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| Number | Title | Issue Date |
| 7812152 | Amphiphilic cyclodextrin derivatives, method for preparation thereof and uses thereof The invention relates to cyclodextrin derivatives of formula (I): in which: R1=—NH-E-AA-(L1)p(L2)q where E=a linear or b... | 10/12/2010 |
| 7700763 | 3-triazolyl-galactoside inhibitors of galectins The present invention relates to novel compounds, the use of said compounds as a medicament as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal. Said galectin is preferably a galectin... | 04/20/2010 |
| 7385052 | Process for the production of multiple cross-linked hyaluronic acid derivatives The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products cont... | 06/10/2008 |
| 7304148 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 12/04/2007 |
| 7259152 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral formulations containing doses adapted for administration to obtain a re... | 08/21/2007 |
| 7148200 | Method for treating cancer A method for treating a cancer. The cancer excluding an adenocarcinoma and being epithelioma, glioma, sarcoma, melanoma, lymphoma or leukemia; or the cancer is an adenocarcinoma cancer excluding colon cancer, lung cancer and gastric cancer. The method comprises admi... | 12/12/2006 |
| 7101873 | Pyrimidinedione derivatives Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them are useful for the tre... | 09/05/2006 |
| 7101995 | Compositions and processes using siRNA, amphipathic compounds and polycations Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell. ... | 09/05/2006 |
| 7094763 | Substituted fused heterocyclic C-glycosides This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. ... | 08/22/2006 |
| 6992203 | Metal complexes produced by Maillard Reaction products A method is disclosed for the formation of metal chelates which are able to remain stable in high alkaline environments when compared to metal chelates produced from a reaction with amino acids. The method involves the reaction of sugars, amino groups, and metal com... | 01/31/2006 |
| 6906042 | Micelles The invention provides micelles, pharmaceutical formulations comprising micells, solutions comprising micells, methods for preparing micells, methods for delivering micells to patients, and methods for treating sepsis, endotoxemia, septic shock and systemic inflamat... | 06/14/2005 |
| 6884788 | Thiol-modified hyaluronan The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated hyaluronan... | 04/26/2005 |
| 6872819 | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials are comprised of threads embedded in a matrix, wherein both t... | 03/29/2005 |
| 6861512 | Separation of olefinic isomers The geometric isomers of olefins and olefinic compounds are separated by means of liquid chromatography using a stationary phase comprising an organosilane with a pendant aliphatic functional group such as C18 and a mobile phase which includes an additive... | 03/01/2005 |
| 6770629 | Administration of a sulfopyranosylacylglycerol to treat certain cancers A medicament containing at least one compound selected from the group consisting of compounds represented by General formula (1): wherein R101 represents an acyl residue of an unsaturated higher fatty acid, an... | 08/03/2004 |
| 6723709 | Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion. ... | 04/20/2004 |
| 6699846 | Mono- and disaccharides for the treatment of nitric oxide related disorders Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to monophosphoryl lipid A but with notable reduction in proinflammator... | 03/02/2004 |
| 6693180 | Composite sponge wound dressing made of ଲ-Chitin and Chitosan and method for producing the same The present invention relates to a composite sponge wound dressing and method for producing the same. Chitosan and ଲ-Chitin is mixed in a specific ratio for forming the sponge for wound repairing. Particularly, when said ratio is between 0.1~1, the ... | 02/17/2004 |
| 6653456 | Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino... | 11/25/2003 |
| 6620927 | Thiol-modified hyaluronan The present invention relates to biscarbodiimides, thiourea derivatives, urea derivatives, and cross-linked hyaluronan derivatives having at least one intramolecular disulfide bond, and methods of preparation thereof. The invention also includes thiolated... | 09/16/2003 |
| 6608042 | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof The present invention relates to pharmaceutical compositions containing as an active ingredient at least one oligosaccharide of formula: ##STR1## to novel oligosaccharides of formula (I), to mixtures thereof and to methods for their preparation.... | 08/19/2003 |
| 6596707 | Monovalent saccharides and uses thereof The subject invention relates to monovalent oligosaccharides and their use, for example, in the treatment and prevention of mammalian disease caused by infection with Shiga toxin (ST) or Shiga-like toxin (SHL). In particular, the trisaccharide globotriose... | 07/22/2003 |
