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| Number | Title | Issue Date |
| 8178663 | Ester derivatives of hyaluronic acid for the preparation of hydrogel materials by photocuring The present invention relates to hyaluronic acid ester derivatives, whose carboxylic groups are partially esterified with hydroxy groups of propiophenone derivatives, to the hydrogel materials consisting of the said hyaluronic acid ester derivatives, to their prepar... | 05/15/2012 |
| 8129518 | Synthetic polysaccharide antigens for immunological intervention in disease Provided are synthetic polysaccharide antigens (SPAs) with anti-inflammatory or inflammatory immunomodulatory properties, depending on their structure. Also provided are compositions comprising these SPAs, and methods of using these SPAs and compositions to either p... | 03/06/2012 |
| 8124757 | Thiol-modified macromolecule derivatives and cross-linked materials thereof The disclosed is thiol-modified macromolecule derivatives having the general formula of (I) or (II), as well as the disulfide bond cross-linked materials and the thiol-reactive crosslinker cross-linked materials, wherein R1 and R2 are alkylene ... | 02/28/2012 |
| 8093374 | Bismuth hyaluronate, the preparation method and the use thereof The present invention discloses a bismuth hyaluronate, characterized in that the bismuth content is from 0.5% to 40%, and the glucuronate content is from 20% to 45%, based on dry weight. Also provided is a method for the preparation of said bismuth hyaluronate compr... | 01/10/2012 |
| 8088916 | Hyaluronic acid-methotrexate conjugate An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein meth... | 01/03/2012 |
| 8071756 | Polysaccharide pseudo-sponge A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide o... | 12/06/2011 |
| 7692000 | Hyaluronan (HA) esterification via acylation technique for moldable devices A series of novel, melt- or mold-processable HA esters with varying aliphatic chain lengths are synthesized from silyl HA-quaternary (quat.) ammonium salt complex (preferably silyl HA-CTA, a silylated HA complex with cetyltrimethyl ammonium salt). Introduction of al... | 04/06/2010 |
| 7645873 | 6″-amino-6″-deoxygalactosylceramides This invention relates to galactosylceramide compounds. ... | 01/12/2010 |
| 7414126 | Process for the preparation of topiramate The present invention relates to a process for the preparation of topiramate, intermediates in this process and a process for the preparation of these intermediates. ... | 08/19/2008 |
| 7371738 | Method of transdermal drug delivery using hyaluronic acid nanoparticles The present invention relates to the development of a hyaluronic acid and hyaluronic acid hybrid nanoparticle systems for the administration of active molecules, peptides, DNA and/or other hydrophilic or hydrophobic molecules, the composition of hyaluronic acid and ... | 05/13/2008 |
| 7361644 | Specific antagonist for both E- and P-selectins Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 04/22/2008 |
| 7355037 | Thermolabile hydroxyl protecting groups and methods of use Provided is a hydroxyl-protected alcohol of the formula R—O—Pg, wherein Pg is a protecting group of the formula: wherein Y, Z, W, R1, R1a, R2, R2a, R | 04/08/2008 |
| 7348424 | Polysaccharide containing phosphorylcholine group and process for producing the same The present invention is a method for manufacturing a phosphorylcholine group-containing polysaccharide wherein the aldehyde derivative-containing compound obtained by the oxidative ring-opening reaction of glycerophosphorylcholine is added to a polysaccharide conta... | 03/25/2008 |
| 7335512 | Marker for measuring liver cirrhosis The invention provides methods and kits to detect liver cirrhosis in mammals. The diagnostic test is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum. ... | 02/26/2008 |
| 7335500 | Production of fucosylated carbohydrates by enzymatic fucosylation synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. The phosphorylated glycosides... | 02/26/2008 |
| 7331920 | Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, wherein the groups A1 | 02/19/2008 |
| 7321034 | Process for the physical depolymerization of glycosaminogylcanes and products obtained thereform The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and fo... | 01/22/2008 |
| 7304148 | Sugar chain asparagine derivatives, sugar chain asparagine, sugar chain, and processes for producing these An asparagine-linked α2,3-oligosaccharide having undeca- to hepta-saccharides, an asparagine-linked α2,6-oligosaccharide having undeca- to hepta-saccharides and containing fluorine and an asparagine-linked oligosaccharide derivative containing at least one fucose ... | 12/04/2007 |
| 7285661 | Starch derivatives, starch active substance conjugates, method for the production thereof and their use as medicaments The invention relates to starch derivatives of formula (I), in which: X represents a bromine or iodine atom; R″ represents a straight-chain or branched alkyl group, aryl group or aralkyl group, and; R—CO— represents an oxidized substituted or unsubstituted sta... | 10/23/2007 |
