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| Number | Title | Issue Date |
| 8058425 | Purine derivatives as kinase inhibitors The present invention provides kinase inhibitors of Formula I. ... | 11/15/2011 |
| 7893254 | Process for production of 3-alkenylcephem compounds A process for preparing 7-amino-3-[(E/Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-carboxylic acid of the formula (1) and an alkali metal salt thereof, said acid and said salt being improved in the content of 7-amino-3-[(Z)-2-(4-methylthiazol-5-yl)vinyl]-3-cephem-4-... | 02/22/2011 |
| 7759483 | 3-alkenylcephem compounds and process for production thereof A 3-alkenylcephem compound of the formula (1) wherein R1 is benzyl or phenoxymethyl, R2, R3 and R4 are alike or different and are each a hydrogen atom, C1-10 alkyl, C | 07/20/2010 |
| 7560545 | Process for obtaining cefotetan with high yield The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Al3+ ions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which... | 07/14/2009 |
| 7507813 | Amorphous cefuroxime axetil and preparation process therefore A novel process for the preparation of amorphous cefuroxime axetil particles and the amorphous cefuroxime axetil particles therefrom are disclosed in the invention. Specifically, the invention is implemented by means of antisolvent recrystallization to prepare the c... | 03/24/2009 |
| 7351419 | Oral pharmaceutical suspension of Cefdinir crystal The present invention relates to a novel oral pharmaceutical suspension of Cefdinir crystal. More specifically, the present invention relates to a novel kit for preparation of an oral pharmaceutical suspension containing crystal form C Cefdinir. ... | 04/01/2008 |
| 7244842 | Amorphous hydrate of a cephalosporin antibiotic A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a terti... | 07/17/2007 |
| 7241813 | End-capped polymers and compositions containing such compounds End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula: and may be combin... | 07/10/2007 |
| 7173126 | Crystalline cefdinir salts Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obt... | 02/06/2007 |
| 7045618 | Cefpodixime proxetil The present invention relates to an improved and cost effective process for the industrial manufacture of cefpodoxime proxetil. More specifically, the present invention relates to the preparation of cefpodoxime proxetil of high purity and yield. The process comprise... | 05/16/2006 |
| 7034162 | Amorphous form of 3-[2-(dimethylamino) ethyl]-N-methyl-1H-indole-5-methane sulfonamide succinate (sumatriptan succinate) The present invention relates to an amorphous form of Sumatriptan succinate of Formula (1). The present invention also relates to process for the preparation of an amorphous form of Sumatriptan succinate. The process for the preparation of an amorphous form o... | 04/25/2006 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6949641 | Crystalline β-lactam intermediate The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1 -(isopropoxy/crystallization of cefpodoxime proxetil. The crystallization process comprises dissolving or suspend... | 09/27/2005 |
| 6835829 | Purification process Processes for the depletion of 7-ADCA in mixtures of vinyl-ACA with 7-ADCA via novel salts of vinyl-ACA or via chromatography. ... | 12/28/2004 |
| 6803460 | Process for the fermentative production of cephalosporin A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R2 is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-carboxyethyithio)acetyl, ... | 10/12/2004 |
| 6602999 | Amorphous form of cefpodoxime proxetil A novel process for the production of an improved amorphous form of cefpodoxime proxetil [(6R-[6,7ଲ(Z))]-7-{E(2-Amino-4-thiazolyl)(methoxyimino)acetyl] amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2. 0]oct-2-ene-2-carboxylic acid-... | 08/05/2003 |
| 6552185 | Process for the fermentative production of cephalosporin A method for the recovery of a compound formula (I) from a complex mixture, ##STR1## comprising the steps of: (a) acidifying the complex mixture to a pH below 6.5 and maintaining the mixture below said pH at a temperature of between 50° C. and 130° C.; ... | 04/22/2003 |
| 6504026 | Process for production of ceftiofur Process for preparing ceftiofur having formula I: ##STR1## in the form of the sodium salt.... | 01/07/2003 |
| 6489470 | Process for the preparation of cefpodoxime proxetil diastereoisomers A process for increasing the diastereoisomeric ratio (B/A+B), wherein B is the more apolar and A is the more polar of two diastereoisomers, of a mixture of diastereoisomers of a compound of formula ##STR1## the diastereoisomers being with respect to the c... | 12/03/2002 |
| 6350869 | Crystalline amine salt of cefdinir Cefdinir in the form of a salt with dicyclohexylamine, a process for its production and its use in the purification of impure cefdinir.... | 02/26/2002 |
| 6288223 | Process for the selective preparation of Z-isomers of 3-2(substituted vinyl)cephalosporins There can be produced, at a high selectivity and in a high yield, the Z-isomer of a 7-N-unsubstituted or substituted-amino-3-[2-(4-substituted or unsubstituted-thiazol-5-yl) vinyl]-3-cephem-4-carboxylic acid or an ester thereof having the general formula ... | 09/11/2001 |
| 6284888 | Vinyl-ACA purification process A process for purification of vinyl-ACA of formula ##STR1## from a mixture of vinyl-ACA and 7-ADCA of formula ##STR2## is provided. The process comprises a) producing a mixture of a salt of vinyl-ACA and a salt of 7-ADCA in a solvent in which the salt of ... | 09/04/2001 |
