Class 540/105 - Chalcogen bonded directly at the 14-position of the cyclopentanohydrophenanthrene ring system or double bond in the D ring (e.g., cardenolides, etc.)

Subclass of Class 540 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein chalcogen (i.e., oxygen, sulfur, selenium
No. of patents: 26
Last issue date: 06/24/2008

Number	Title	Issue Date
7390803	Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28...	06/24/2008
6306845	Method for treating demyelinating disease The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity neuromodulatory Na,K-ATPase so as to treat the demyelinating diseas...	10/23/2001
6262042	17ଲ-amino and hydroxylamino-11ଲ-arylsteroids and their derivatives having agonist or antagonist hormonal properties The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity....	07/17/2001
5198537	Digoxigenin derivatives and use thereof The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom. The present invention also provides digoxigenin conjuga...	03/30/1993
5003054	Ouabain triacetate derivative compounds A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase mater...	03/26/1991
4847246	Antiviral compositions derived from fireflies and their methods of use This invention relates to antiviral organic steroid compositions and derivatives thereof; a process of producing the antiviral compositions; and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are derived fr...	07/11/1989
4788136	Diagnostic immunoassay by solid phase separation for digoxin A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase mater...	11/29/1988
4380624	Novel isomers of bufalin and resibufogenin and their preparation This invention relates to novel isomers of naturally occurring cardiotonic compounds, specifically novel isobufalins and novel isoresibufogenins. This invention also relates to a novel method of preparing the novel isomers....	04/19/1983
4334069	Chemiluminescent phthalhydrazide-labeled hapten conjugates Chemiluminescent-labeled conjugates of the formula: ##STR1## wherein one of R1 and R2 is hydrogen and the other is --NR3 R4 ; R3 is hydrogen or straight chain alkyl containing 1-4 carbon atoms an...	06/08/1982
4331802	Organometallic reagents and their use in the synthesis of cardenolides and isocardenolides A method for synthesizing a cardenolide or isocardenolide by subjecting an ଱,ଲ-unsaturated steroidal 17-ketone to a double bond shift and hydrogenation to produce a (C/D cisoid) ketone which is treated with an organometallic reagent to yield a...	05/25/1982
4259240	Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom The invention relates to furyl intermediates and the preparation thereof, said intermediates being particularly useful in the preparation of synthetic cardenolides and their isomers. The process provides for the reaction of an unsaturated steroidal 17 ket...	03/31/1981
4255329	Double receptor fluorescent immunoassay A novel sensitive method for determining qualitatively and quantitatively the presence of a wide variety of physiologically active organic compounds (ligand) and their receptors is provided. The method employs a reagent which involves bonding a compound h...	03/10/1981
4230621	Steroid derivatives and their use in radioimmunoassays Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a des-hydroxy steroid moiety of (i) a hydroxy steroid intended for radioimmunoassay or (ii) a hydroxy containing derivative of a steroid intended for radioimmunoassay, said de...	10/28/1980
4218447	Acyl derivatives of hellebrigenin There are prepared compounds corresponding to the general formula: ##STR1## in which R represents a 2,2-dimethylethenyl; isopropyl; nonyl; a C3 -C6 -cycloalkyl radical; a phenyl group substituted by at least one nitro group, or ...	08/19/1980
4175078	Cardenolide and bufadienolide derivatives of ajmaline and process for producing same According to the invention, the novel substances are the cardenolide and adienolide derivatives of ajmaline of the general formula ##STR1## wherein R is cardenolide or bufadienolide of the general formula ##STR2## Z is an unsaturated five-membe...	11/20/1979
4115539	Analytical or clinical derivatives, tagged derivatives and methods of analysis using such derivatives Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form derivatives receptive to tagging, as by radiolabeling. The t...	09/19/1978
4102884	14 ଲ-Hydroxy 3-deoxycardenolides Novel compounds of the formula ##STR1## useful as pharmaceutical compounds are disclosed. Processes are also disclosed for their preparation....	07/25/1978
4097477	Steroid compounds and processes thereof Novel steroids of the formula ##STR1## Also there are provided processes for preparing such compounds. The new compounds are useful as intermediates in the preparation of known cardenolides; various of the compounds have other uses as blocking agents...	06/27/1978
4030886	Saturation analysis The invention provides a method and a kit for the saturation analysis of a steroid characterized by the use of a selenium-75 labelled version of the steroid to be assayed. Selenium-75 derivatives of steroids are quite simple to prepare and have practical ...	06/21/1977
4000125	Novel cardiotonic steroids, process for their preparation and therapeutical use The invention relates to novel steroid compounds having the formula ##STR1## and their glycoside derivatives containing a pyridazine ring, in which particularly the substituent R4 is a hydroxy group or a hexopyranoside unit or a chain of t...	12/28/1976
3981982	Radioimmunoassay for determining the digoxin content of a sample A competitive radioimmunoassay for the measurement of digoxin in a serum sample in which the non-radioactive digoxin competes with a constant amount of a radioactively labeled digoxin tyramine analog comprising 3-O-(4-Hydroxyphenethylcarbamoyl) digoxigeni...	09/21/1976
3954739	Biological reagent Compounds of formula (VIII) wherein R1, r2, r3, r4 and R5 are each selected from hydrogen and an hydroxyl group and at least four are hydrogen; B is an alkylene chain of from 1 to 4 carbon atoms; R is selected ...	05/04/1976
3953431	Derivatives of digoxigenin Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali meta...	04/27/1976
3952030	Selenium-75 steroids Novel dimeric and monomeric selenium-75 derivatives of steroids are made by reacting a keto steroid with selenium-75 dioxide or selenious acid-Se75. The resulting diselenide dimers can be converted into monomeric compounds by the use of a cleaving reagent...	04/20/1976
3939187	15଱,-Sulfonyloxy-12ଲ-hydroxypregnanes and process for the preparation thereof 15଱-Sulfonyl-12ଲ-hydroxypregnanes of the formula ##SPC1## Wherein Ac is lower-acyl and R is alkyl, cycloalkyl, aralkyl or aryl, which are useful as intermediates for the production of digoxigenin, are produced by the selective sulfonic acid es...	02/17/1976
3939156	Cardenolides Novel cardenolides having desirable cardiac activity and which are readily reabsorbed internally, a process for their preparation and therapeutic compositions containing said cardenolides are disclosed....	02/17/1976

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Class 540/105 - Chalcogen bonded directly at the 14-position of the cyclopentanohydrophenanthrene ring system or double bond in the D ring (e.g., cardenolides, etc.)