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| Number | Title | Issue Date |
| 6930093 | Use of ribofuranose derivatives against inflammatory bowel diseases A method for the prophylaxis or treatment of an inflammatory bowel disease is provided, comprising administering to a patient having or at risk of developing an inflammatory bowel disease a therapeutically or preventatively effective amount of one or more ribofurano... | 08/16/2005 |
| 6815542 | Nucleoside compounds and uses thereof Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat a... | 11/09/2004 |
| 6573248 | Monocyclic L-nucleosides, analogs and uses thereof Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in... | 06/03/2003 |
| 6552183 | Moncyclic L-nucleosides analogs Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in... | 04/22/2003 |
| 6495677 | Nucleoside compounds Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used... | 12/17/2002 |
| 6153744 | Nucleoside derivatives with photolabile protective groups The invention relates to nucleo-side derivatives with photo-unstable protective groups of the general formula (I) ##STR1## in which R1 is H, NO2, CN, OCH3, halogen, alkyl or alkoxyalkyl with 1 to 4 C atoms, R2 | 11/28/2000 |
| 6030960 | Method of treating hepatitis virus infections A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an alkyl lipid or alkyl lipid derivative.... | 02/29/2000 |
| 5886167 | 2'-deoxy-2'-epi-2'-fluorocoformycin 2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-- and -ଲ-D-ribofuranosyl bromides. Further, according to this invention,... | 03/23/1999 |
| 5831072 | Process for the preparation of 2'-deoxy-2'-halocoformycins or steroisomers thereof An object of this invention is to provide a novel process for the synthesis of a 2'-deoxy-2'-halocoformycin having an inhibitory activity against adenosine deaminase in a practically high yield. Thus, there is provided a process comprising multi-stage rea... | 11/03/1998 |
| 5789387 | Methods and compositions for treating fungal infections in mammals Methods of treating fungal infections are disclosed. The methods comprise administering a chitin synthesis inhibitor to a mammal in a continuous fashion so that at least a minimum effective concentration is maintained in the mammal's plasma or in a target... | 08/04/1998 |
| 5777100 | AICA riboside analogs Analogs of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) are provided which are useful in increasing extracellular levels of adenosine.... | 07/07/1998 |
| 5773607 | Processes for preparing 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof 2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin are synthesized in this invention through a multi-stage process via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-- and -ଲ-D-ribofuranosyl bromides. Further, according to this invention,... | 06/30/1998 |
| 5750675 | 2'-"up" fluorinated 2'-deoxy-arabinofuranosylpurines The present invention provides a compound having the structure: ##STR1## wherein R1 is hydrogen, benzyl or a substituted benzyl group; X is hydrogen, a flouro, an amino or a substituted amino group; Y is hydrogen, a methoxy, a methylthio, a benzylth... | 05/12/1998 |
| 5736554 | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties Compounds of the Formula ##STR1## wherein: K is N or N.fwdarw.O; Q is CH2 or O; T is ##STR2## or R3 O--CH2 ; X is a straight or branched chain alkylene, cycloalkylene or cycloalkenylene group, each of which is op... | 04/07/1998 |
| 5714599 | Process for the preparation of ste specific 1'-spiro-nucleosides The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R8 and R9 are as defined in claim 1, and to novel i... | 02/03/1998 |
| 5681947 | Oligonucleotides having universal nucleoside spacers Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each Rn is H, OH, F... | 10/28/1997 |
| 5618793 | Nikkomycin analogs Compounds of the formula ##STR1## wherein R3, R4, J, K, Z, and Het are as set forth herein are described. The compounds of formula I are useful as agents in the treatment of fungal infections.... | 04/08/1997 |
| 5472947 | Application of 4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-olate to the treatment of multiple sclerosis A composition for the treatment or prevention of multiple sclerosis is disclosed. It comprises mizoribine (4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-olate) as the effective component. It is a safe drug, exhibiting a minimal degree of side-effect... | 12/05/1995 |
| 5462929 | Treatment of psoriasis by administration of 4-carbamoyl-1-ଲ-D-ribofuranosylimidszolium-5-oleate A composition for curing proliferative skin diseases containing 4-carbamoyl-1-ଲ-D-ribofuranosyl-imidazolium 5-olate (mizoribine) as an active ingredient. It has a potent activity of inhibiting the growth of keratinocytes and an improved effect of cu... | 10/31/1995 |
| 5455339 | Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides A method for preparing 2',3'-didehydrodideoxynucleosides and the corresponding reduced 2',3'-dideoxynucleosides which includes i) preparing a nucleoside derivative of the general structure ##STR1## wherein B is a nitrogen, oxygen, or sulfur heterocycle o... | 10/03/1995 |
| 5442051 | Anhydrous crystal of 4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-oleate Anhydrous crystals of 4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-olate are disclosed. The crystals possess (1) water content of 0.5% by weight or less (the Karl Fisher method), and (2) specific IR spectrum absorption peaks in the neighborhoods of... | 08/15/1995 |
