Class 540/512 - Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium
No. of patents: 39
Last issue date: 07/31/2007

Number	Title	Issue Date
7250410	Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis...	07/31/2007
7160880	Short-acting benzodiazepines The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy. ...	01/09/2007
7109259	Piperazinone derivatives A compound of the formula (I) wherein n is preferably 3; G1, G2, G3 and G4 are independently of one another e.g. C	09/19/2006
7074783	Sulfonylbenzodiazepinone acetamides as bradykinin antagonists Disclosed are compounds, which are bradykinin antagonists and are useful to treat diseases or relieve adverse symptoms associated with disease conditions in mammals mediated by bradykinin. Certain of the compounds exhibit increased potency and are expected to also e...	07/11/2006
7067512	Substituted 1,4-benzodiazepines and uses thereof The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or ...	06/27/2006
6900222	Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein —Z1—Z2	05/31/2005
6495545	1,4-benzodiazepinone derivatives and their use as integrin antagonists The present invention relates to compounds of general formula (I) and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds....	12/17/2002
6458784	Vitronectin receptor antagonists Pharmaceutically active benzodiazapine compounds of formula (I) are disclosed. These compounds inhibit the vitronectin receptor and are useful for treatment of osteoporosis. ##STR1##...	10/01/2002
6403578	Bicyclic fibrinogen antagonists This invention relates to compounds of the formulae: ##STR1## wherein A1 is O, S, N--R1 or CHR1 ; A4 is N--R4 or CHR4 ; R2 is a sidechain containing an acid or ester group; R1, ...	06/11/2002
6369221	Thiazolobenzoheterocycles, preparation and medicines containing same Disclosed are thiazolobenzoheterocycles of the general formula ##STR1## Including their isomers, racemates, enantioners and salts thereof, as well as processes for preparing these compounds and medicaments containing them. Also disclosed are novel interme...	04/09/2002
6339083	Multiheterocyclic pharmAceuticals The present invention relates to compounds of the general formula (I): ##STR1## and their preparation and use for the production of pharmaceuticals, and pharmaceuticals comprising these compounds....	01/15/2002
6159964	Vitronectin receptor antagonists Compounds of formula (I) are disclosed, wherein: A is a fibrinogen antagonist template; W is a linking moiety of the form --(CHRg)a --U--(CHRg)b --V--; Q1, Q2, Q3 and Q4 ar...	12/12/2000
6117866	Bicyclic fibrinogen antagonists Certain compounds within formula (I) are inhibitors of platelet aggregation: ##STR1## wherein A1 is NH or CH2 ; R is H, C1-6 alkyl, benzyl or a carboxy protecting group; R3 is C1-6 alkyl, Ar-C0-6...	09/12/2000
6100254	Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki...	08/08/2000
6008214	Bicyclic compounds This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation and bone resorption, pharmaceutical compositions for effecting such activity, and a me...	12/28/1999
5674865	Nonpeptidyl integrin inhibitors having specificity for the GPII_b III_a A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t...	10/07/1997
5674863	Nonpeptidyl integrin inhibitors having specificity for the GPII_b III_a receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t...	10/07/1997
5662911	Benzodiazepine protein conjugates Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group, R3 is a halogen, NO2 or NH2, X is hydrogen or a halogen, wherein R is ...	09/02/1997
5565449	Nonpeptidyl integrin inhibitors having specificity for the GPII_b III_a receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t...	10/15/1996
5556990	Polyarylcarbamoylaza- and -carbamoylalkanedioic acids This invention relates to a class of novel dicarboxy amide derivatives of lipophilic amines which exhibit squalene synthase inhibition properties. More specifically the compounds are bis-aryl and/or heteroaryl alkyl or cycloalkylamino dicarboxy amides. Co...	09/17/1996
5468854	Characterization of specific drug receptors with fluorescent ligands Conjugates of fluorescent labels with specific, selective, and high affinity ligands for receptors have been synthesized and used to directly measure binding to receptors. In the examples, fluorescein conjugates of the high-affinity benzodiazepine recepto...	11/21/1995
5324726	Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## wherein: R3 is ##STR2## --NH(CH2)2 --3 NHCOR7, ##STR3## or --X11 NR18 SO2 (CH2)q...	06/28/1994
