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| Number | Title | Issue Date |
| 7687619 | Room temperature stable agarose solutions Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain gel-inhibiting additives into an aqueous polysaccharide solution, the gel po... | 03/30/2010 |
| 7265099 | Use of chemical chelators as reversal agents for drug-induced neuromuscular block The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) whe... | 09/04/2007 |
| 7259153 | Drug formulation and delivery using crystalline methylated cyclodextrins The present invention is directed to pharmaceutical compositions containing crystalline methylated cyclodextrins, which enhance the solubility of the pharmaceutically active agent or agents of the formulation. ... | 08/21/2007 |
| 7226913 | Pharmaceutical compositions having Aadenosine receptor agonist activity The present invention provides compositions for oral administration of compounds having A2A adenosine receptor agonist activity. These compositions are useful for treatment of inflammatory conditions. ... | 06/05/2007 |
| 7214665 | 2-propynyl adenosine analogs having Aagonist activity and compositions thereof The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here. ... | 05/08/2007 |
| 7172884 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 02/06/2007 |
| 7166302 | Complexing agents for compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 01/23/2007 |
| 7115586 | Non-inclusion cyclodextrin complexes The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with β-cyclode... | 10/03/2006 |
| 7105500 | Process for the antimicrobial treatment of fiber materials A process for the antimicrobial treatment of fiber materials, comprising applying to the fiber material an inclusion complex of a fiber-reactive cyclodextrin derivative with an antimicrobial agent selected from the group consisting of (a) halogeno-o-hydroxydiphenyl ... | 09/12/2006 |
| 7091335 | Derivatized reduced malto-oligosaccharides Disclosed are derivatized malto-oligosaccharides and methods for the preparation thereof. In accordance with the disclosed invention, a malto-oligosaccharide is hydrogenated to thereby obtain a hydrogenated malto-oligosaccharide, and the resulting hydrogenated malto... | 08/15/2006 |
| 7087709 | Polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitro... | 08/08/2006 |
| 7048769 | Fiber with improved complexation qualities and cation-exchange properties The present invention concerns a process for treating a fiber or a fiber-based material such as a yarn, a woven, knitted or nonwoven textile material, paper, or leather, to improve its adsorption properties, wherein the following successive operations are carried ou... | 05/23/2006 |
| 7018609 | Compositions containing inclusion complexes The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclu... | 03/28/2006 |
| 7005513 | Functionalized glycosaminoglycan polymer and medical instruments and drugs by using the same The present invention provides a functionalized polymer which can be used extensively in the field of medical drugs as well as medical devices and which is obtainable in an organic synthetic manner from glycosaminoglycan controlling adhesion, migration and prolifera... | 02/28/2006 |
| 7005426 | Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof, pharmaceutical compositions having said complex as active component and us... | 02/28/2006 |
| 7001893 | Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof The present invention relates to an inclusion complex of Rifampicin and cyclodextrin (CD) that can be used as an anti-tubercular drug. The present invention also relates to a process for synthesizing inclusion complexes of the anti-tubercular drug, Rifampicin, with ... | 02/21/2006 |
| 6998479 | Derivatives of cyclodextrins The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD—(X—Y—ONH2)n, wherein CD is mono- or polydeoxy α-, β-, or γ-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing th... | 02/14/2006 |
| 6982256 | Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine or one of the pharmacologically acceptable acid addition salts thereof. ... | 01/03/2006 |
| 6949527 | 6-Mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block Disclosed is a 6-mercapto-cyclodextrin derivative having a general formula (I, ) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6) alkylene, optionally substituted with 1-3 OH groups, or (CH2)o-phenylene-CH2)p... | 09/27/2005 |
| 6924136 | Cyclodextrin glucanotransferase and its method of manufacture CGTase enzymatically acts on starch, dextrin, amylopectin, and amylose to produce primarily γ-CD, with quantities of β- and α-CD produced being smaller than the quantity of γ-CD produced, has an optimum pH of 10.5-11.0, an optimum temperature of about 60° C., a... | 08/02/2005 |
| 6884885 | Production of cyclodextrin complexes The process entails increasing the concentration of cyclodextrin to 15% (w/w) and above to form complexes through a precipitation process in order to increase the yield of complexes, increase the amount of guest complexed, and decrease the particle size of the compl... | 04/26/2005 |
