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| Number | Title | Issue Date |
| 8003782 | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates with or without natural or synthetic essential oils can work effectively as a topical, oral or mucosal pharmaceutical composition. Such pharmaceutical compositio... | 08/23/2011 |
| 7754875 | Halide-free glucosamine base-organic acid salt compositions A salt of a glucosamine base having a purity of at least about 99 wt. % and a maximum halide content of about 0.01 wt. %, and an organic acid. The organic acid that is saltified with the glucosamine base is preferably a hydroxyacid or a ketoacid. Preferably, the sal... | 07/13/2010 |
| 7741474 | Solubilising polysaccharides substituted with dydrophilic and hydrophobic groups This invention relates to novel carbohydrate polymers with hydrophobic and hydrophilic side-groups suitable for solubilising, for example, hydrophobic drugs. The chain length of the carbohydrate polymeric backbone, and the type and number of the hydrophobic and hydr... | 06/22/2010 |
| 7622576 | Halide-free glucosamine base and method of preparation A glucosamine base having a pure level of at least about 99.0 wt. % and a maximum halide content of 0.01 wt. %. The pure glucosamine base is prepared by reacting a glucosamine halide, e.g., glucosamine hydrochloride, with a lithium base in the presence of a C1 | 11/24/2009 |
| 7511134 | Method for preparing N-acetylglucosamine A method for preparing n-acetylglucosamine starting from glucosamine base having a purity level of at least about 99 wt. % and a maximum halide content of about 0.01 wt %. The glucosamine base is slurried in a diluent comprising a C1-C4 straigh... | 03/31/2009 |
| 7435812 | Method for preparing a glucosamine compound and compound thus obtained Method for preparing a compound comprising protonated glucosamine and Cl−, Na+ and SO42− ions, in which (a) glucosamine hydrochloride and a stoichiometric excess of sodium sulphate are placed in water, (b) the mixture ... | 10/14/2008 |
| 7429573 | Method for increasing the bone mineral density and bone micro-architecture or connectivity of a mammal using N-acylated glucosamines A method of treating a mammal for a purpose selected from the group consisting of (a) increasing bone mineral density (BMD), (b) treating low BMD, (c) preventing and treatment of low impact fractures, (d) treatment of high impact fractures; (e) treating osteoporosis... | 09/30/2008 |
| 7393937 | N-acetylglucosamine derivatives and use thereof The present invention relates to An N-acetylglucosamine derivative represented by the following formula (1), and a hyaluronic acid production promoting agent containing the same and a skin external preparation containing the same: | 07/01/2008 |
| 7388001 | Halide-free glucosamine sulfate compositions and methods of preparation Glucosamine sulfate having a purity of at least about 99 wt. %, and a maximum halide content of about 0.01 wt. %. Preferably, the glucosamine sulfate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-... | 06/17/2008 |
| 7388000 | Halide-free glucosamine phosphate compositions and methods of preparation Glucosamine phosphate having a purity of at least about 99 wt. %, and a maximum halide content of about 0.01 wt. %. Preferably, the glucosamine phosphate is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, wa... | 06/17/2008 |
| H2218 | Glucosamine and method of making glucosamine from microbial biomass Glucosamine suitable for human or animal consumption is disclosed. The glucosamine is derived from microbial biomass containing chitin. Suitable starting materials include substantially uniform microbial fungal sources, such as fungal sources derived from Aspergi... | 06/03/2008 |
| 7345030 | Use of n-acetyl-d-aminoglycosamine in treatment of organ lesions related to toxicosis of drugs or chemicals The present invention is directed to the use of N-acetyl-D-glucosamine to treat organ lesions caused by toxicants and drugs. The present invention is also directed to a method for treating organ lesions caused by toxicant comprising administering to a patient suffer... | 03/18/2008 |
| 7345165 | Method for preparing water-soluble free amine chitosan A method for the preparation of water-soluble chitosan with high purity and biological activity includes steps of: reacting chitosan oligo sugar acid salt, covalently bonded to an organic or inorganic acid, with trialkylamine in phosphate buffered saline followed by... | 03/18/2008 |
| 7332304 | Process and materials for production of glucosamine and N-acetylglucosamine A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorga... | 02/19/2008 |
| 7323425 | Crosslinking of hyaluronan solutions and nanofiberous membranes made therefrom A method for producing a non-chemically crosslinked hyaluronan is provided which involves contacting a sample of hyaluronan with an acidic solvent/water mixture for a period of time and at a temperature sufficient to effect crosslinking, wherein the acidic solvent/w... | 01/29/2008 |
| 7265098 | Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen... | 09/04/2007 |
| 7259152 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral formulations containing doses adapted for administration to obtain a re... | 08/21/2007 |
| 7244830 | Glycopolymers and free radical polymerization methods A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a saccharide moiety connected to said linking group, optionally a second penden... | 07/17/2007 |
