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| Number | Title | Issue Date |
| 8071757 | Aryl/alkyl vinyl sulfone hyaluronic acid derivatives A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherboun... | 12/06/2011 |
| 8049002 | Processes for chemical synthesis of lipochitooligosaccharides Processes for the synthesis of lipochitooligosaccharides were developed. A fully acylated oligoglucosamine precursor is prepared and reacted with a glucosamine monomer that has an amine protecting phthaloyl group. With removal of the phthaloyl group, a fatty acid ma... | 11/01/2011 |
| 7956180 | Dried and agglomerated hyaluronic acid product The present invention relates to products comprising hyaluronic acid or a salt thereof, which product is dried and agglomerated as defined herein, various compositions and articles comprising the product or compositions of the invention, methods of producing the pro... | 06/07/2011 |
| 7868165 | Process for the isolation and stabilization of low-molecular weight aminoglycans form waste egg shells A process for the isolation of low-molecular weight aminoglycan compound of formula I made up of alternating glucuronic acid and N-acetyl glucosamine units; from a hitherto unexploited natural source of waste egg shells; which process comprises the steps of: ... | 01/11/2011 |
| 7825240 | Cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, and their shaping as support materials There are described novel cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, their shaping as support materials useful for the separation or preparation of enan... | 11/02/2010 |
| 7662954 | Outer layer having entanglement of hydrophobic polymer host and hydrophilic polymer guest An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desi... | 02/16/2010 |
| 7579460 | Method for tagging of carbohydrates with active methylene compound The present invention relates to the method for tagging of carbohydrates with active methylene compound. Particularly, it relates to the method for tagging of carbohydrates with active methylene compound comprising the step of preparing carbohydrate conjugate in whi... | 08/25/2009 |
| 7456275 | Hyaluronic acid modification product The present invention provides a safe hyaluronic acid base material that is suitable for use in practical hyaluronic acid pharmaceutical preparations capable of distribution at room temperature and having such a low viscosity that injection is easy. The hyaluronic a... | 11/25/2008 |
| 7385052 | Process for the production of multiple cross-linked hyaluronic acid derivatives The present invention relates to a process for the production of cross-linked hyaluronic acid (HA) derivatives, in particular multiple, e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked HA derivatives, products cont... | 06/10/2008 |
| 7348424 | Polysaccharide containing phosphorylcholine group and process for producing the same The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide conta... | 03/25/2008 |
| 7335355 | Antimicrobial agent A method of identifying an agent that enhances the anti-microbial activity of cationic anti-microbial peptides by blocking the inhibitory effects of the proteinase/glycosaminoglycan pathway, which method comprises: (i) providing, as a first component, a cationic ant... | 02/26/2008 |
| 7288532 | Modified chitosan polymers and enzymatic methods for the production thereof The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the presence of a chitosan polymer or oligomer to produce a modified chitosan p... | 10/30/2007 |
| 7259152 | Methods and compositions using sulodexide for the treatment of diabetic nephropathy The present invention provides oral formulations of Sulodexide for the treatment of diabetic nephropathy in patients with both insulin dependent and non-insulin dependent diabetes mellitus. Oral formulations containing doses adapted for administration to obtain a re... | 08/21/2007 |
| 7238677 | Prevention of urogenital infections The invention provides hyaluronic acid compounds and derivatives thereof for preventing urogenital infections by a variety of pathogens, as well as compositions, articles and methods for treating and preventing urogenital infections. ... | 07/03/2007 |
| 7229977 | Composition for soluble films with a new hydrolyzed polysaccharide The invention is concerned with film-forming compositions containing hydrolysates of the exopolysaccharide YAS34 for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed form... | 06/12/2007 |
| 7226611 | Glycosaminoglycan/collagen complexes and use thereof The present invention is intended to offer a novel material which combines cell-adhesive proteins such as collagen with GAG polymers to construct an environment similar to an extracellular matrix, capable of controlling differentiation and proliferation of cells. Th... | 06/05/2007 |
| 7226972 | Process for cross-linking hyaluronic acid to polymers The present invention provides a process for the production of hyaluronic acid (HA) derivatives cross-linked with another polymer, in particular multiple e.g. double cross-linked hyaluronic acid derivatives. The invention also provides novel cross-linked derivatives... | 06/05/2007 |
| 7211662 | Soluble highly branched glucose polymers and their method of production The invention relates to soluble highly branched glucose polymers having a reducing sugar content of less than 1%, characterized in that they have a level of α-1,6 glucoside bonds greater than 10%, preferably of between 12 and 30%, a Mw value of between 0.35×10 | 05/01/2007 |