| 5438131 | 3-nitropyrrole nucleoside Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each Rn is H, OH, F... | 08/01/1995 |
| 5243042 | 1-thiaguanosine and process for preparing oxanosine and 1-thiaguanosine The invention relates to antibacterially active 5-amino-3-(ଲ-D-ribofuranosyl)imidazo[4,5-d][1,3]thiazin-7(3H)-one, also referred to as 1-thiaguanosine, a composition and method comprising the same and processes and intermediates for the preparation ... | 09/07/1993 |
| 5238926 | Anti-fungal agents Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein R3, R4, R7, J, K, Z and Het are as set forth herein are described. The compounds of formula I are useful as agents in the treatment of ... | 08/24/1993 |
| 5149795 | Nikkomycin derivatives The nikkomycin compound possessing antimycotic activity and having the following structure: ##STR1##... | 09/22/1992 |
| 5093324 | Thiadiazole antiviral agents Ribosylated 2-amino-1,3,4-thiadiazoles having antiviral activity, methods of use and pharmaceutical formulations therefor.... | 03/03/1992 |
| 5082933 | Antitumor antibiotic BMY-42448 A new antibiotic designated BMY-42448 is produced by fermentation of Micromonospora narashinoensis strain C39217-R109-7 (ATCC-53791). BMY-42448 exhibits both in vitro and in vivo antitumor activity.... | 01/21/1992 |
| 5082829 | AICA riboside prodrugs Prodrugs of AICA riboside are provided which increase the bioavailability of AICA riboside and thereby increase extracellular concentrations of the prophylactic and affirmative treatment of various pathologic conditions, including ischemia. Also provided ... | 01/21/1992 |
| 5059590 | Imidazole derivatives, process for production thereof, and use thereof Disclosed are imidazole derivatives represented by formula [I]: ##STR1## wherein R is a hydrogen atom or ##STR2## wherein R2 is a hydrogen atom or a hydroxy protecting group, R2 protecting either a single hydroxy or two hyd... | 10/22/1991 |
| 4992426 | Antiparasitic 5'-sulfamoyl nucleosides The triazole nucleosides 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carboxamide, 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-thiocarboxamide and 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carbonitrile... | 02/12/1991 |
| 4952234 | Imidazoledione compounds useful as herbicides A new compound, named Substance No. 51262, may be produced by cultivating a suitable microorganism of the genus Streptomyces, especially the new strain SANK 63584 (FERM BP-958). Said compound has herbicidal and growth retardant properties. Said compound h... | 08/28/1990 |
| 4877776 | K-252 compounds A K-252 compound represented by the formula: ##STR1## wherein R1 and R2 are independently H or OH; X represents COOH, COOR or CH2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower... | 10/31/1989 |
| 4808613 | Rebeccamycin derivative containing pharmaceutical composition There are disclosed analogs of the antitumor agent, rebaccamycin, which possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin pro... | 02/28/1989 |
| 4575498 | Method for restoring depleted purine nucleotide pools A method of increasing the rate of repletion of purine nucleotide pools in tissue deficient in the nucleotides, which comprises administering to a human or animal a therapeutically effect amount of 5-amino-4-imidazolecarboxamide riboside, 5-amino-4-imidaz... | 03/11/1986 |
| 4552955 | Process for the synthesis of 4',5'-unsaturated nucleosides Process for the production of 4',5'-unsaturated nucleosides via a novel compound, 5'-Se-(2- or 4-nitrophenyl)-selenonucleoside, is disclosed, said selenonucleoside being represented by the formula ##STR1## wherein R is a hydrogen atom or a hydroxyl g... | 11/12/1985 |
| 4531001 | 2-ଲ-D-ribofuranosylselenazole-4-carboxamide compounds A class of novel 2-ଲ-D-ribofuranosylselenazole-4-carboxamide nucleoside and nucleotide compounds and methods for their production are provided. Compounds of the class typically have pharmacological properties, especially antitumor and antiviral prop... | 07/23/1985 |
| 4524145 | 4'-Deschlororebeccamycin pharmaceutical composition and method of use A new antitumor antibiotic designated herein as 4'-deschlororebeccamycin is produced by fermentation of Nocardia aerocolonigenes ATCC 39243. The new compound possesses antibacterial activity and inhibits the growth of tumors in experimental animals.... | 06/18/1985 |
| 4462992 | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof Compounds of the formula: ##STR1## wherein W is selected from the group consisting of ##STR2## Wherein Q is hydrogen or --CH2 OR1 ; Z is hydrogen or --OR1 ; n is 1 or 2; wherein R1 are the same or different... | 07/31/1984 |
| 4321366 | Process of preparing 2-azido-2-deoxyarabinofuranosyl halides Novel arabinofuranosyl nucleosides and nucleotides having 2'-azido,2'-amino, or 2'-hydrocarbylamino substituents, which have antitumor, antiviral, and antimicrobial properties, are prepared by condensation of a pyrimidine, purine, or 1,3-oxazine base with... | 03/23/1982 |
| 4293690 | Production of 2,6-diaminonebularines Compounds of the formula ##STR1## wherein R is phenyl which may be substituted; or their acid addition salts, are produced in good yield by reacting a compound of the formula ##STR2## wherein R1, R2 and R3, inde... | 10/06/1981 |
