Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 7435816 | Synthesis of solanum glycosides The present invention relates to the chemical synthesis of solanum glycosides, in particular to the synthesis of solasonine as well as to novel β-monosaccharide intermediate compounds, of Formula (2), where R1 is a benzylidene, 4-nitrobenzylidene or 4-me... | 10/14/2008 |
| 7138427 | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed ... | 11/21/2006 |
| 6911325 | Process for the preparation of derivatives of Ruscus aculeatus steroid glycosides by enzymatic hydrolysis A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus Aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from aspergillus niger. ... | 06/28/2005 |
| 6861410 | Immunological adjuvant compositions The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable ... | 03/01/2005 |
| 6521600 | Compound, WF002, production thereof and use thereof The present invention provides a new bioactive compound of formula (I), which has an antimicrobial activity against pathogenic microorganisms, and a process for production thereof. Also provided are a pharmaceutical composition comprising the compound and... | 02/18/2003 |
| 6124442 | Process for extracting triterpene glycosides from botanical sources The process includes obtaining a liquid extract from a fresh plant source material and mixing the extract with a solution saturated with at least one element having an oxidation number of one or two or combinations thereof. The resulting mixture provides ... | 09/26/2000 |
| 6017906 | Polyamine conjugates for treatment of infection The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of ... | 01/25/2000 |
| 5908833 | Colon or ileum-specific steroid derivatives Novel compounds which are a glucocorticosteroid (GCS) chemically bound to a sugar, having the general formula GCS1 --O--Sugar1 for colon- or ileum-specific delivery of the GCS to inflamed bowel mucosa, as well as processes for their prepa... | 06/01/1999 |
| 5760009 | Spirostanyl glycosidal crystalline monohydrate A crystalline monohydrate of (3ଲ,5,25R)-3-(ଲ-D-cellobiosyl)oxy!spirostan-11-one that is useful as a hypocholesterolemic or antiatherosclerosis agent.... | 06/02/1998 |
| 5744453 | Polyamine conjugates for treatment of infection The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of ... | 04/28/1998 |
| 5695738 | Steroidal C-glycosides Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/o... | 12/09/1997 |
| 5606041 | Process for steroidal peracyl glycosides Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting -cellobiosyl bromide heptaalkanoate and ³... | 02/25/1997 |
| 5591836 | Cholesterol lowering compounds Disclosed are novel saponins containing 5-C-hydroxymethylhexose and a sterol or triterpene. These materials, when consumed by humans and animals, lower the cholesterol level in the blood. These compounds can be administered as pharmaceutical preparation t... | 01/07/1997 |
| 5583112 | Saponin-antigen conjugates and the use thereof Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.... | 12/10/1996 |
| 5563250 | Cleavable conjugates for the delivery and release of agents in native form The present invention provides cleavable conjugates whose linkers contain a labile bond that is cleavable under a variety of mild conditions, including weakly acidic. Since the agent may be bonded directly to the linker, cleavage can result in release of ... | 10/08/1996 |
| 5530107 | Method for making steroidal peracyl glycosides Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting -cellobiosyl bromide heptaalkanoate and ଲ... | 06/25/1996 |
| 5525480 | N- and O-substituted aminophenols, method and use for diagnosis The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R1, R2, R3, G and L are as hereinbefore defined. The present invention also provides intermediates fo... | 06/11/1996 |
| 5438125 | Sialic acid derivatives Sialic acid compounds of formula ##STR1## wherein X is hydrogen, a lower alkyl group or benzyl, Y is hydrogen or acetyl, Ac is acetyl, and the wavy line represents that the compound of the formula (I) includes both a -anomer and ଲ-anomer... | 08/01/1995 |
| 5426179 | Steroid compounds active on the cardiovascular system Steroid compounds active on the cardiovascular system of formula ##STR1## wherein X, n, R, R1 and R2 have the meanings mentioned in the description are described.... | 06/20/1995 |
| 5294703 | Process for preparing -D-cellobiose octaacetate Provided is a novel improved process for the preparation of -D-cellobiose octaacetate via the acetylative degradation of cellulose or cellulose acetate. The title compound is provided in high yield and quality in a facile one-pot process, amenable ... | 03/15/1994 |
| 5198537 | Digoxigenin derivatives and use thereof The present invention provides digoxigenin derivatives of the formula: ##STR1## wherein n is a whole number of from 1 to 4 and Z is a carboxyl group or a functional derivative derived therefrom. The present invention also provides digoxigenin conjuga... | 03/30/1993 |
