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Class 540/2 - Cyclopentanohydrophenanthrene ring system containing


Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds which additionally contain the cyclopentanohydrophenanthrene
No. of patents: 33
Last issue date: 07/29/2008


NumberTitleIssue Date
7405206Anti-inflammatory androstane derivatives
There are provided compounds of formula (I) wherein R1 represents O, S or NH; R2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R3 represents hyd...
07/29/2008
7405207Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily acceptable carrier or diluent, and having a particle size of about 0.1 ...
07/29/2008
7381566Method for preparing organic nanotubules of lithocholic acid, nanotubules derived therefrom, and uses thereof
A method for preparing organic nanotubules in an aqueous medium including preparing a basic solution with a pH from 10 to 14, adding an organic compound of the formula: wherein R1 is a C17-C20
06/03/2008
7229980Paroxetine cholate or cholic acid derivative salts, and composition comprising paroxetine and cholic acid or derivative thereof
Disclosed herein is a paroxetine cholate or cholic acid derivative salt and a composition comprising paroxetine and cholic acid or a derivative thereof. Further disclosed is a pharmaceutical composition comprising the paroxetine salt or the composition. The pharmace...
06/12/2007
7041839Steroidal antiestrogens and antiandrogens and uses thereof
The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorde. In a...
05/09/2006
6921757Organic compounds
Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals ...
07/26/2005
6670348Methods and compositions for destruction of selected proteins
Compounds having an ansamycin anitibiotic, or other moiety which binds to hsp90, coupled to a targeting moiety which binds specifically to a protein, receptor or marker can provide effective targeted delivery of the ansamycin antibiotic leading to the deg...
12/30/2003
6660725Method and composition for modulating amyloidosis
Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include ...
12/09/2003
659688519-Nor steroids having a thiocarbonated chain in position 11beta, their preparation process and the intermediates of this process, their use as medicaments and compositions
Novel compounds having a formula selected from the group consisting of ##STR1## wherein the substituents are defined as in the specification which are intermediates for the production of vinyl compounds having a remarkable anti-estrogenic and anti-prolife...
07/22/2003
6479063Therapeutic uses of hormonal manipulation using combinations of various agents to treat atherosclerosis
A method of decreasing atherosclerosis and its complications involving administering to a human or animal various combinations of medications with Finasteride, Bicalutamide, Flutamide and Nilutamide....
11/12/2002
6417365Method for recovering medicaments from preparations, and from the precursors or wastes thereof
In a process for recovering medicinal substances or active substances from preparations, their initial products or waste, a flat-shaped starting material in the form of a film with adhesive and an active substance-containing material is provided with one ...
07/09/2002
6369247Process for oxidation of steroidal compounds having allylic groups
The instant invention involves a process for oxidizing compounds containing an allylic group, i.e. those containing an allylic hydrogen or allylic alcohol group, to the corresponding enones, using a ruthenium-based catalyst in the presence of a hydroperox...
04/09/2002
6359113Protective group, compound protected by said group and device for grafting the protective group on the compound to protect it
The protective group having the following formula (I): Ar--L-- (I) wherein Ar represents a substantially planar, fused ring system containing at least 4 aromatic rings, and L represents a group containing at least one carbon atom which is capable of bonding t...
03/19/2002
620096517-Azolyl steroids useful as androgren synthesis inhibitors
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed....
03/13/2001
5990078Means of increasing estrogen receptor levels in neural tissue
This invention provides a method of increasing the level of estrogen receptors in the neural tissue of a subject which comprises administering to the subject estrogen in an amount effective to increase the level of neurotrophin receptors and a neurotrophi...
11/23/1999
5962667Pharmaco-gene delivery in human breast cancer cells
Estradiol facilitates non-viral gene delivery to breast tumor cells. The effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line. Thus, compositions and treatment regimens that use estradiol, or other estrogen ...
10/05/1999
5948925Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with ...
09/07/1999
