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| Number | Title | Issue Date |
| 6307045 | Process for producing halogenated benzene compound The present invention provides a process for producing halogenated benzene compounds. In the process, an organometallic compound represented by the general formula [I]: ##STR1## wherein M represents an R13 Sn group, an R13 | 10/23/2001 |
| 6232308 | Bezazepine derivatives as v integrin receptor antagonists The present invention relates to benzazepine derivatives and their use as v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors v댣, v댥, and/o... | 05/15/2001 |
| 6100254 | Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki... | 08/08/2000 |
| 6015791 | Serine protease inhibitors-cycloheptane derivatives The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compoun... | 01/18/2000 |
| 5580979 | Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions The present invention makes available novel compounds represented by the general formula ##STR1## wherein Y represents a phosphate analog. Which compounds are useful for inhibiting an interaction between a protein containing an SH2 domain and a ... | 12/03/1996 |
| 5312625 | Fused 7-membered cyclic compound and antipsychotic preparation containing the same A therapeutically effective antipsychotic preparation comprising a fused cyclic compound for the treatment of diseases involving the serotonergic pathway having the formula (I) or salts thereof: ##STR1## wherein both of A and B are carbonyl groups, o... | 05/17/1994 |
| 4775671 | Imidazodiazepines There is presented compounds of the formula ##STR1## wherein A together with the two carbon atoms denoted by and ଲ signifies one of the groups ##STR2## and the dotted line signifies the double bond present in cases (1), (2) an... | 10/04/1988 |
| 4405516 | Benzodiazepine derivatives There is provided imidazodiazepines of the formula ##STR1## wherein R1 is methyl, ethyl or isopropyl, one of R4 and R5 is hydrogen and the other is nitro or cyano, and either R2 is hydrogen and R3 | 09/20/1983 |
| 4382891 | Use of fluoroalkoxysulfur fluorides in fluorinations Fluoroalkoxysulfur fluorides of the formula ##STR1## wherein R is H, CH3, CF3, or C2 F5, and n is 1 or 2, used as fluorinating agents to replace OH groups in organic molecules with F and halocarbon solution... | 05/10/1983 |
| 4359420 | Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as and ଲ is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) a... | 11/16/1982 |
| 4316839 | Imidazodiazepine derivatives Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as and ଲ is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) a... | 02/23/1982 |
| 4311651 | Fluoroalkoxysulfur fluorides Fluoroalkoxysulfur fluorides of the formula ##STR1## wherein R is H, CH3, CF3, or C2 F5, and n is 1 or 2; their preparation by reaction of lithium fluoroalkoxides with sulfur tetrafluoride; their use as flu... | 01/19/1982 |
| 4258187 | Process for preparing quinazolinone oxides Improved process for the preparation of 6-substituted-4-phenylquinazolinone 3-oxides. Such compounds are useful as intermediates in the preparation of 3-fluorobenzodiazepines, which are useful as tranquilizers, muscle relaxants and sedatives.... | 03/24/1981 |
| 4246270 | 3-Fluorobenzodiazepines and compositions and uses thereof 3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one , useful as tranquilizers, muscle relaxants, and sedatives.... | 01/20/1981 |
| 4232016 | 3-Fluorobenzodiazepines 3-Fluoro-2,3-dihydro-1H-1,4-benzodiazepin-2-ones of the formula ##STR1## wherein R1 is H, alkyl or fluorinated alkyl of 1-4 carbon atoms and up to 9 fluorine atoms or cycloalkylalkyl of 4-8 carbon atoms; R2 is phenyl; monohaloph... | 11/04/1980 |
| 4215044 | Synthesis of -fluorocarbonyl compounds Process for preparing an organic compound of the formula R2 R2 CFC(O)R3, which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF... | 07/29/1980 |
| 4182760 | Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents N-Fluorohaloacetyl-N-methylaminobenzophenone anti-oxime, the corresponding diazepin-N-oxides, their use as tranquilizers, muscle relaxants and sedatives, and their use as intermediates in the preparation of 3-fluorobenzodiazepines, which are also useful a... | 01/08/1980 |
| 4160092 | Quinazolinone oxides and their use as intermediates for pharmaceutical agents 1-Methyl-6-substituted-4-phenyl-quinazolin-2-one-3-oxides and their use as intermediates in the preparation of 3-fluorobenzodiazepines which are useful as tranquilizers, muscle relaxants and sedatives.... | 07/03/1979 |
| 4141895 | Hydroxyquinazolines and their use as intermediates for pharmaceutical agents 6-Substituted-2-halofluoromethyl-1,2-dihydro-2-hydroxy-1-methyl-4-phenylqui nazolines and their use as intermediates in the preparation of 3-fluorobenzodiazepines, which are useful as tranquilizers, muscle relaxants and sedatives.... | 02/27/1979 |
| 4133809 | 4H-S-Triazolo[4,3-2][1,5]benzodiazepin-5-ones Compounds of the following formula ##STR1## are useful as central nervous system depressants, tranquilizers, sedatives, growth promotors, anti-convulsants and muscle relaxants in mammalian species.... | 01/09/1979 |
| 4120856 | Process for the preparation of 3-fluorobenzodiazepines 3-Fluorobenzodiazepines, such as 3-fluoro-1,3-dihydro-1-methyl-7-chloro-5-phenyl-2H-1,4-benzodiazepin-2-one , useful as tranquilizers, muscle relaxants, and sedatives.... | 10/17/1978 |