| 5124441 | Therapeutically active compound and its use Therapeutically active organic compound exhibiting at least one group comprising a structure --S'--S"--R, wherein the group --S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitt... | 06/23/1992 |
| 5106963 | Phospholipid conjugates and their preparation Phospholipid conjugate compounds derived from cardiac glycosides and sters useful in liposome immunoassays are disclosed as well as their method of preparation.... | 04/21/1992 |
| 5053497 | Phospholipid conjugates and their preparation Phospholipid conjugate compounds derived from cardiac glycosides and steroids useful in liposome immunoassays are disclosed as well as their method of preparation.... | 10/01/1991 |
| 5010185 | Processes for tigogenin beta-cellobioside Improved processes for the synthesis of tigogenin beta-cellobioside, a known hypocholesterolemic agent, using cellobiose heptaacetate and tigogenin as starting materials.... | 04/23/1991 |
| 5003054 | Ouabain triacetate derivative compounds A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase mater... | 03/26/1991 |
| 4895836 | Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them | 01/23/1990 |
| 4780314 | Isolation and purification of a digitalis-like factor This invention relates to a novel recovery process for obtaining the small molecular weight, digitalis-like factor, and further relates to purification of the digitalis-like factor. This invention also relates to the identification and characterization of... | 10/25/1988 |
| 4603196 | Process for the preparation of ଲ-methyldigoxin The invention relates to a process for the preparation of ଲ-methyldigoxin by the selective methylation of digoxin with dimethyl sulfate in the presence of a basic strontium compound and, if appropriate, of an inert inorganic adsorbent. Strontium hyd... | 07/29/1986 |
| 4562250 | Steroidal glycosides produced by Yucca tissue culture Methods for the production of steroids (sapogenins) and steroidal glycosides (saponins) from cell, root-cell and shoot tissue cultures of the Yucca plant. The cultures were established and maintained in a suitable nutrient plant cell medium supplemented w... | 12/31/1985 |
| 4546097 | Saponin-based polyether polyols, pharmaceutical compositions and a method of using same Digitonin and digitonin-related saponins are derivatized by alkoxylation. The adducts have lower toxicity, higher solubility, and reduced ability to form insoluble complexes with cholesterol, as compared to the starting material. The adducts are particula... | 10/08/1985 |
| 4482706 | Steroid saponins Novel steroid saponin compounds (XR-1) and (XR-2) are extracted from Solanam aculeatissimum, a plant belonging to the Solanum genus, and 16-dehydropregnenolone is obtained by hydrolyzing the said compounds, subjecting the hydrolyzed product to Marker's de... | 11/13/1984 |
| 4461763 | Oximes of 3'"-dehydrocardenolide tridigitoxosides The present invention provides 3'"-dehydrocardenolide tridigitoxoside oximes of the general formula: ##STR1## in which R1 is a hydrogen atom or an alkyl radical containing up to 3 carbon atoms, R2 is a hydrogen atom or a lower a... | 07/24/1984 |
| 4436735 | Ketals of 3'"-dehydrocardenolide tridigitoxosides The present invention provides ketals of 3'"-dehydrocardenolide tridigitoxosides of the general formula: ##STR1## in which R1 and R2 are identical alkyl radicals containing up to 3 carbon atoms or together represent a cyclic ket... | 03/13/1984 |
| 4436828 | Reactive asymmetrical dicarboxylic acid esters and reagents for the investigation of cardiac glycosides New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R2 and R3, which may be the same ... | 03/13/1984 |
| 4423208 | Affinity gel-adsorbent An improved affinity gel-adsorbent for use in an improved method of purifying glucocorticoid receptor by affinity chromatography and having the formula: ##STR1## R1 : H or OH or .dbd.O R2 : H or F R3 : H or F R4 | 12/27/1983 |
| 4230702 | Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents A readily enterally absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly enterally absorbable, is disclosed which comprises a pharmacologically, effective amount of at least one such pharmacologically active ag... | 10/28/1980 |
| 4202888 | Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof A readily enterally absorbable pharmaceutical composition of cardiac glycosides is disclosed which comprises a therapeutically-effective amount of at least one cardiac glycoside distributed in a vehicle comprising an absorption-enhancing amount of at leas... | 05/13/1980 |
| 4184037 | Digoxin oxidized product Reagent of value in the radioimmunoassay of digoxin. Also provided by the invention are a radioimmunoassay method utilizing such reagent and a test kit suitable for use in performing the assay.... | 01/15/1980 |
| 4145528 | Process for preparing ଲ-methyldigoxin Preparation of ଲ-methyldigoxin in the presence of dimethyl formamide, an inert solvent, methyl ester of a sulphuric acid, and strontium hydroxide.... | 03/20/1979 |
