclic moieties wherein the hindered nitrogen atom on the ring is substituted with O-acyl, O-carbamoyl or O-carbonate substituents and the 4-position of the ring is substitu... | 04/05/1994 |
| 5300640 | Pyrimidine derivatives, their production and use A novel herbicidal pyrimidine derivative represented by the formula ##STR1## wherein each of R1, R2, R3, R4, Y1, Y2, Y3, X and Z are as defined herein.... | 04/05/1994 |
| 5149823 | Sulfonamide substituted spirodilactams A novel class of sulfonamoyl-substituted 1,6-diaza[4.4]spirodilactams, having a sulfonamoyl substituent on the hydrocarbyl group attached to each spiro ring nitrogen atom, is useful for the preparation of polymers, including polyamides and as latent curin... | 09/22/1992 |
| 5106971 | Hybrid process for preparing a tri-substituted triazine The prior art solvent process for the manufacture of an oxo-piperazinyl triazine (PIP-T) compound required carrying out the reaction between an appropriately hindered cyclic amine and cyanuric chloride in the presence of caustic catalyst, in alkylbenzene ... | 04/21/1992 |
| 5041545 | 2-hydroxybenzophenone hydrazides and derivatives thereof Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y... | 08/20/1991 |
| 4970306 | Trans-cyclohexane-1,4-diisocyanate which is completely or partially blocked with epsilon-caprolactam: and the manufacture and use of the same The invention relates to trans-cyclohexane-1,4-diisocyanate which is completely or partially blocked with epsilon-caprolactam and a method of manufacturing the same wherein 1 mole trans-cyclohexane-1,4-diisocyanate is reacted with 1 to 2 moles epsilon-cap... | 11/13/1990 |
| 4959361 | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists The invention relates to compounds of the formula ##STR1## wherein X is --CH.dbd.CH-- or S; R1 is lower alkyl, lower alkoxy or trifluoromethyl; R2 is hydrogen, lower alkyl, lower alkoxy, hydroxy or alkanoyloxy; R3 and R | 09/25/1990 |
| 4886890 | Diquarternary nitrogen compounds This invention relates to quaternary compounds having the formula ##STR1## wherein W- is an anion; m and n are integers having a value of from 1 to 4; R is alkylene having from 3 to 8 carbon atoms; R1 is a radical having from 8 ... | 12/12/1989 |
| 4868298 | Continuous process for the production of blocked isocyanate containing polyisocyanurates A continuous method for the high-yield, one-step, solvent-free manufacture of blocked polyisocyanurate compounds useful as curing agents in powder coating compositions. The preferred method of manufacture is to pre-mix a blocking agent and a polymerizatio... | 09/19/1989 |
| 4801586 | Penetration enhancers for transdermal delivery of systemic agents This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said sy... | 01/31/1989 |
| 4792603 | Method of producing a polyether prepolymer A method for producing a polyether-polyamide block copolymer is disclosed, comprising copolymerizing, in the presence of an anionic polymerization catalyst, a lactam and a polyether prepolymer presented by the formula: ##STR1## wherein R1 ... | 12/20/1988 |
| 4767769 | Antiulcer benzimidazole derivatives Compounds of formula I ##STR1## in which R1 and R2, which may be the same or different, are hydrogen, a C1 to C3 alkyl group or R1 and R2 together with the nitrogen to which they are a... | 08/30/1988 |
| 4698412 | Lactam copolymers Copolymers of propylene oxide and N-epoxy propyl lactams having the structures ##STR1## wherein R is ##STR2## a has a value of 1-3; p has a value of 1-2; m has a value of 0-1; k has a value of 2-200; w and z each have a value of 2-50 x and ... | 10/06/1987 |
| 4666902 | Tetrahydropyridazinone derivatives, processes for their preparation and their use Tetrahydropyridazinones of the formula I ##STR1## wherein R denotes an optionally substituted carbocyclic or heterocyclic radical, R1 denotes hydrogen; alkyl; aralkyl, which is optionally substituted in the aryl part; or acyl, and R2 | 05/19/1987 |
| 4650608 | Star block copolymer from lactam and polyol and process for the production thereof A novel star block copolymer represented by the general formula as shown below and a process for the production thereof are described. The copolymer has superior physical properties, particularly impact strength and, furthermore, is reduced in coloration.... | 03/17/1987 |
| 4644051 | Catalytic reaction of polyol with bis-acyl lactam The invention concerns a simple process for preparing an ester acyllactam and/or esteramide acyllactam by the catalytic condensation of imide and alcohol, characterized in that a polyol and an acyllactam compound are reacted in the liquid state in the pre... | 02/17/1987 |
| 4639442 | Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of g... | 01/27/1987 |
| 4628075 | Acid halide functional materials A composition containing acid halide functional materials, which are useful in the preparation of nylon block polymers, selected from the group consisting of: ##STR1## wherein, X is a halogen; b is an integer equal to 2 or more; R1 is an a... | 12/09/1986 |
| 4626385 | N-substituted carbamoyl-lactam An N-substituted carbamoyl-lactam compound of the formula ##STR1## wherein R is a di-valent radical derived from polytetramethylene glycol, R' is an at least divalent radical derived from a diisocyanate, Y is a C3 -C14 ring-form... | 12/02/1986 |
| 4620949 | Process for amidocarbonylation of cyclic amides Amino acid derivatives are synthesized by reacting paraformaldehyde, cyclic amides and synthesis gas with a bimetallic catalyst comprising a rhodium-containing compound and a cobalt-containing compound, optionally in the presence of a solvent at a pressur... | 11/04/1986 |
