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| Number | Title | Issue Date |
| 7365057 | Modified 2′ and 3′-nucleoside prodrugs for treating infections 2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and o... | 04/29/2008 |
| 7285660 | Process for the preparation of L-ribavirin ... | 10/23/2007 |
| 7285659 | Process for the preparation of D-ribavirin A process for the preparation of ribavirin on an industrial scale is described which comprises the reaction of glycosylation of 3-substituted triazoles in the presence of a Lewis acid. Said process comprises: a) the reaction of a t... | 10/23/2007 |
| 7268119 | Tricyclic nucleosides or nucleotides as therapeutic agents Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively. ... | 09/11/2007 |
| 7083961 | Crystal structures of inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof The invention provides a crystalline complex containing T. foetus IMPDH in complex with inosine monophosphate (IMP), the complex specified by disclosed atomic coordinates. Also provided are crystalline complexes of containing T. foetus IMPDH with both ... | 08/01/2006 |
| 7053207 | L-ribo-LNA analogues Provided are L-ribo bicyclic nucleotide compounds as well as syntheses of such compounds. The nucleoside compounds of the invention are useful in forming oligonucleotides that can produce nucleobase specific duplexes with complementary single stranded and double str... | 05/30/2006 |
| 7034161 | Process for producing a ribofuranose A method of converting pure α-anomer or β/α-anomer mixtures of 1,2,3,5-tetra-O-acetyl-L-ribofuranose to methyl-1-(2,3,5-tri-O-acetyl-β-L-ribofuranosyl)-1,2,4-triazole-3-carboxylate an intermediate for levovirin, as well as, the novel pure α-anomer, alpha 1,2,3,... | 04/25/2006 |
| 7022830 | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nucleic acids and pept... | 04/04/2006 |
| 6960569 | Hepatitis C virus non-structural NS3/4A fusion gene Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the inevntion include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed to said peptides, compositions containing said nuclei... | 11/01/2005 |
| 6930093 | Use of ribofuranose derivatives against inflammatory bowel diseases A method for the prophylaxis or treatment of an inflammatory bowel disease is provided, comprising administering to a patient having or at risk of developing an inflammatory bowel disease a therapeutically or preventatively effective amount of one or more ribofurano... | 08/16/2005 |
| 6924270 | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection Ribavirin derivatives represented by the formula II, pharmaceutical compositions containing them as well as methods of using the ribavirin derivatives represented by the formula II for the treatment of susceptible viral infections, for example, chronic hepatitis C i... | 08/02/2005 |
| 6900298 | Process for producing nucleic acid derivative A process for efficiently producing a nucleic acid derivative by condensing a specific nitrogen-containing heterocyclic compound such as a dinitrogen 6-membered heterocyclic compound or a trinitrogen 5-membered heterocyclic compound with a pentose using a less expen... | 05/31/2005 |
| 6858590 | Vaccines containing ribavirin and methods of use thereof Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising ribavirin and an antigen, preferably an antigen that has an epitope presen... | 02/22/2005 |
| 6846918 | Nucleoside modifications by palladium catalyzed methods This invention discloses a method for the preparation of 2′-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the metho... | 01/25/2005 |
| 6815542 | Nucleoside compounds and uses thereof Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat a... | 11/09/2004 |
| 6790837 | Ribavirin syrup formulations A liquid formulation comprising ribavirin having a longer shelf life and improved taste is disclosed. ... | 09/14/2004 |
| 6660721 | Anti-HCV nucleoside derivatives The present invention comprises nucleoside derivatives for use in the treatment or prophylaxis of hepatitis C virus infections. In particular, the present invention discloses the novel use of known 2'-deoxy-2'-fluoro nucleoside derivatives as inhibitors o... | 12/09/2003 |
| 6660854 | Processes for preparing ଲ-D-ribofuranose derivatives Provided are a process for preparing ଲ-D-ribofuranose derivatives, which are useful as an intermediate for the preparation of ribavirin. The process can be performed under a mild condition, in the presence of a catalyst selected from the group consi... | 12/09/2003 |
| 6642206 | Monocyclic L-nucleosides, analogs and uses thereof Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in... | 11/04/2003 |
| 6573248 | Monocyclic L-nucleosides, analogs and uses thereof Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in... | 06/03/2003 |
| 6552183 | Moncyclic L-nucleosides analogs Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. Viewed in... | 04/22/2003 |
| 6525191 | Conformationally constrained L-nucleosides L-nucleosides are conformationally constrained by at least one additional ring formed by a bridge connecting at least two atoms within a sugar moiety of the nucleoside. While a single additional ring is formed by bridging C1 -C4 atom... | 02/25/2003 |