| 7208593 | Self-cross-linked alkyl cellulose A process for producing a self-cross-linking alkyl cellulose derivative, which includes irradiating, with radioactive rays, a mixture of a starting alkyl cellulose derivative (the number of carbon atoms of the alkyl group is 1 through 3, the alkyl group may be subst... | 04/24/2007 |
| 7205284 | Potent immunostimulants from microalgae Immunostimulatory polysaccharides can be preferentially extracted from food-grade microalgae using an aqueous ethanol extraction procedure. The resulting preparations exhibit extremely potent immunostimulatory activity. The preferential extraction of these immunosti... | 04/17/2007 |
| 7202230 | Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical hemostatic activity, to be used in both venous and arterial vascular anas... | 04/10/2007 |
| 7196180 | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same Methods for chemical modification of hyaluronic acid, formation of amine or aldehyde functionalized hyaluronic acid, and the cross-linking thereof to form hydrogels are provided. Functionalized hyaluronic acid hydrogels of this invention can be polymerized in situ, ... | 03/27/2007 |
| 7196073 | Imine-forming polysaccharide adjuvants and immunostimulants The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or ... | 03/27/2007 |
| 7196072 | High molecular weight polysaccharide fraction from with immunostimulatory activity A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mann... | 03/27/2007 |
| 7189392 | Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phospha... | 03/13/2007 |
| 7169309 | Polysaccharides with oxime or amine functions which are used for water treatment and sludge conditioning The invention relates to a particular polymer which is derived from a copolymer polysaccharide formed by a main chain comprising similar or different anhydrohexose units and branches including at least one neutral or anionic anhydropentose and/or anhydrohexose unit.... | 01/30/2007 |
| 7160517 | Apparatus and methods for the automated synthesis of oligosaccharides One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the p... | 01/09/2007 |
| 7138386 | Preventives or remedies for arthritis The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereo... | 11/21/2006 |
| 7138441 | Bioabsorbable blends and surgical articles therefrom Blends made of bioabsorbable materials including glycolide, lactide, caprolactone, dioxanone, trimethylene carbonate, alkylene glycols, esteramides, etc., and polymers and copolymers thereof with cyanoacrylates are described. Processes for making the polymers and su... | 11/21/2006 |
| 7132412 | Treatment of skin diseases using a pharmaceutical preparation in colloidal form A new use of a suitable colloidal mixture of hyaluronic acids, of different molecular weights mixed together in a proper ratio in the treatment of the cutaneous diseases is described. ... | 11/07/2006 |
| 7125860 | Cross-linked derivatives of hyaluronic acid The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I) hereinafter depicted and a process for the preparation of said cross-lin... | 10/24/2006 |
| 7115417 | Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of sof... | 10/03/2006 |
| 7091191 | Modified hyaluronic acid for use in musculoskeletal tissue repair The present invention includes hyaluronic acid complexes of a monovalent alkali metal salt of hyaluronic acid and a tetra alkyl ammonium halide that are suitable for incorporation with tissue scaffolds that are suitable for use in repair and/or regeneration of musco... | 08/15/2006 |
| 7074335 | Method of producing hierarchical porous beads The present invention is a method of producing porous beads, which comprises the steps of providing a first liquid phase comprising a bead matrix material and essentially edgy templating particle(s), said particle(s) being treated with a surface modifying agent; pro... | 07/11/2006 |
| 7056678 | Polysaccharide structure and sequence determination The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixtur... | 06/06/2006 |
| 7053068 | Chitosan-thio-amidine conjugates and their cosmetic as well as pharmaceutic use By the reaction of chitosan with iminothiolactones such as 2-iminothiolane, thiol groups can be covalently immobilized on the polymer. The resulting chitosan derivatives exhibit thiol groups which are capable of forming inter- and intramolecular disulfide bonds. Bec... | 05/30/2006 |
| 7030101 | Compositions of β-glucans and specific antibodies Compositions and kits comprising combinations of β-glucans and specific immunoglobulins are disclosed. The compositions and kits are useful in methods of preventing or treating infection by a pathogenic microorganism, in which β-glucan is administered to a subject... | 04/18/2006 |
| 7014860 | Hyaluronic acid gel, process for producing the same, and medical material containing the same Production of a hyaluronic acid gel, which comprises keeping hyaluronic acid in water at a hyaluronic acid concentration of at least 5 wt % in the presence of an acid component in an amount at least equimolar with the carboxyl groups in the hyaluronic acid. ... | 03/21/2006 |
| 7008932 | Hyaluronic acid in soft gel form An orally administered soft gelatin formulation preparation of low molecular weight Hyaluronic Acid (HA) for use as a nutritional supplement to provide the primary benefit of internally causing the softening of the human skin. ... | 03/07/2006 |
| 7005426 | Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and us... | 02/28/2006 |
