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| Number | Title | Issue Date |
| 7511135 | Method for manufacture of ceftiofur A process for preparation of ceftiofur of formula (I) having purity greater than 97% is disclosed. The process comprises reacting [2-(2-aminothiazol-4-yl)]-2-syn-methoxyimino acetic acid-2-benzothiazolyl thioester of formul... | 03/31/2009 |
| 7459550 | Process for the preparation of Cefditoren The present invention relates to an improved process for the preparation of Cefditoren of formula (I), the said process comprising the steps of: i) converting the compound of formula (II) to a compound of the formula (III) using TPP and sodium iodide in the presence... | 12/02/2008 |
| 7396926 | Beta-lactamase substrates having phenolic ethers Provided are fluorescent substrates for β-lactamases having the general formula I: in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R′ is selected from the group consisting of H, physiologically acceptable ... | 07/08/2008 |
| 7384928 | Broad spectrum cephem compounds A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut... | 06/10/2008 |
| 7339055 | Process for the preparation of cephalosporin antibiotic A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent | 03/04/2008 |
| 7335767 | Method for preparation of ceftiofur and salts thereof A process for preparation of ceftiofur sodium of formula (Ib) possessing high stability and having purity of more than 97% and substantially free of impurities, is disclosed. The process comprises: i) reacting cef... | 02/26/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7244748 | Pyridines for treating injured mammalian nerve tissue The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, composi... | 07/17/2007 |
| 7244842 | Amorphous hydrate of a cephalosporin antibiotic A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a terti... | 07/17/2007 |
| 7098329 | Process for the preparation of a cephalosporin antibiotic An improved process for the preparation of ceftriaxone sodium comprising the steps of: i) reacting the 3-cephem derivative of formula (II) with halo acid derivative of formula (III)... | 08/29/2006 |
| 7071330 | Process for carbapenem synthesis A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed. ... | 07/04/2006 |
| 7071329 | Process for preparing cephalosporins with salified intermediate Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein: Z is benzathine; and X and R2 are as defined in the spec... | 07/04/2006 |
| 6919449 | Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one... | 07/19/2005 |
| 6916801 | 7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β... | 07/12/2005 |
| 6913748 | Cross-linkers with high reactivity and solubility and their use in the preparation of conjugates for targeted delivery of small molecule drugs Disclosed is a method of making conjugates of cell binding agents and small molecule drugs comprising reacting a cell binding agent with a bifunctional cross-linking moiety to thereby provide the cell binding agent with a reactive disulfide group and then reacting t... | 07/05/2005 |
| 6906187 | Manufacture of cefalosporins and intermediates There is described a process for the preparation of 3-disubstituted cepham-4-carboxylic acid derivatives of formula I wherein R″ is 4-methoxybenzyl, X is the residue of a thioether and Z is a residue of a nucleophili... | 06/14/2005 |
| 6800756 | Method for the preparation of ceftiofur sodium and its intermediates The present invention relates to preparation of Ceftiofur acid of formula (I), and its pharmaceutically acceptable salts. The process includes the steps of (i) condensing an activated derivative of | 10/05/2004 |
| 6787649 | Cephalosporin intermediates A process which comprises (i) acylating a compound of formula II with a compound of formula IV to obtain a compound of formula I ... | 09/07/2004 |
| 6777549 | β-lactam production A process for the production of a compound of formula comprising i) silylating a compound of formula then reacting a resulting with a compound of formula | 08/17/2004 |
| 6723716 | 7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1 is selected from the group consisting of hydrogen and —C(O)CH(... | 04/20/2004 |
| 6713625 | Process for the preparation of cefditoren using the thioester of thiazolylacetic acid The present invention provides a process for the preparation of Cefditoren of the formula (I) which comprises acylating 7-amino-cephem carboxylic acids of the general formula (IV) | 03/30/2004 |
| 6642377 | Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: ##STR1## wherein the ring A means the basic antibiotic; R10 means a protected func... | 11/04/2003 |
