|8003783||17B-hydroxysteroid dehydrogenase inhibitors|
There is provided a compound of Formula (III) wherein R1 is a selected from an alkyloxyalkyl group, a nitrile group, alkylaryl group, alkenylaryl group, alkylheteroaryl group, alkenylheteroaryl group...
|7074779||Estrieno[3,2-b]/[3,4-c]pyrrole derivatives useful as modulators of the estrogen receptors|
The present invention is directed to novel estrieno[3,2-b]/[3,4-c]pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor. ...
|7053076||Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs|
Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administration to provide for enhanced t...
|5510340||Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use|
Novel antihypercholesterolemic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R is a C-17 side chain, R1 is --OH, .dbd.O, or the like, and X and Y are N, N.fwdarw.O, CH, C--OH, C--OCH
This invention refers to compounds of formula (I) ##STR1## wherein x, y, z represent single or double bonds; R is hydrogen or C1 -C4 alkyl; R1 is hydrogen or an acyl group; R2 is hydrogen; C1 -C4
|5126488||2ଲ,19-methyleneamino bridged steroids as aromatase inhibitors|
The present invention is directed to 2ଲ,19-(methyleneamino)androst-4-ene-3,17-dione which has the formula ##STR1## and the corresponding 17ଲ-ol which are useful as aromatase inhibitors. The compounds are prepared by the cyclization of an ...