| 6555645 | Degradable polyurethane resin The invention is a degradable polyurethane resin obtained by reacting 2,5-/2,6-diisocyanatomethylbicyclo[2.2.1]heptane and/or a modified compound thereof with polyol comprising a single compound, mixture or copolycondensate selected from the group consist... | 04/29/2003 |
| 6528629 | Malto-oligosaccharide derived glycosides Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an alcohol or a thiol under conditions suitable to form a ... | 03/04/2003 |
| 6511965 | Ether type lipid A 1-carboxylic acid analogs A compound of formula (I) below, which exhibits excellent macrophage activity inhibitory action, is useful for the treatment or prophylaxis of inflammatory disorders, autoimmune diseases or septicemia. In a preferred embodiment, R1 and R3 | 01/28/2003 |
| 6498246 | Glycosaminoglycan derivatives and processes for preparing same The invention provides novel glycosaminoglycan derivatives having a repeating unit structure of two saccharides of hexosamine and hexuronic acid as a backbone structure, in which the bonds between 2- and 3-positions carbon atoms of hexuronic acid as its c... | 12/24/2002 |
| 6444797 | Chitosan microflake and method of manufacturing the same Disclosed is a chitosan microflake which is exceptionally improved in coatability to the skin. The chitosan microflake is manufactured by dissolving chitosan in a weak acidic, aqueous organic acid solution to give a chitosan solution, extracting chitosan ... | 09/03/2002 |
| 6417171 | Preparation of polymers by interfacial derivatization This invention utilizes methods of emulsion chemistry to derivative polymers, as distinguished from the synthetic methods of the prior art, whereby such polymers are derivative in a true solution. The derivative polymers are useful in that they may be rea... | 07/09/2002 |
| 6406894 | Process for preparing polyvalent and physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions and the use thereof for preparing carbohydrate building blocks A process for preparing polyvalent, physiologically degradable carbohydrate-containing polymers by enzymatic glycosylation reactions is described. The carbohydrate-containing polymers thus prepared may be used for preparing carbohydrate building blocks. T... | 06/18/2002 |
| 6399590 | Phosphoglycolipid and methods for its use The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2-Deoxy-6-O-[2-deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoy l]-2-[(R)-3-octadecanoyloxytetradecanoylamino]-ଲ-D-glucopyranosyl]-2-[ ... | 06/04/2002 |
| 6391857 | Methods and compositions for endothelial binding Novel methods and compositions are provided for modulating homing of leukocytes, particularly lympho-cytes, where the compounds are cross-reactive with Neu5Ac2-3Gal댡-X[Fuc댑-y]GlcNAc, where one of x and y is three and the other is four. These... | 05/21/2002 |
| 6353095 | Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having a formed stereogenic center of R configuration, as well as methods of synthesizing the same.... | 03/05/2002 |
| 6299897 | Inhibition of selectin binding This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides ... | 10/09/2001 |
| 6261788 | Diagnostic assays for infectious parasitic helminths Species of schistosoma , such as schistosoma mansoni, S. japonicum and S. haematobium, which infect humans and animals, synthesize the Lewisx (Lex), lacdiNAc (LDN) and fucosylated LDN (LDNF) carbohydrate antigens. Parasitic helminths... | 07/17/2001 |
| 6191271 | Synthetic divalent sLex containing polylactosamines and methods for use The present invention is directed to novel compositions and their use in the treatment of inflammatory responses. Specifically, the invention is directed to novel synthetic oligosaccharide constructs and their use to block lymphocyte binding to correspond... | 02/20/2001 |
| 6184366 | Substituted liposaccharides useful in the treatment and prevention of endotoxemia Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing ... | 02/06/2001 |
| 6162797 | Derivatives of K5 polysaccharide having high anticoagulant activity Derivatives of the K5 polysaccharide having anticoagulant activity higher than heparin, obtained by a process including the steps of reacting: with an organic base a solution of K5 polysaccharide N-deacetylated, N-sulfated and epimerized at least to an id... | 12/19/2000 |
| 6156544 | Process for the preparation of N-acetylneuraminic acid A method for the preparation of N-acetyl-D-neuraminic acid (NANA) N-acetyl-D-glucosamine (NAG) is described.... | 12/05/2000 |
| 6136790 | Carbohydrate mimetics having antiadhesive properties The invention relates to carbohydrate mimetics, which inhibit the binding of selectin to carbohydrate ligands, of the formula I ##STR1## excluding the compounds sialyl-Lewis-X and -A and their derivatives which, instead of an N-acetyl group, carry th... | 10/24/2000 |
| 6133239 | Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell rolling and adhesion under dynamic flow system An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal 댒.fwdarw.3 sialylation and internal 댑.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosam... | 10/17/2000 |
