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| Number | Title | Issue Date |
| 7414049 | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives The invention relates to 4-oxo-2,3,4,5-tetrahydro-benzo [b][1,4]diazepines of formula I wherein R1, R2, R3 and R4 are as defined in the description and claims, which are γ-secret... | 08/19/2008 |
| 7390801 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 06/24/2008 |
| 7390802 | Substituted lactams as inhibitors of Aβ protein production This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor prote... | 06/24/2008 |
| 7375099 | Malonamide derivatives The invention relates to malonamide derivatives of formula wherein each of the variables are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds are γ-secretase inh... | 05/20/2008 |
| 7304056 | Succinoylamino lactams as inhibitors of Aβ protein production This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-pe... | 12/04/2007 |
| 7186712 | Compositions and methods relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 03/06/2007 |
| 7166587 | Carbamic acid alkyl ester derivatives The present invention provides compounds of the general formula wherein R4 is one of the following groups | 01/23/2007 |
| 7160875 | Malonamide derivatives The invention relates to malonamide derivatives of formula wherein each of the variables are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates and dia... | 01/09/2007 |
| 7151098 | Glutamate receptor antagonists The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification. ... | 12/19/2006 |
| 7138549 | Electrooptic compounds and methods for making Functional optical materials for optical systems that are typically useful in optical waveguides, optical switching systems, optical modulators, optical computing systems and the like. Included are polymer systems and electrooptical chromophores. Polymers are thermo... | 11/21/2006 |
| 7125866 | Therapeutic applications of pro-apoptotic benzodiazepines Benzodiazepinc compounds, and methods for using those compounds are provided. Some of the benzodiazepine compounds include 1,4-benzodiazepine-2-one and 1,4-benzodiazepine-2,5-dione compounds of structures (I) or (II): wherein R1, R2, R3 | 10/24/2006 |
| 7112583 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 09/26/2006 |
| 7053084 | Succinoylamino benzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 05/30/2006 |
| 7018998 | Glutamate receptor antagonists The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification. ... | 03/28/2006 |
| 6962913 | Benzo-1,4-diazepin-2-ones as inhibitors of Aβ protein production This invention relates to novel compounds of the class of succinoyl lactams, such as diazepinee of Formula (Id), or a pharmaceutically acceptable salt thereof, as described above, having drug and bio-affecting properti... | 11/08/2005 |
| 6960578 | Glutamate receptor antagonists The present invention is a compound of formula wherein X is an ethynediyl group, R1, R2 and R3 are as defined in the specification. ... | 11/01/2005 |
| 6949542 | Dihydro-benzo[b][1,4]diazepin-2-one derivatives This invention relates to dihydro-benzo[b][1,4]diazepin-2-one derivatives of the formula wherein R1, R2, X and Y are as defined in the specification and R3 is a six-membered aromatic he... | 09/27/2005 |
| 6916805 | Quinoxalinones as serine protease inhibitors This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable co... | 07/12/2005 |
| 6838455 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 01/04/2005 |
| 6774125 | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 08/10/2004 |
| 6747022 | Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same Provided are calcium salts of a 1,5-benzodiazepine derivative represented by the following formula (I): (wherein, R1 represents a lower alkyl group, R2 represents a phenyl or cyclohexyl group, and Y... | 06/08/2004 |
| 6696438 | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 02/24/2004 |
| 6683075 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 01/27/2004 |
| 6569851 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits ଲ-amylo... | 05/27/2003 |
| 6548495 | Dihydro-benzo [B] [1,4] diazepin-2-one derivatives This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula ##STR1## wherein R1, R2, R3 and Y are as defined in the specification. The invention includes pharmaceutical compositions containing th... | 04/15/2003 |
| 6544985 | Dihydro-benzo [b][1,4]diazepin-2-one derivatives This invention is a dihydro-benzo[b][1,4]diazepin-2-one derivative of the formula ##STR1## wherein R1, R2, R3, X and Y are as defined in the specification. The invention includes pharmaceutical compositions containing... | 04/08/2003 |
| 6407094 | Glutamate receptor antagonists The present invention relates to compounds of with a base structure of formula 1 ##STR1## The compounds of formula I are shown to have activity as metabotropic glutamate receptor antagonists.... | 06/18/2002 |
| 6344452 | 1,5-benzodiazepine derivatives This invention relates to 1,5-benzodiazepine derivatives, which are each represented by the following formula (1): ##STR1## wherein R1 represents a lower alkyl group, R2 and R3 may be the same or different and represent a ... | 02/05/2002 |
| 6258948 | Inhibitors of Interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-IB converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates t... | 07/10/2001 |
| 6239131 | 1,5 Benzodiazepine derivatives 1,5-Benzodiazepine derivatives represented by formula (I), salts thereof, and medicines containing the same as the active ingredient: ##STR1## The compounds exhibit excellent gastrin and/or CCK-B receptor antagonism and are useful as remedies for gastric ... | 05/29/2001 |
| 5985869 | Benzoheterocyclic compounds Novel benzoheterocyclic compounds of the formula: ##STR1## wherein R1 is H, halogen, alkyl, optionally substituted amino, alkoxy; R2 is H, halogen, alkoxy, phenylalkoxy, OH, alkyl, optionally substituted amino, carbamoyl-alkoxy,... | 11/16/1999 |
| 5834463 | Condensed heterocyclic compounds, their production and use Compounds represented by the formula: ##STR1## wherein ring A is benzene; Ar is aromatic group; R1, R2 and R3 each stands for H, acyl, hydrocarbon or heterocyclic, or R2 and R3, taken together, m... | 11/10/1998 |
| 5795887 | Method of inducing cholecystokinin agonist activity using 1,4- Benzodiazepine compounds A method of inducing a Cholescystokinin-A receptor agonist response in a mammal by administering a compound of formula (I), ##STR1## where R1 is C1 -C6 alkyl, C3-6 cycloalkyl, phenyl, or substituted phenyl;... | 08/18/1998 |
| 5726171 | N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzoB!1,4!diazepi n-3yl)-acetamides This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.... | 03/10/1998 |
| 5691332 | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.... | 11/25/1997 |
| 5677299 | Benzoheterocyclic compounds Novel benzoheterocyclic compound of the formula (1): ##STR1## and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist or oxytocin ant... | 10/14/1997 |
| 5569654 | Benzodiazepinones Compounds of general formula (I) ##STR1## and physiologically acceptable salts thereof; wherein R1 represents CH2 CONR5 R6 or CH2 COR7 ; R2 represents a phenyl group optionally s... | 10/29/1996 |
| 5521170 | Benzamide derivatives and pharmaceutical composition comprising the same Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in the liver, activity for ... | 05/28/1996 |
| 5434261 | Benzo-fused lactams promote release of growth hormone There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat pr... | 07/18/1995 |
| 5430144 | Benzo-fused lactams promote release of growth hormone There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat pr... | 07/04/1995 |