| 6878695 | Compositions comprising cyclodextrin derivatives A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. The compositions are suitable for capturing unwanted molecules from inanimate surfaces, including fabrics, including carpets, and house... | 04/12/2005 |
| 6875840 | Polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one —NOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitro... | 04/05/2005 |
| 6864246 | Anilide and cyclodextrin complexes, their preparation and their use as medicine in particular for treating dyslipidemiae The invention concerns more particularly dodecylthio-phenylacetanilide derivative complexes such as (S)-2′,3′,5′-trimethyl-4′-hydroxy-α-dodecylthio-phenylacetanilide or related derivatives thereof and cyclodextrins. ... | 03/08/2005 |
| 6858723 | Amphiphile cyclodextrins, preparation and use thereof for solubilizing organized systems and incorporating hydrophobic molecules The invention provides cyclodextrin derivatives that may be used to transport hydrophobic molecules for pharmaceutical or cosmetic applications, by forming organised systems in an aqueous medium, alone or with phospholipids. The cyclodextrin derivatives of the prese... | 02/22/2005 |
| 6835718 | Biocleavable micelle compositions for use as drug carriers This invention discloses compositions and methods for preparing biocleavable or biodegradable micelle compositions for carrying and releasing drugs and other active agents for therapeutic or other medical uses. Methods are also disclosed for preparing biocleavable c... | 12/28/2004 |
| 6818630 | Biologically active materials The present disclosure concerns biologically active materials, particularly materials that comprise a biodegradeable polymer linked to a biologically active agent. The disclosure further concerns materials known as polymer-drug conjugates that typically contain a th... | 11/16/2004 |
| 6699849 | Cyclodextrin complexes of benzodiazepines Methods for enhancing the complexation efficiency of a drug with cyclodextrin and for enhancing the availability of a drug following administration of a cyclodextrin-drug complex.... | 03/02/2004 |
| 6673891 | Polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one --SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized --S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by... | 01/06/2004 |
| 6590096 | Process for the production of polysaccharide beads The present invention relates to a method for producing porous polysaccharide beads, comprising: (a) mixing a water-based solution of a polysaccharide under stirring with an essentially water-immiscible first organic phase to form an emulsion which separa... | 07/08/2003 |
| 6528629 | Malto-oligosaccharide derived glycosides Disclosed is a method for preparing a malto-oligosaccharide derived glycoside. Generally, the method comprises providing a malto-oligosaccharide and glycosylating the malto-oligosaccharide with an alcohol or a thiol under conditions suitable to form a ... | 03/04/2003 |
| 6475803 | Cyclodextrin derivatives and measurement of water contamination degree using the same A cyclodextrin derivative is an X-hydroxynaphthalene-Y-amidated cyclodextrin formed by subjecting a starting cyclodextrin to an addition reaction with A-hydroxyl-B-carboxyl naphthalane and used for measuring the contamination degree of water.... | 11/05/2002 |
| 6403759 | Polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one --SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized-S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by p... | 06/11/2002 |
| 6355627 | Branched cyclodextrin clathrate compound of hinokitiols and composition containing the same The invention has an object of providing a hinokitiol which is not damaged in the antibacterial activity and improved in the water solubility, heat stability (anti-sublimation characteristics) and corrosion to metals and also providing a composition compr... | 03/12/2002 |
| 6316613 | Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated -, ଲ-, and γ-cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of sulfation and narrow... | 11/13/2001 |
| 6232434 | Polymers for delivering nitric oxide in vivo Disclosed are novel polymers derivatized with at least one --SNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized --S-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by... | 05/15/2001 |
| 6204256 | Acylated cyclodextrin derivatives A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of said cyclodextrin are acylated with acyl groups where at least one of said acyl groups comprise a free carboxylic group.... | 03/20/2001 |
| 6197951 | Starch graft copolymer blast media The invention discloses a starch graft poly(meth)acrylate blast media which is effective in paint removal. The media is superior to a physical blend of the components (i.e., starch and acrylic polymers) and to either a starch polymer or an acrylic polymer... | 03/06/2001 |
| 6127530 | Method for the reduction of oxygenated compounds of rhenium or technetium The present invention relates in general to a method for the reduction of oxygenated compounds of rhenium and technetium and in particular to the reduction of perrhenate or pertechnetate ions. More particularly, the invention relates to reactions for the reduc... | 10/03/2000 |
| 6113880 | Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.... | 09/05/2000 |
