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| Number | Title | Issue Date |
| 8008476 | Room temperature stable agarose solutions The present invention provides methods for making porous crosslinked polysaccharide hydrogel coated structures. The methods include impregnating a porous substrate with a room temperature stable aqueous polysaccharide solution containing, water, a polysaccharide hav... | 08/30/2011 |
| 7807823 | Method of forming polysaccharide structures A process for forming polysaccharide structures such as beads, gel films and porous coatings on porous substrates by forming a room temperature gel-inhibited solution of a polysaccharide, one or more gel-inhibiting agent(s) and a solvent such as water, heating the m... | 10/05/2010 |
| 7265098 | Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen... | 09/04/2007 |
| 7101863 | Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative The invention concerns pharmaceutical compositions with wound healing or anti-complementary activity, and their uses, said compositions comprising, (1) at least a dextran derivative of general formula DMCaBbSuc, a, b, and c respectiv... | 09/05/2006 |
| 7070943 | Detection of protein conformations in single cells Methods, reagents, and kits are provided that permit flow cytometric determination of the phosphorylation status of retinoblastoma susceptibility gene protein (pRB) in individual cells. Methods are described that permit the hypophosphorylated, active, form of pRB to... | 07/04/2006 |
| 7053069 | Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives Pharmaceutical compositions containing C-21 modified epothilone derivatives, methods for their preparation and dosing regimen for administration of these epothilone compounds are provided. The compositions are stable and readily prepared for administration by dissol... | 05/30/2006 |
| 7041730 | Polymers and their synthesis The invention relates to polysaccharide graft polymers useful for incorporation as benefit agents in laundry detergent and fabric treatment compositions, and their preparation. The invention also relates to substituted polysaccharides useful as macroinitiator interm... | 05/09/2006 |
| 7005426 | Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and us... | 02/28/2006 |
| 7005513 | Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner from glycosaminoglycan controlling adhesion, migration and prolifera... | 02/28/2006 |
| 6949524 | Polysaccharide conjugates of biomolecules Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified polysaccha... | 09/27/2005 |
| 6869938 | Compositions of polyacids and polyethers and methods for their use in reducing adhesions The present invention relates to improved methods for making and using bioadhesive, bioresorbable, anti-adhesion compositions made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cation... | 03/22/2005 |
| 6838450 | Drug complex A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to ... | 01/04/2005 |
| 6730661 | Nutritional composition which contain non-digestible polysaccharides and use thereof to reduce transport through tight junctions The present invention relates to the use of one or more non-digestible polysaccharides selected from the group consisting of dextrans having a molecular weight of 8 kD to 40,000 kD, hydrolysed (gluco)mannans having a molecular weight of 0.5 kD to 1,000 kD and hydrol... | 05/04/2004 |
| 6656685 | Hybridization buffers using low molecular weight dextran sulfate and methods for their use The invention is directed to an improvement in automated tissue staining system having evaporation inhibitor liquid covering the polynucleotide hybridization buffer-covered tissue on a slide, wherein the improvement comprises a polynucleotide hybridizatio... | 12/02/2003 |
| 6646120 | Dextran derivatives, preparation and medicinal applications The invention concerns dextran derivatives, their applications as medicines with specific biological action, and their preparation method. Said derivatives correspond to the general formula DMCa Bb SUc Sd, in wh... | 11/11/2003 |
| 6528629 | Malto-oligosaccharide derived glycosides Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an alcohol or a thiol under conditions suitable to form a ... | 03/04/2003 |
| 6489309 | Polysaccharide conjugates of biomolecules Compounds that are modified polysaccharides having pendant aldehyde functionalities are disclosed. Each of the aldehyde functionalities is attached through a linker to a position corresponding to a hydrogen atom of a different hydroxyl group of unmodified... | 12/03/2002 |
| 6436912 | Drug complexes A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C1-4)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization ar... | 08/20/2002 |
| 6348629 | Free radical inhibitors for quenching aqueous phase polymer growth and related methods An aqueous phase inhibitor for quenching free radical polymerization comprising a free radical quenching agent having a hydrophilic tail is disclosed, as well as a coating and related methods. In one embodiment, the free radical quenching agent can either... | 02/19/2002 |
| 6319380 | Use of an earlier known separation material and novel forms of the material The use of a gel produced by polymerization of a dextran derivative which exhibits groups that contain an alkene structure, for separating nucleic acid by electrophoresis.... | 11/20/2001 |
