Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 8183351 | Avermectin derivatives Novel avermectin derivatives of the formula (I) in which —C22R1-A-C23R2, R3, R4 and R5 have the meanings given in the description, processes for... | 05/22/2012 |
| 7560536 | Morning glory-derived anticancer agents, and novel ipomoeassin compounds Ipomoeassin compounds derived from morning glory plant material (especially Ipomoea sp. from Suriname) are useful as anti-cancer agents. The novel compounds also are useful for treating neurodegenerative disorders (such as Alzheimer's disease) in human patien... | 07/14/2009 |
| 7326691 | Compositions comprising amphotericin B, methods, and systems A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 μm to about 1.9 μm. Another composition also includes particles including at least about 95 wt % of amphot... | 02/05/2008 |
| 7285653 | Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis The present invention relates to nucleic acid coding for enzyme activities of spinosyn biosynthesis and to the relevant enzymes per se. Furthermore, the invention relates to methods for preparing spinsoyn derivatives and spinosyn precursors. ... | 10/23/2007 |
| 7265245 | Compounds useful for the treatment of diseases associated with the formation of amyloid fibrils The present invention provides new amyloidogenesis inhibiting compounds of formula (I): in which R1 is a —NRaRb group, where Ra and... | 09/04/2007 |
| 7259170 | Macrolides containing pharmaceutical compositions A pharmaceutical compound comprising a compound of formula I and a pharmaceutically acceptable 2-amino-1,3-propanediol beside one or more pharmaceutically acceptable excipient(s). ... | 08/21/2007 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7160867 | Rapamycin carbohydrate derivatives This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic ... | 01/09/2007 |
| 7115576 | Water-soluble antibiotic comprising an amino sugar, in the form of a polysaccharide conjugate The invention relates to novel pharmaceutical forms for antibiotics containing amino sugar, amphotericin B, daunorubicin and doxorubicin, in which the known side effects are reduced and which can be used in a simple manner. The antimycotic agent B is nephrotoxic. Th... | 10/03/2006 |
| 7084121 | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. M... | 08/01/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7034130 | Method for producing novel spinosyn derivatives The present invention relates to methods for producing novel spinosyn derivatives which are substituted with a 1-hydroxy-ethyl radical in the C-21 position and to novel spinosyn derivatives of this type per se and to their use for producing novel spinosyns. ... | 04/25/2006 |
| 7030084 | Drug-oligomer conjugates with polyethylene glycol components The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 04/18/2006 |
| 6927210 | Ectoparasiticidal aqueous suspension formulations of spinosyns The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an average particle size of 1 to 15 microns, a surfactant in an amount effe... | 08/09/2005 |
| 6864232 | Agent for treating visual cell function disorder The present invention provides an agent for treating retinopathy containing a tricyclo compound of formula (I) ... | 03/08/2005 |
| 6770290 | Amphotericin B liposome preparation A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small amount of organic solvent. The amphiphilic drug, such as Amphotericin B,... | 08/03/2004 |
| 6677309 | Anti-cancer drug aldehyde conjugate drugs with enhanced cytotoxicity compounds, compositions and methods Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2, dihetero-substituted anti-cancer drugs, including monomeric and dimeric alde... | 01/13/2004 |
| 6649595 | Regulation of biological events using novel compounds Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.... | 11/18/2003 |
| 6632443 | Water-soluble compositions of bioactive lipophilic compounds Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer g... | 10/14/2003 |
| 6613889 | Method for preparing salts of polyene macrolide esters This method is for preparing salts of amphotericin B methyl ester and other polyene macrolide esters. The steps of the process involve methylation by use of cesium carbonate for converting to methyl ester and significantly reducing side products, which ar... | 09/02/2003 |
| 6566509 | Multivalent macrolide antibiotics Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds at which bind to bacterial ribosomal RNA and/or to one or more proteins involved i... | 05/20/2003 |
| 6562796 | Derivatives of polyene macrolides and preparation and use thereof The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to ampho... | 05/13/2003 |