5869605Protected compound comprising a protective group removably attached to a compound to be protected
The protective group having the following formula (I): Ar--L-- (I) wherein Ar represents a substantially planar, fused ring system containing at least 4 aromatic rings, and L represents a group containing at least ...
02/09/1999
5869652Process for producing active substances from unused or discarded devices for the transdermal administration
In a process for reprocessing devices for the transdermal application of active substances or their process waste, active substance-containing components are brought into solution and the active substances are recovered therefrom....
02/09/1999
584393311ଲ-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents
Compounds of formula I ##STR1## wherein X, R1, R2, R3 and R4 have the meanings indicated in the description, are described, as well as processes for their production, pharmaceutical preparations containing ...
12/01/1998
5843670Carbodiimide group-containing digoxigenin derivatives
As a novel digoxigenin derivative which makes the labeling procedure simple, can be used to label a naturally-occurring nucleic acid, and enables highly sensitive assay, carbodiimide group-containing digoxigenin derivative represented by the following for...
12/01/1998
582467017-deoxycorticosteroid-21-›O!carboxylic esters, processes for their preparation and pharmaceuticals containing these compounds
17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH3 ; R(1) is aryl or hetaryl and R(2) is H or methyl....
10/20/1998
5760025Steroid derivatives for the treatment of prostatic hypertrophy, their preparation and uses
Compounds of formula (I): ##STR1## ›wherein: R1 is hydrogen, alkyl, aryl-substituted alkyl or aromatic heterocyclic-substituted alkyl; R2 is: aryl-substituted alkyl, aromatic heterocyclic-substituted alkyl or diarylamino; and R...
06/02/1998
5578726Process for producing 7 ଲ-substituted-4-aza-5 ଱-androstan-3-ones
Described is a new process for producing 7ଲ-substituted-4-aza-5଱-androstan-3-ones and related compounds which are 5଱-reductase inhibitors, consisting of reducing the corresponding androsteneone with lithium and liquid ammonia, contacting...
11/26/1996
5420120Anti-inflammatory glucocorticoid compounds for topical ophthalmic use
Topically administrable C-21 thioether glucocorticoid steroid derivatives are disclosed as effective anti-inflammatory agents for the treatment of ophthalmic inflammatory disorders. These C-21 thioether derivatives do not cause a significant increase in i...
05/30/1995
5397563Perfluoro-t-butyl-containing steroids for use in fluorine-19 NMR and/or MRI
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellen...
03/14/1995
5278296Production of hydroxysteryl glycoside compounds
Novel glycosides, especially steroidal glycosides, and a novel method of their production, are provided. For the novel method of producing novel glycosides, hydroxysteryl compounds are glycosylated with tri-O-acyl glucal using molecular iodine as a reacti...
01/11/1994
5241070Nucleophilic polysubstituted aryl acridinium esters and uses thereof
This invention is directed to novel nucleophilic polysubstituted aryl acridinium esters and to novel conjugates thereof. The novel nucleophilic polysubstituted aryl acridinium esters and novel conjugates thereof are useful in biological assays, including ...
08/31/1993
5237064Process for producing 7ଲ-substituted-aza-5댚ndrostan-3-ones
Described is a new process for producing 7ଲ-substituted-4-aza-5଱-androstan-3-ones and related compounds which are 5଱-reductase inhibitors....
08/17/1993
5087710Homogeneous rhenium catalysts for metathesis of olefins
The invention pertains to rhenium (VII) compounds which are catalysts for metathesis of ordinary olefins (hydrocarbons) and functionalized olefins in a homogeneous phase and to methods of synthesizing these compounds. The rhenium compounds comprise a rhen...
02/11/1992
5068226Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
Cyclodextrins and especially ionic cyclodextrin derivatives facilitate the iontophoretic delivery of pharmaceutically active agents....
11/26/1991
4701542Resolution of hemiacetals and alcohols
A process for the resolution of hemiacetal compounds of the formula ##STR1## wherein A is a hydrocarbon chain containing 1 to 16 groups, the said chain optionally containing at least one heteroatom, at least one unsaturation, the assembly of the grou...
10/20/1987
3989711Soft quaternary surface active agents exhibiting antibacterial activity
Soft quaternary surface active agents having the formula: ##EQU1## wherein ##EQU2## represents a tertiary open chain or cyclic aliphatic amine; wherein ##EQU3## represents an aromatic amine; wherein R represents a member selected from ...
11/02/1976
 
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