| 6262256 | Article for tuesyl-activated dextran for solid-phase coupling A method of modifying the binding properties on a surface of a solid phase on which there are nucleophilic groups, which is characterized in that the surface is treated with a solution of an activated polysaccharide; a method of immobilizing a chemical co... | 07/17/2001 |
| 6127348 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 10/03/2000 |
| 6120987 | Non-aggregated fluorescent conjugates and the process for their preparation The invention relates to a process for the preparation of a fluorescent conjugate between a carrier molecule possessing at least one amino, hydroxyl, carboxyl and/or sulfhydryl group and a fluorophoric reagent possessing at least one functional group capa... | 09/19/2000 |
| 6121430 | Regiospecific synthesis of glucose-based surfactants New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active ... | 09/19/2000 |
| 6018035 | Reagents for isotropic size enhancement of a peptide, protein, nucleotide or other substrate Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally ... | 01/25/2000 |
| 5948904 | Process for the preparation of aromatic carbamoyl-substituted polysaccharide derivatives The invention relates to a process for the preparation of polysaccharide-N-arylcarbamates in suitable form as supports for chromatography, which process comprises adding to polysaccharide carbamates, which may be substituted in the aryl moiety, an N-... | 09/07/1999 |
| 5886169 | Iodinated polymers, processes for preparing them and their applications as contrast media Iodized polymers, comprising a skeleton consisting of a dextrane onto which are grafted groups of the formula (I). Application of the these compounds as contrast products.... | 03/23/1999 |
| 5874569 | Method of preparing tresyl-activated dextran, article having tresyl-activated dextran fixed covalently to its surface, and immobilization of chemical compounds thereto A method of preparing a tresyl-activated dextran is disclosed in which an aqueous solution of dissolved dextran is reacted with a tresylating agent in a hexamethylphosphoric triamide and/or N-methyl pyrrolidinone solvent, and the formed tresyl-activated d... | 02/23/1999 |
| 5874232 | Relating to assay reagents We have discovered that the stability of a dilute peroxidase-containing solution is greatly enhanced by the addition of a specific substrate for the peroxidase, in the absence of peroxide. We provide a peroxidase-containing reagent consisting of a buffere... | 02/23/1999 |
| 5840677 | Boronic acid or borinic acid derivatives as enzyme stabilizers The invention relates to a detergent composition comprising an enzyme and a boronic acid or borinic acid derivative which acts as a stabilizer for the enzyme in detergent compositions. Specific boronic acid inhibiters include benzofuran substituted boroni... | 11/24/1998 |
| 5773227 | Bifunctional chelating polysaccharides This invention describes bifunctional polysaccharides conjugated to both a chelating group suitable for the selective complexation of metal cations, and a targeting peptide specific for a cellular substructure. These bifunctional polysaccharides are prima... | 06/30/1998 |
| 5707877 | Biodegradable gelatin-aminodextran particle coatings of and processes for making same The invention relates generally to colloidal particle having a core material and a gelatin/aminodextran coating with pendent functional groups attached thereto. Biological substances or molecules, especially monoclonal antibodies, may be attached to said ... | 01/13/1998 |
| 5693625 | Method of regenerating cells and tissues using functionalized dextrans Compositions useful for regenerating cells and tissues comprise at least one functionalized dextran which has been substituted with carboxymethyl, benzylamide, or benzylamide sulfonate. These dextrans can be used alone or in combination with acid or basic... | 12/02/1997 |
| 5635610 | Production of saccharide carboxylic acids A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a c... | 06/03/1997 |
| 5635611 | Production of saccharide carboxylic acids A process for producing a saccharide carboxylic acid or a salt thereof characterized in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a c... | 06/03/1997 |
| 5543389 | Covalent polar lipid-peptide conjugates for use in salves This invention herein describes a method of facilitating the entry of drugs into cells at pharmokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This lipid/drug conjugate targeting invention embodies a... | 08/06/1996 |
| 5543390 | Covalent microparticle-drug conjugates for biological targeting This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and deliver... | 08/06/1996 |
| 5543391 | Covalent microparticle-drug conjugates for biological targeting This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and deliver... | 08/06/1996 |
| 5502082 | Low density materials having good compression strength and articles formed therefrom A crosslinked, highly porous body derived from a water-soluble, hydrogel polymer, wherein the porous body is characterized in that it has an open-celled 3-dimensional lattice structure, a density of less than about 1.0 g/cm3 a surface area of e... | 03/26/1996 |
| 5490978 | Block copolymers of polysaccharides and polyalkylene oxides Polysaccharides (e.g., dextran) of different molecular weights were substituted at the anomeric carbon with polyalkylene oxides of different molecular weights to give novel diblock copolymers. The copolymers inhibit bacterial aggregation. The copolymers a... | 02/13/1996 |