| 7214667 | Drugs against articular failure The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for tr... | 05/08/2007 |
| 7202230 | Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anas... | 04/10/2007 |
| 7196073 | Imine-forming polysaccharide adjuvants and immunostimulants The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or ... | 03/27/2007 |
| 7195675 | Chitosan-containing polysaccharide, method for preparing the same and use thereof The present invention herein provides a chitosan-containing polysaccharide and a method for the preparation thereof as well as a medicine and a food containing the polysaccharide. The chitosan-containing polysaccharide is prepared by a method comprising the s... | 03/27/2007 |
| 7192984 | Compositions of polyacids and polyethers and methods for their use as dermal fillers The present invention relates to improved methods for filling the skin for cosmetic or medical purposes. Compositions comprising carboxymethyl cellulose (CMC), polyethylene oxide (PEO) and calcium ions can be made and have physical properties that depend on the amou... | 03/20/2007 |
| 7160856 | α-O-linked glycoconjugates, methods of preparation and uses thereof The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tum... | 01/09/2007 |
| 7157444 | Aminosalicylate derivatives for treatment of inflammatory bowel disease Therapeutic 5-aminosalicylic acid derivative compositions having general formula (I), wherein R is a 1-deoxy sugar residue or a poly(ethylene glycol) chain-containing residue, are provided. The compositions enable topical delivery of 5-aminosalicylic acid to the gas... | 01/02/2007 |
| 7140433 | Diamine terminated primary amine-aldehyde sulfur converting compositions and methods for making and using same A new class of sulfur scavenging or converting compositions is disclosed comprising diamine terminated, amine-aldehyde adducts, where the adducts are substantially bimolecular amine-aldehyde adducts and the composition is substantially free of trimer and/or triazine... | 11/28/2006 |
| 7141556 | Process for the preparation of glucosamine salts This invention relates to a process for the preparation of glucosamine sulfate, glucosamine hydroiodide, glucosamine pyruvate, glucosamine phosphate or their mixtures with glucosamine hydrochloride, by electrodialysis. Starting from glucosamine hydrochloride, the ex... | 11/28/2006 |
| 7138386 | Preventives or remedies for arthritis The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereo... | 11/21/2006 |
| 7132412 | Treatment of skin diseases using a pharmaceutical preparation in colloidal form A new use of a suitable colloidal mixture of hyaluronic acids, of different molecular weights mixed together in a proper ratio in the treatment of the cutaneous diseases is described. ... | 11/07/2006 |
| 7125860 | Cross-linked derivatives of hyaluronic acid The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I) hereinafter depicted and a process for the preparation of said cross-lin... | 10/24/2006 |
| 7125968 | Functional chitosan derivative A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosa... | 10/24/2006 |
| 7115588 | Methods for treating a breach or puncture in a blood vessel The present invention relates to compositions comprising semi-crystalline β-1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimu... | 10/03/2006 |
| 7115215 | Method and composition for removing sulfides from hydrocarbon streams A method and composition for reducing the levels of hydrogen sulphide and mercaptans in hydrocarbon streams. The method comprises contacting the gas stream with a composition comprising the reaction product of mixing monoethanolamine, diglycolamine and formaldehyde.... | 10/03/2006 |
| 7109280 | Block copolymers and preparation thereof The present invention relates to block copolymers for applications in medicine and biotechnology and synthesis thereof. Block copolymers comprise polyvalent N-Acetyl Glucosamine (NAG) which bind more efficiently to lysozyme than NAG itself. The effective inhibition ... | 09/19/2006 |
| 7102023 | Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention ... | 09/05/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7094582 | Cell-free production of glucosamine Methods for cell-free production of glucosamine from starch, maltodextrin or glycogen or from fructose and a source of amino groups are disclosed. Also disclosed are cellular extracts comprising glucosamine-6-phosphate synthase activity, as well as a cellular extrac... | 08/22/2006 |
| 7087745 | Three-dimensional structures containing hyaluronic acid derivatives obtained by the supercritical antisolvent technique Biocompatible and biodegradable, three-dimensional structures containing hyaluronic acid derivatives, obtained by the technique of precipitation induced by supercritical antisolvent (SAS), can be used in the field of medicine and surgery. ... | 08/08/2006 |
| 7077884 | Hydrogen sulfide scrubber using polymeric amine and associated methods A hydrogen sulfide scrubber includes first and second scrubber tanks with scrubber media contained therein. Scrubbing solution circulators each include a dispenser for dispensing scrubbing solution into contact with the scrubber media, a sump for collecting the scru... | 07/18/2006 |
| 7049434 | Derivatives of hyaluronan The invention describes new hyaluronan derivatives where the hydroxyl groups are esterified or carbamoylated in amounts ranging from 0.01% to 100% and the carboxyl groups are either totally or partially esterified with alcohols or are in the form of salt. ... | 05/23/2006 |