| 6172221 | Clavulanic acid extraction process A back extraction process in which beta-lactam antibiotics or clavulanic acid is extracted from an organic solvent phase into an aqeous medium phase, using a mixing region in which the phases are mixed rapidly under high turbulence and shear stress.... | 01/09/2001 |
| 6100393 | Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes Process for purifying 7-substituted aminodeacetoxycephalosporins through the use of filter membranes. A process for purification by ultrafiltration and/or nanofiltration with a cut-off for molecular weights over 10,000 Dalton and preferably over 2000 Dalt... | 08/08/2000 |
| 5874571 | Process for the recovery of cephalexin The disclosed process is for the recovery of cephalexin from a mixture containing cephalexin and 7-aminodesacetoxy cephalosporanic acid (7-ADCA), wherein a mixture of cephalexin and 7-ADCA, with a pH higher than 7, which apart from any solid cephalexin be... | 02/23/1999 |
| 5693790 | Crystalline form of a cephalosporin antibiotic The preparation of a novel crystalline cefaclor and the conversion of such a product to cefaclor monohydrate are described. The new intermediate cefaclor is a particular crystalline form and possesses the same antibiotic properties as cefaclor monohydrate... | 12/02/1997 |
| 5686588 | Amine acid salt compounds and process for the production thereof A stoichiometric acid moiety transfer reaction for the preparation of an acid salt of an amine compound is disclosed. The acid moiety transfer reaction provides amine acid salts of high purity and having crystalline structure of uniform size and shape.... | 11/11/1997 |
| 5589593 | Crystalline form of a cephalosporin antibiotic The preparation of a novel crystalline cefaclor and the conversion of such a product to cefaclor monohydrate are described. The new intermediate cefaclor is a particular crystalline form and possesses the same antibiotic properties as cefaclor monohydrate... | 12/31/1996 |
| 4973685 | Heteroannellated phenylglycine-ଲ-lactam antibiotics Heteroannellated penicillins and cephalosporins of the formula ##STR1## in which R1 --stands for a radical of the formula ##STR2##... | 11/27/1990 |
| 4820833 | Preparation of a highly pure, substantially amorphous form of cefuroxime axetil There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of... | 04/11/1989 |
| 4775751 | Process for cephalexin hydrochloride alcoholates The crystalline ethanol or methanol solvates of cephalexin hydrochloride are isolated in high yield from solutions of cephalexin hydrochloride in substantially anhydrous ethanol or methanol, respectively, by adding miscible C5 -C6 al... | 10/04/1988 |
| 4727070 | 3-Propenzl cephalosporin isomer separation process and derivative The antibiotic 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]-3-[(Z)-1-propenyl]ceph-3-em-4-c arboxylic acid (BMY-28100) forms imidazolidinone derivatives on reaction with ketones. These derivatives are useful in pharmaceutical dosage forms and as interme... | 02/23/1988 |
| 4719287 | Higher alkyl pyrrolidone extractants for water soluble phenolic or carboxylic antibiotics The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N--C8 --C14 alkyl pyrrolidone extractant and the process involving the extraction of said an... | 01/12/1988 |
| 4684641 | 7-hydroxyaminocephalosporin antibiotics 7-Hydroxyamino-7ଲ-[2-substituted-2-(acylamino)acetamido]-cephal osporin antibiotics, pharmaceutically-acceptable salts and in vivo hydrolyzable esters thereof, a method of treating susceptible infections therewith, and intermediates therefor.... | 08/04/1987 |
| 4668782 | Anhydrous crystalline or crystalline hemihydrate monohydrate or trihydrate of cephalosporin derivative An anhydrous crystalline, or crystalline hemihydrate, monohydrate or trihydrate of cephalosporin derivative of (6R,7R)-7-[(Z)-2-(2-aminothiazole-4-yl)-2-methoxy-iminoacetoamido]-3(1-qui nuclidiniummethyl)-3-cephem-4-carboxylate. These crystalline materials... | 05/26/1987 |
| 4594417 | Crystalline antibiotic salt Crystalline cephalosporin hydrochloride salt represented by the formula ##STR1## wherein the oxime is in the syn configuration, is a useful pharmaceutical form of, and tool for purification of, the corresponding antibiotic free base; processes for it... | 06/10/1986 |
| 4581166 | Method for isolating and purifying antibiotics A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0° to 40° C. and at a pressure which lies between the critical pressure and ... | 04/08/1986 |
| 4560749 | Cephem-3-imidates and 3-amidines 3-Azido-3-cephem esters are reacted with electron rich olefins, e.g., enamines and cyclic enol ethers, to provide C3 amidines and imidates having antibacterial activity in the free acid form. For example, 3-azido-3-cephem esters react with ethy... | 12/24/1985 |
| 4535155 | Method for separating cephalosporins The interseparating of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a fractional elution thereof with water containing 0 to 20 p... | 08/13/1985 |
| 4477659 | Cephalosporin compound A cephalosporin compound of the general formula (I): ##STR1## wherein X is a hydrogen atom, a chlorine atom, a methyl group, a methoxy group, an acetoxymethyl group or --CH2 SHet wherein Het is a 5- or 6-membered heterocyclic ring containi... | 10/16/1984 |
