Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7507815 | Succinoylamino lactams as inhibitors of a-β protein production This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-pe... | 03/24/2009 |
| 7456278 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifica... | 11/25/2008 |
| 7390801 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/... | 06/24/2008 |
| 7375101 | Benzodiazepine derivatives, preparation thereof and use thereof Compounds of Formula (I) wherein R1, R3, R4, R5 and X are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in ther... | 05/20/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7358239 | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein -Z1-Z2- is... | 04/15/2008 |
| 7304055 | Succinoylamino lactams as inhibitors of Aβ protein production This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-pe... | 12/04/2007 |
| 7276496 | Cyclic malonamides as inhibitors of Aβ protein protection This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor prote... | 10/02/2007 |
| 7276348 | Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 10/02/2007 |
| 7250410 | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis... | 07/31/2007 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7205293 | Benodiazepine spirohydantoin CGRP receptor antagonists The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pha... | 04/17/2007 |
| 7196079 | Benzodiazepine CGRP receptor antagonists The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonis... | 03/27/2007 |
| 7186712 | Compositions and methods relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 03/06/2007 |
| 7160880 | Short-acting benzodiazepines The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy. ... | 01/09/2007 |
| 7144880 | Compositions relating to novel compounds and targets thereof The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat... | 12/05/2006 |
| 7115598 | Substituted 1,4-diazepines and uses thereof The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharm... | 10/03/2006 |
| 7105509 | Benzodiazepine derivatives as APP modulators A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by γ-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of β-amyloi... | 09/12/2006 |
| 7053084 | Succinoylamino benzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 05/30/2006 |
| 6995155 | Benzodiazepine derivatives as inhibitors of gamma secretase Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease. ... | 02/07/2006 |
| 6960576 | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more spec... | 11/01/2005 |
| 6900222 | Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein —Z1—Z2 | 05/31/2005 |
| 6825191 | Benzodiazepine derivatives The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. The... | 11/30/2004 |
| 6759404 | Cyclic malonamides as inhibitors of aβ protein production Novel cyclic malonamides having the formula (I): and their pharmaceutical compositions. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-pept... | 07/06/2004 |
| 6756511 | Gamma-secretase inhibitors Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors. | 06/29/2004 |
| 6713476 | Substituted cycloalkyls as inhibitors of a beta protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specif... | 03/30/2004 |
| 6632812 | Substituted lactams as inhibitors of Aଲ protein production This invention relates to novel lactams of Formula (I): ##STR1## having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifical... | 10/14/2003 |
| 6569851 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ଲ-amyloid peptide release and/or its synthesis by use of such compounds Disclosed are compounds which inhibit ଲ-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits ଲ-amylo... | 05/27/2003 |
| 6552041 | Cyclized amide derivatives The present invention relates to cyclized amide derivatives of formula (I) ##STR1## These cyclized amide derivatives are useful for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comp... | 04/22/2003 |
| 6509333 | Lactams substituted by cyclic succinates as inhibitors of Aଲ protein production This invention relates to novel lactams having the Formula (I): ##STR1## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the produc... | 01/21/2003 |
| 6503901 | Amino lactam sulfonamides as inhibitors of Aଲ protein production This invention relates to novel lactams having the Formula (I): ##STR1## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the produc... | 01/07/2003 |
| 6503902 | Hydroxyalkanoylaminolactams and related structures as inhibitors of a ଲ protein production This invention relates to novel lactams having the formula (I): ##STR1## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the produc... | 01/07/2003 |
| 6462037 | 1,4-benzodiazepin-2-ones useful as HIV reverse transcriptase inhibitors The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I): ##STR1## or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pha... | 10/08/2002 |
| 6333321 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 12/25/2001 |
| 6329365 | Inhibitors of interleukin-1ଲ converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1ଲ converting enzyme ("ICE"). This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical com... | 12/11/2001 |
| 6291452 | 1,4-benzodiazepinones and their uses as CCK antagonists Benzodiazepine derivatives of the formula: ##STR1## wherein R2 is alkyl or cycloalkyl-alkyl when R4 is hydrogen, or R2 is a variety of specified groups when R4 is alkyl, halogen or dialkylamino, are useful as ch... | 09/18/2001 |
| 6232308 | Bezazepine derivatives as v integrin receptor antagonists The present invention relates to benzazepine derivatives and their use as v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors v댣, v댥, and/o... | 05/15/2001 |
| 6214823 | Benzodiazepine derivatives as antiarrhythmic agents This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.... | 04/10/2001 |
| 6121258 | 1,5-heterocyclic metalloprotease inhibitors The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibito... | 09/19/2000 |
| 6100254 | Inhibitors of protein tyrosine kinases Disclosed herein are small molecule, non-peptidyl inhibitors of protein tyrosine kinases, and methods for their use. The instant inhibitors are based on a 1,4-benzodiazepin-2-one nucleus. Methods are provided for inhibition of specific protein tyrosine ki... | 08/08/2000 |