| 7273934 | Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC group; a 3-branched asparagine-linked oligosaccharide derivative which... | 09/25/2007 |
| 7273729 | Chondroitin synthase and DNA encoding the enzyme A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferase activity and N-acetylgalactosamine transferase activity. ... | 09/25/2007 |
| 7244619 | Serum marker for measuring liver fibrosis The invention provides methods and kits to detect liver fibrosis or a change in the gradation of liver fibrosis in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum. | 07/17/2007 |
| 7183261 | Galactosylceramide analogs, and β-glucocerebrosidase activators, external skin preparations and method of activating β-glucocerebrosidase using the analogs Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having ... | 02/27/2007 |
| 7160856 | α-O-linked glycoconjugates, methods of preparation and uses thereof The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tum... | 01/09/2007 |
| 7157443 | exopolysaccharide and process A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating... | 01/02/2007 |
| 7148260 | Water-based emulsifier wax gels including free sphingoid bases and oil in-water emulsion including the same Water-based emulsifier wax gels are provided that include skin-identical sphingolipids The present invention also provides a process for the preparation of such gels, the use of such gels for the preparation of oil-in-water emulsions, and the resulting emulsions tha... | 12/12/2006 |
| 7132412 | Treatment of skin diseases using a pharmaceutical preparation in colloidal form A new use of a suitable colloidal mixture of hyaluronic acids, of different molecular weights mixed together in a proper ratio in the treatment of the cutaneous diseases is described. ... | 11/07/2006 |
| 7125860 | Cross-linked derivatives of hyaluronic acid The present invention describes a new class of cross-linked derivatives of partially N-deacetylated hyaluronic acid or derivatives thereof, comprising at least one repeating unit of formula (I) hereinafter depicted and a process for the preparation of said cross-lin... | 10/24/2006 |
| 7125852 | Geranyl compounds This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significa... | 10/24/2006 |
| 7109323 | Formulation of boronic acid compounds The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provi... | 09/19/2006 |
| 7098195 | Fluorinated glucosamine analogs useful for modulating post-translational glycosylations on cells The present invention provides compositions and methods for inhibiting cell migration, e.g., lymphocytes and inflammation. The invention also provides an improved process for preparing fluorinated N-acetylglucosamines. ... | 08/29/2006 |
| 7094763 | Substituted fused heterocyclic C-glycosides This invention relates to substituted fused heterocyclic C-glycosides, compositions containing them, and methods of using them, for example, for the treatment or prophylaxis of diabetes and Syndrome X. ... | 08/22/2006 |
| 7091008 | Hyaluronan synthase genes and expression thereof in hosts The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cel... | 08/15/2006 |
| 7091337 | Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The... | 08/15/2006 |
| 7067640 | Cross-linked chiral compounds and methods of making thereof The invention relates to a method which comprises synthesizing bifunctional compounds then chiral compounds from the bifunctional compounds, also to synthesizing supports comprising these chiral compounds, and the use of these supports for preparing or separating en... | 06/27/2006 |
| 7060685 | Compounds and methods for inhibiting selectin-mediated function Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med... | 06/13/2006 |
| 7056900 | Disaccharide derivatives for treating hyperglycaemia The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias. ... | 06/06/2006 |
| 7056899 | Disaccharide derivatives for treating hyperglycaemia The invention relates to the use of the disaccharide derivatives 3′-aminosucrose, sucrose-C6-acid and palatinose-C6′-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias. ... | 06/06/2006 |
| 7041818 | DDS compound and method for measurement thereof A DDS compound comprising a carboxy(C1-4)alkyldextran polyalcohol modified with a saccharide compound and a residue of drug compound bound to the carboxy(C1-4)alkyldextran polyalcohol, and a method for measuring a DDS compound in which a polyme... | 05/09/2006 |
| 7041762 | Polyvalent imprinted polymer and process of preparation thereof The present invention relates to a polyvalent imprinted polymer useful in medicine and biotechnology and to a process for the preparation thereof. More particularly it relates to the said polymer of formula (1) herein below | 05/09/2006 |