| 6518253 | Treatment of viral infections using the L-isomer of ribavirin A 1-(ଲ-L-ribofuranosyl)-1,2,4-triazole-3-carboxamide is administered in a method of treatment of a viral infection in a patient, including HIV infection, HCV infection, or BHV infection.... | 02/11/2003 |
| 6495677 | Nucleoside compounds Nucleosides, novel nucleoside analog compounds and their novel prodrug forms are disclosed. The novel compounds, prodrugs, or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used... | 12/17/2002 |
| 6150337 | Specific modulation of Th1/Th2 cytokine expression by Ribavirin in activated T-lymphocytes Ribavirin is employed in a manner which is effective to modulate lymphokine expression in activated T cells. In particular, Ribavirin is used to suppress Type 2-mediated T cell responses and promote Type 1-mediated T cell response. Thus, instead of admini... | 11/21/2000 |
| 6130326 | Monocyclic L-Nucleosides, analogs and uses thereof Novel monocyclic L-Nucleoside compounds have the general formula ##STR1## Embodiments of these compounds are contemplated to be useful in treating a wide variety of diseases including infections, infestations, neoplasms, and autoimmune diseases. View... | 10/10/2000 |
| 6063772 | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes Ribavirin is administered to a patient in a dosage range which is effective to modulate lymphokine expression In activated T cells. In particular, ribavirin is used to suppress Th2-mediated T cell responses and promote Th1-mediated T cell response. Thus, ... | 05/16/2000 |
| 6030960 | Method of treating hepatitis virus infections A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an alkyl lipid or alkyl lipid derivative.... | 02/29/2000 |
| 5968910 | Compositions containing two or three inhibitors of different HIV reverse transcriptases A composition and method for the prevention or treatment of HIV-1 infection comprising an HIV-1 reverse transcriptase-inhibiting heterocyclyl carb(ox/thio)anilide compound, a second HIV-1 reverse transcriptase inhibitor compound which does not select for ... | 10/19/1999 |
| 5777100 | AICA riboside analogs Analogs of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide (AICA riboside) are provided which are useful in increasing extracellular levels of adenosine.... | 07/07/1998 |
| 5767097 | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes Ribavirin is administered to a patient in a dosage range which is effective to modulate lymphokine expression in activated T cells. In particular, ribavirin is used to suppress Th2-mediated T cell responses and promote Th1-mediated T cell response. Thus, ... | 06/16/1998 |
| 5714599 | Process for the preparation of ste specific 1'-spiro-nucleosides The invention relates to a novel process for stereocontrolled preparation of 1',1'-disubstituted and 1'-spiro-nucleosides of the formula I ##STR1## in which the substituents A, R8 and R9 are as defined in claim 1, and to novel i... | 02/03/1998 |
| 5681947 | Oligonucleotides having universal nucleoside spacers Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each Rn is H, OH, F... | 10/28/1997 |
| 5618793 | Nikkomycin analogs Compounds of the formula ##STR1## wherein R3, R4, J, K, Z, and Het are as set forth herein are described. The compounds of formula I are useful as agents in the treatment of fungal infections.... | 04/08/1997 |
| 5442051 | Anhydrous crystal of 4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-oleate Anhydrous crystals of 4-carbamoyl-1-ଲ-D-ribofuranosyl imidazolium-5-olate are disclosed. The crystals possess (1) water content of 0.5% by weight or less (the Karl Fisher method), and (2) specific IR spectrum absorption peaks in the neighborhoods of... | 08/15/1995 |
| 5438131 | 3-nitropyrrole nucleoside Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each Rn is H, OH, F... | 08/01/1995 |
| 5238926 | Anti-fungal agents Compounds of the formula ##STR1## or pharmaceutically acceptable salts thereof wherein R3, R4, R7, J, K, Z and Het are as set forth herein are described. The compounds of formula I are useful as agents in the treatment of ... | 08/24/1993 |
| 4992426 | Antiparasitic 5'-sulfamoyl nucleosides The triazole nucleosides 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carboxamide, 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-thiocarboxamide and 1-(5'-O-sulfamoyl-ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carbonitrile... | 02/12/1991 |
| 4925930 | Synthesis and anti-leukemic activity of alkyl-1-(ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates A novel class of alkyl-1-(ଲ-D-ribofuranosyl)[1,2,4]triazole-3-carboximidates of the formula: ##STR1## wherein R1 is methyl or ethyl and R2 is ଲ-D-ribofuranosyl, are useful as anti-leukemic agents.... | 05/15/1990 |
| 4704454 | Pyranoderivatives, their preparation and therapeutic compositions containing the same This invention relates to new pyranoderivatives of the formula: ##STR1## wherein X1 is H, Cl or Br and Z stands for: ##STR2## wherein X2 is H, Cl or Br, T is O or S and Y stands for an arabinose, xylose or ribose moiety, th... | 11/03/1987 |
