Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 7074783 | Sulfonylbenzodiazepinone acetamides as bradykinin antagonists Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also e... | 07/11/2006 |
| 6653303 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits ଲ-amyloid... | 11/25/2003 |
| 6630475 | Adenosine A2a receptor antagonists Compounds having the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, cycloalkenyl, or heteroaryl; X is alkylene or --C(O)CH2 --; Y is --N(R2)CH2 CH... | 10/07/2003 |
| 6558649 | Vitronectin receptor antagonist pharmaceuticals The present invention describes novel compounds of the formula: (Q)d --Ln --Ch, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present ... | 05/06/2003 |
| 6495545 | 1,4-benzodiazepinone derivatives and their use as integrin antagonists The present invention relates to compounds of general formula (I) and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds.... | 12/17/2002 |
| 6458784 | Vitronectin receptor antagonists Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis. ##STR1##... | 10/01/2002 |
| 6455529 | Adhesion receptor antagonists Compounds of the formula I ##STR1## in which R1, R2 and R3 have the stated meanings, and their physiologically acceptable salts, inhibit the binding of fibrinogen to the corresponding receptor and can be used for the treat... | 09/24/2002 |
| 6403578 | Bicyclic fibrinogen antagonists This invention relates to compounds of the formulae: ##STR1## wherein A1 is O, S, N--R1 or CHR1 ; A4 is N--R4 or CHR4 ; R2 is a sidechain containing an acid or ester group; R1, ... | 06/11/2002 |
| 6339083 | Multiheterocyclic pharmAceuticals The present invention relates to compounds of the general formula (I): ##STR1## and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds.... | 01/15/2002 |
| 6335330 | Crystalline pharmaceutical product This invention provides (S)-7-[(4,4'-bipiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-4-methyl-3-oxo- 1H-1,4-benzodiazepine-2-acetic acid, hydrochloride, processes for its preparation and methods for its use.... | 01/01/2002 |
| 6225465 | Process for the aminocarbonylation of benzazepines and benzodiazepines A new process for preparing substituted 7-aminocarbonyl-3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepines is disclosed.... | 05/01/2001 |
| 6117866 | Bicyclic fibrinogen antagonists Certain compounds within formula (I) are inhibitors of platelet aggregation: ##STR1## wherein A1 is NH or CH2 ; R is H, C1-6 alkyl, benzyl or a carboxy protecting group; R3 is C1-6 alkyl, Ar-C0-6... | 09/12/2000 |
| 6100254 | Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki... | 08/08/2000 |
| 6015791 | Serine protease inhibitors-cycloheptane derivatives The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compoun... | 01/18/2000 |
| 6008214 | Bicyclic compounds This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a me... | 12/28/1999 |
| 5324726 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## wherein: R3 is ##STR2## --NH(CH2)2 --3 NHCOR7, ##STR3## or --X11 NR18 SO2 (CH2)q... | 06/28/1994 |
| 4929269 | Herbicidal sulfonomides Compounds of the formula ##STR1## and salts thereof, W and W, being independently O and S, A being a nitrogen-containing heterocyclic ring system, E being O, S(O)m or NR3 where m is 0-2, R1, R2 and R3 is hy... | 05/29/1990 |
| 4820834 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 04/11/1989 |
| 4592866 | Fused aromatic oxazepinones, thiazepinones, diazepinones and sulfur analogs thereof Aromatic azepinones and thiones having the formula ##STR1## wherein; A is benzene, naphthalene, quinoline or pyridine; B is oxygen or sulfur; E is oxygen, sulfur or ##STR2## n is 1, 2 or 3; Z is an amino or a heterocyclic nitrogen containing rad... | 06/03/1986 |
| 4474777 | Benzodiazepine derivatives and their pharmaceutical use There are presented novel pharmaceutically active substances which inhibit the intestinal resorption of cholesterol and which accordingly can be used in the control or prevention of atherosclerosis. These active substances are benzodiazepines of the formu... | 10/02/1984 |
| 4377522 | Benzodiazepine derivatives There are presented novel benzodiazepine derivatives of the formula ##STR1## wherein R1 is lower alkyl, lower hydroxyalkyl or lower dialkylaminoalkyl, R2 and R3 each are lower alkyl, R4 is halogen, R5 | 03/22/1983 |
| 4361511 | Benzodiazepine derivatives There are presented compounds of the formula ##STR1## wherein R1 is a lower alkyl group, R2 is a hydrogen atom or a lower alkyl group, R3 is a hydrogen or halogen atom, R4 is a hydrogen atom or a group of t... | 11/30/1982 |
| 4299767 | Benzodiazepine derivatives This invention provides benzodiazepine derivatives of the general formula ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a halogen atom and R | 11/10/1981 |
| 4296031 | Benzodiazepine derivatives This invention provides benzodiazepine derivatives of the general formula ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a halogen atom and R | 10/20/1981 |
| 4294758 | 7-Isocyanato-1,4-benzodiazepin-2-ones This invention provides benzodiazepine derivatives of the general formula ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a halogen atom and R | 10/13/1981 |
| 4281188 | N'[3-(halobenzoyl)-4-(glycylamino)phenyl]ureas This invention provides benzodiazepine derivatives of the general formula ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a halogen atom and R | 07/28/1981 |
| 4251443 | Benzodiazepine derivatives This invention provides benzodiazepine derivatives of the general formula ##STR1## wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a halogen atom and R | 02/17/1981 |
| 3989681 | 7-Azoxy substituted-1,4-benzodiazepin-2-ones Novel 1,4-benzodiazepin-2-ones of the formula ##SPC1## Wherein R1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl-lower alkyl, hydroxylower alkyl, lower alkoxy-lower alkyl and di-lower alkylamino-lower alkyl; R2 | 11/02/1976 |