| 6610845 | Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds The present invention provides new thioester derivatives of thiazolyl acetic acid of the general formula (I), ##STR1## wherein, R1 represents H, trityl, CH3, CRa Rb COOR2 (Ra and R... | 08/26/2003 |
| 6583133 | Propenyl cephalosporin derivatives and process for the manufacture thereof Disclosed are cephalosporin derivatives of the general formula ##STR1## wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and consisting of carbon, hydrogen, and optional oxygen, sulfu... | 06/24/2003 |
| 6576761 | Process for the preparation of cephem compounds 1. A process for preparing a 3-alkenylcephem compound or 3-norcephem compound of the formula (3) characterized in that an alkenyl halide of the formula (2), a nickel catalyst, a metal up to -0.3 (V/SCE) in standard oxidation reduction potential and a comp... | 06/10/2003 |
| 6555679 | Method for preparation of ceftiofur sodium from its hydrohalide salts The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.... | 04/29/2003 |
| 6555680 | Method for the preparation of ceftiofur sodium The present invention relates to a process for the preparation of sodium salt of Ceftiofur as given in Formula I, directly from its amine salt using sodium base. ##STR1##... | 04/29/2003 |
| 6552186 | ଲ-lactam production ##STR1## The present invention provides processes for the production of a compound of formula I wherein X, R1 and R2 are substituents conventional in cephalosporin chemistry; especially a compound of formula I is ceftrixone, cefotaxime; e.g., in the form ... | 04/22/2003 |
| 6504026 | Process for production of ceftiofur Process for preparing ceftiofur having formula I: ##STR1## in the form of the sodium salt.... | 01/07/2003 |
| 6468995 | Cephem compounds A compound of the formula: ##STR1## wherein R1 is amino or protected amino; R2 is hydrogen, lower alkyl or hydroxy protective group; R3 is carboxy or protected carboxy; R4 is an unsubstituted 5, 6 or 7-membered heteromono... | 10/22/2002 |
| 6458949 | Ceftiofur, its intermediate and a process for the preparation of the same A novel process for the preparation of ceftiofur, a cephalosporin antibiotic useful in the treatment of bovine respiratory disease using a novel bromo or chloro intermediate. the process comprises of the steps of cyclizing a new bromo or chloro intermedia... | 10/01/2002 |
| 6441162 | Crystalline substance of cefditoren pivoxyl and the production of the same A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren p... | 08/27/2002 |
| 6437119 | Compounds formed from two or three antibiotics and their processes of preparation Processes for preparing compounds having two or three antibiotic functionalities using quinolone derivatives, ଲ-lactams and vancomycin and the like as the starting materials and chloride linking agents; and the novel compounds prepared by these proc... | 08/20/2002 |
| 6417175 | Phosphonocephem derivatives, process for the preparation of the same, and use thereof A novel cephem compound of the formula: ##STR1## wherein R1 is a phosphono group or a group convertible to a phosphono group; R2 is a hydrogen atom or a group having a linkage through a carbon atom; each of Q and X is a nitrogen atom... | 07/09/2002 |
| 6388070 | Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds The present invention provides novel thioester derivatives of thiazolyl acetic acid of the general formula (I), ##STR1## wherein, R1 represents H, trityl, CH3, or CRa Rb COOR3, in which Ra ... | 05/14/2002 |
| 6384215 | Preparation of new intermediates and their use in manufacturing of cephalosporin compounds The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said thioester derivatives can be prepared by reacting 4-halogeno-... | 05/07/2002 |
| 6303592 | 7-alkylidene cephalosporanic acid derivatives and methods of using the same Derivatives of 7-alkylidene cephalosporanic acid sulfone and the pharmaceutically active salts thereof are found to be potent inhibitors of ଲ-lactamase enzymes.... | 10/16/2001 |
| 6294527 | Cephem compounds An antibacterial compound ##STR1## wherein ##STR2## represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting atom), there being no R4 where ##STR3#... | 09/25/2001 |
| 6294669 | Crystalline substance of cefditoren pivoxyl and the production of the same As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving... | 09/25/2001 |
| 6294668 | Vinylpyrrolidinone cephalosporin derivatives The present invention relates to cephalosporin derivatives of the general formula ##STR1## where R.sup.1 is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl, phenyl, benzyl, styryl, naphthyl and heterocyclyl bei... | 09/25/2001 |