| 6515115 | Membrane filtration The invention relates to a process for isolating a desired water-soluble product from a fermentation broth wherein the broth is circulated along a ceramic membrane, and wherein a trans-membrane pressure of at least 1.5 bar is applied, whereupon an aqueous... | 02/04/2003 |
| 6369036 | Antifungal composition The present invention provides a method of preparing an improved antifungal composition containing an antifungal compound of the polyene type such as natamycin wherein the antifungal compound is incorporated into the composition in a form which shows an e... | 04/09/2002 |
| 6346610 | Process for preparing antifungal V-28-3M An industrially suitable process for preparing V-28-3M useful as an antimycotic agent by conducting methyl esterification of V-28-3 efficiently. V-28-2 is efficiently converted into V-28-3M by protecting the amino group of the amino sugar of V-28-3 with a... | 02/12/2002 |
| 6291436 | Direct action anti-mycotic A direct action anti-mycotic composition is provided which is a natamycin material having an average particle diameter of 10 microns or less and/or an average surface area to weight ratio of at least 2 m2 /g. The natamycin material may be utili... | 09/18/2001 |
| 6284736 | Amphotericin derivatives A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein R1 is a carboxylic acid group, a derivative thereof, a ketone residue, an aldehyde function or optionally substituted methyl; R2 is hydroxy, C... | 09/04/2001 |
| 6150143 | Natamycin recovery A process for the recovery of natamycin from a fermentation broth containing biomass and natamycin, which comprises: (a) disintegrating the biomass; and (b) separating the natamycin from the thus treated fermentation broth.... | 11/21/2000 |
| 6143726 | Complexes of N'-dimethylaminoacetylpartricin A dimethylaminoethylamide, or the salts thereof, and cholesterol 3-sulphate A complex containing N'-dimethylaminoacetylpartricin A dimethylaminoethylamide, as a salt or as the free base, and cholesterol 3-sulphate, in a molar ratio between 1:0.5 and 1:10, respectively.... | 11/07/2000 |
| 6090610 | Macrolide compound 0406 Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R1 is --COCH2... | 07/18/2000 |
| 6004995 | Macrolide compound 0406 Compound 0406 having a chemical structural formula represented by the chemical formula (1) below and having an excellent immuno suppressive activity, and pharmaceutically acceptable salts thereof. ##STR1## (wherein R1 is --COCH2... | 12/21/1999 |
| 5985845 | Methods for reducing mortality rates in poultry Poultry such as chickens and turkeys are treated with natamycin to reduce overall mortality and to reduce mortality rates due to the disease ascites.... | 11/16/1999 |
| 5981721 | Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof Processes for the preparation of high purity alkyl esters of polyene macrolide antibiotics are disclosed. The processes involve treating an amphoteric polyene macrolide antibiotic with an aldehyde to yield the corresponding Schiff base which is soluble in... | 11/09/1999 |
| 5965156 | Amphotericin B liposome preparation A novel composition and method for solubilizing amphiphilic drugs in a small amount of organic solvent for use in improved liposomes is disclosed. A phosphatidylglycerol is acidified in a small amount of organic solvent. The amphiphilic drug, such as Amph... | 10/12/1999 |
| 5945518 | Process for the preparation of anthracycline antibiotics A process for the preparation of antibiotics of the anthracycline class of formula (A), wherein R1 is hydrogen, OH, or OCOR2, wherein R2 is a C1 -C4 -alkyl group; which comprises the epimerization of ... | 08/31/1999 |
| 5942495 | Antibiotics The invention relates to an N-alkyl-N-glycosyl derivative of antifungal antibiotics of the polyene macrolide group of general formula 1(a), wherein M represents polyene macrolide antibiotics residues, R represents a variable part of sugar residue, R1... | 08/24/1999 |
| 5942611 | Process for natamycin recovery A new process for recovering high purity natamycin from fermentation broth containing natamycin comprises the steps of adjusting the pH of the broth to above about 10 and adding an amount of a water-miscible solvent, such as isopropanol, sufficient to dis... | 08/24/1999 |
| 5939399 | Polyene antibiotics, 3874 H1 to H6, processes for their preparation and use Novel polyene antibiotics, 3874 H1 to H6, processes for their preparation and use which are suitable for treating fungal diseases, trichomonad diseases, and for treating diseases associated with an increased steroid concentration.... | 08/17/1999 |
| 5902579 | Natamycin-containing streptomyces biomass and its use in animal feed Natamycin biomass comprising 5-60% natamycin, most preferably 25-60% natamycin, and methods for forming the biomass, are disclosed. The natamycin biomass can be mixed with compatible carrier to form a premix comprising 0.2-5% natamycin. The premlix may be... | 05/11/1999 |