5302715	Benzodiazepine derivatives The present invention is directed to novel benzodiazepine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the benzodiazepine metabolites. The resulting ...	04/12/1994
5250679	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPII_b III.sub. receptor A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPIIb IIIa receptor and is provided in therapeutic compositions for t...	10/05/1993
5175159	3-substituted-1,4-benzodiazepines as oxytocin antagonists Compounds of Formula I are antagonists of oxytocin and are useful in the treatment of preterm labor and dysmenorrhea, and for stoppage of labor prepatory to Caesarean delivery. ##STR1##...	12/29/1992
5013836	Process for methylating a hindered nitrogen atom in a polysubstituted diazacycloalkan-2-one The difficulty of methylating a hindered piperidinyl, piperazinyl, or diazepinyl group with an Eschweiler-Clarke ("E-C") procedure without using a large molar excess (more than double) of formaldehyde is surprisingly found to be non-existent in the case o...	05/07/1991
4929269	Herbicidal sulfonomides Compounds of the formula ##STR1## and salts thereof, W and W, being independently O and S, A being a nitrogen-containing heterocyclic ring system, E being O, S(O)m or NR3 where m is 0-2, R1, R2 and R3 is hy...	05/29/1990
4820834	Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK)....	04/11/1989
4764512	Benzodiazinone-pyridone compounds, cardiotonic compositions including the same, and their uses This invention relates to substituted benzodiazinone-pyridone compounds and their use as cardiotonic agents including methods for increasing cardiac contractility, pharmaceutical compositions including the same and methods for the preparation thereof....	08/16/1988
4656026	Magnetic resonance (MR) image enhancement compounds for specific areas of the brain An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compoun...	04/07/1987
4377522	Benzodiazepine derivatives There are presented novel benzodiazepine derivatives of the formula ##STR1## wherein R1 is lower alkyl, lower hydroxyalkyl or lower dialkylaminoalkyl, R2 and R3 each are lower alkyl, R4 is halogen, R5	03/22/1983
4346087	Antibacterial surface active agent containing azaalkenelactam An antibacterial surface active agent comprising an effective amount of at least one cyclic amide represented by the general formula ##STR1## wherein R is an alkyl group, alkenyl group, alkylaryl group, alkylarylalkyl group, hydroxyalkyl group, acyl ...	08/24/1982
4079053	Benzodiazepine derivatives Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R2 is a ...	03/14/1978
4010154	Benzodiazepinones Novel 1-substituted benzodiazepine derivatives and salt thereof having the formula, ##STR1## wherein R1 is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a lower alkoxy group or a trifluoromethyl group; R2 is a ...	03/01/1977
3991048	Process for the preparation of 1,4-benzodiazepine derivatives A 1,4-benzodiazepine derivative, or a pharmaceutically acceptable acid salt thereof, of the formula, ##SPC1## Wherein R1 is hydrogen, halogen, nitro or trifluoromethyl; R2 and R3 are independently hydrogen, halogen, lower ...	11/09/1976
3989681	7-Azoxy substituted-1,4-benzodiazepin-2-ones Novel 1,4-benzodiazepin-2-ones of the formula ##SPC1## Wherein R1 is selected from the group consisting of hydrogen, lower alkyl, cycloalkyl-lower alkyl, hydroxylower alkyl, lower alkoxy-lower alkyl and di-lower alkylamino-lower alkyl; R2	11/02/1976
3989829	1,4-Benzodiazepines Benzodiazepine derivatives of the formula, ##SPC1## Wherein R1 is a C2-4 alkenyl group, R2 is a halogen atom and R3 is a hydrogen or halogen atom, which are useful as minor tranquilizer and anticonvulsant. These...	11/02/1976
3970645	1,4-Benzodiazepine derivative The invention relates to new 1,4-benzodiazepine derivatives of the formula ##SPC1## Wherein R1 is hydrogen, halogen, or the trifluoromethyl group, R2 and R3 are alkyl groups, and n is an integer from 1 to 4, and acid addit...	07/20/1976
3954838	Process for preparing alkyl (n-phenylsulfonyloxy) carbamates 1,4-Benzodiazepin-2-ones bearing an acylamidoalkyl-substituent in the 1-position and methods for the preparation thereof are disclosed. These 1,4-benzodiazepin-2-ones exhibit sedative, anti-convulsant and muscle relaxant activity....	05/04/1976

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Class 540/512 - Chalcogen attached indirectly to nitrogen of the hetero ring by acyclic nonionic bonding